SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fbv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 1fbv SIGNAL TRANSDUCTION
PROTEIN CBL
(Homo
sapiens) 		4 / 5 TYR A  83
PRO A  89
THR A 152
ARG A 148
 None
 1.15A 1i2wA-1fbvA:
undetectable		 1i2wA-1fbvA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 1fbv SIGNAL TRANSDUCTION
PROTEIN CBL
(Homo
sapiens) 		4 / 5 TYR A  83
PRO A  89
THR A 273
THR A 152
 None
 1.12A 1ymxB-1fbvA:
undetectable		 1ymxB-1fbvA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 1fbv SIGNAL TRANSDUCTION
PROTEIN CBL
(Homo
sapiens) 		5 / 12 LEU A  88
LEU A 151
THR A 152
LEU A 154
PHE A 158
 None
 0.74A 2bdmA-1fbvA:
0.0		 2bdmA-1fbvA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 1fbv SIGNAL TRANSDUCTION
PROTEIN CBL
(Homo
sapiens) 		5 / 12 LEU A  88
THR A 152
LEU A 154
SER A 155
PHE A 158
 None
 0.71A 2bdmA-1fbvA:
0.0		 2bdmA-1fbvA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)		 1fbv SIGNAL TRANSDUCTION
PROTEIN CBL
(Homo
sapiens) 		3 / 3 ASP A 390
THR A  50
GLU A 120
 None
 0.77A 2zifB-1fbvA:
undetectable		 2zifB-1fbvA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 1fbv SIGNAL TRANSDUCTION
PROTEIN CBL
(Homo
sapiens) 		3 / 3 LYS A 322
PRO A 323
LEU A 324
 None
 0.87A 3tpxE-1fbvA:
0.0		 3tpxE-1fbvA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_1
(WBDD)		 1fbv SIGNAL TRANSDUCTION
PROTEIN CBL
(Homo
sapiens) 		4 / 6 GLN A 316
ASP A 275
GLU A 143
LEU A 281
 None
 1.29A 4ax8A-1fbvA:
0.0		 4ax8A-1fbvA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EVR_A_BEZA401_0
(PUTATIVE ABC
TRANSPORTER SUBUNIT,
SUBSTRATE-BINDING
COMPONENT)		 1fbv SIGNAL TRANSDUCTION
PROTEIN CBL
(Homo
sapiens) 		5 / 11 LEU A 230
TYR A 268
ALA A 262
PHE A 248
PHE A 244
 None
 1.08A 4evrA-1fbvA:
0.0		 4evrA-1fbvA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1fbv SIGNAL TRANSDUCTION
PROTEIN CBL
(Homo
sapiens) 		4 / 7 GLU A 369
GLU A 366
TYR A 368
GLY A 218
 None
 1.03A 4fgzA-1fbvA:
undetectable		 4fgzA-1fbvA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LA0_A_198A601_1
(SERUM ALBUMIN)		 1fbv SIGNAL TRANSDUCTION
PROTEIN CBL
(Homo
sapiens) 		5 / 10 ARG A 148
PRO A 147
GLU A 138
PHE A 133
LEU A  75
 None
 1.49A 4la0A-1fbvA:
2.6		 4la0A-1fbvA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESH_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1fbv SIGNAL TRANSDUCTION
PROTEIN CBL
(Homo
sapiens) 		5 / 12 LEU A  88
PHE A 115
GLY A 110
THR A  50
MET A 119
 None
 1.04A 5eshA-1fbvA:
0.1		 5eshA-1fbvA:
19.57