SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fbt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 1fbt FRUCTOSE-2,6-BISPHOS
PHATASE
(Rattus
norvegicus) 		3 / 3 GLU A  84
ILE A  19
ARG A   7
 None
None
PO4  A 300 (-3.9A)
 0.82A 1cd2A-1fbtA:
undetectable		 1cd2A-1fbtA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_A_SAMA417_0
(L-LYSINE
2,3-AMINOMUTASE)		 1fbt FRUCTOSE-2,6-BISPHOS
PHATASE
(Rattus
norvegicus) 		5 / 11 THR A  61
GLN A  71
VAL A  50
TYR A  69
LEU A  36
 None
 1.45A 2a5hA-1fbtA:
0.0		 2a5hA-1fbtA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_C_SAMC417_0
(L-LYSINE
2,3-AMINOMUTASE)		 1fbt FRUCTOSE-2,6-BISPHOS
PHATASE
(Rattus
norvegicus) 		5 / 12 THR A  61
GLN A  71
VAL A  50
TYR A  69
LEU A  36
 None
 1.46A 2a5hC-1fbtA:
0.0		 2a5hC-1fbtA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)		 1fbt FRUCTOSE-2,6-BISPHOS
PHATASE
(Rattus
norvegicus) 		5 / 12 THR A  61
GLN A  71
VAL A  50
TYR A  69
LEU A  36
 None
 1.44A 2a5hD-1fbtA:
undetectable		 2a5hD-1fbtA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1fbt FRUCTOSE-2,6-BISPHOS
PHATASE
(Rattus
norvegicus) 		4 / 6 GLU A 115
ILE A  78
GLU A  77
ASN A  76
 None
None
PO4  A 300 (-3.4A)
None
 0.96A 3pgyA-1fbtA:
undetectable
3pgyB-1fbtA:
undetectable		 3pgyA-1fbtA:
18.07
3pgyB-1fbtA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_B_GCSB304_1
(CHITOSANASE)		 1fbt FRUCTOSE-2,6-BISPHOS
PHATASE
(Rattus
norvegicus) 		4 / 5 TYR A  32
ILE A 140
THR A  61
HIS A 142
 None
None
None
PO4  A 300 (-3.8A)
 1.22A 4oltB-1fbtA:
0.0		 4oltB-1fbtA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC404_0
(PROTON-GATED ION
CHANNEL)		 1fbt FRUCTOSE-2,6-BISPHOS
PHATASE
(Rattus
norvegicus) 		4 / 4 ILE A 128
ILE A   3
ARG A   1
TYR A 152
 None
 1.34A 4zzbC-1fbtA:
undetectable		 4zzbC-1fbtA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_C_ACTC407_0
(PROTON-GATED ION
CHANNEL)		 1fbt FRUCTOSE-2,6-BISPHOS
PHATASE
(Rattus
norvegicus) 		4 / 4 ILE A 128
ILE A   3
ARG A   1
TYR A 152
 None
 1.49A 4zzcC-1fbtA:
undetectable		 4zzcC-1fbtA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_D_ACTD406_0
(PROTON-GATED ION
CHANNEL)		 1fbt FRUCTOSE-2,6-BISPHOS
PHATASE
(Rattus
norvegicus) 		4 / 4 ILE A 128
ILE A   3
ARG A   1
TYR A 152
 None
 1.48A 4zzcD-1fbtA:
undetectable		 4zzcD-1fbtA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1fbt FRUCTOSE-2,6-BISPHOS
PHATASE
(Rattus
norvegicus) 		5 / 6 LEU A  48
VAL A  67
LEU A 138
LEU A  75
GLU A 130
 None
 1.34A 5tudD-1fbtA:
undetectable		 5tudD-1fbtA:
17.49