SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fc4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 8 PHE A 318
MET A 313
PHE A 309
LEU A 345
 None
 0.99A 1ea1A-1fc4A:
undetectable		 1ea1A-1fc4A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 8 HIS A 136
SER A 185
HIS A 213
LYS A 244
ARG A 368
 PLP  A1201 ( 3.4A)
AKB  A1200 ( 2.9A)
PLP  A1201 ( 3.9A)
PLP  A1201 ( 2.9A)
AKB  A1200 (-2.6A)
 0.94A 1eqbA-1fc4A:
29.3
1eqbB-1fc4A:
29.1		 1eqbA-1fc4A:
26.22
1eqbB-1fc4A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 8 HIS A 136
SER A 185
HIS A 213
LYS A 244
ARG A 368
 PLP  A1201 ( 3.4A)
AKB  A1200 ( 2.9A)
PLP  A1201 ( 3.9A)
PLP  A1201 ( 2.9A)
AKB  A1200 (-2.6A)
 0.94A 1eqbA-1fc4A:
29.3
1eqbB-1fc4A:
29.1		 1eqbA-1fc4A:
26.22
1eqbB-1fc4A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 8 HIS A 136
SER A 185
HIS A 213
LYS A 244
ARG A 368
 PLP  A1201 ( 3.4A)
AKB  A1200 ( 2.9A)
PLP  A1201 ( 3.9A)
PLP  A1201 ( 2.9A)
AKB  A1200 (-2.6A)
 0.93A 1eqbC-1fc4A:
29.2
1eqbD-1fc4A:
28.9		 1eqbC-1fc4A:
26.22
1eqbD-1fc4A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 8 HIS A 136
SER A 185
HIS A 213
LYS A 244
ARG A 368
 PLP  A1201 ( 3.4A)
AKB  A1200 ( 2.9A)
PLP  A1201 ( 3.9A)
PLP  A1201 ( 2.9A)
AKB  A1200 (-2.6A)
 0.93A 1eqbC-1fc4A:
29.2
1eqbD-1fc4A:
28.9		 1eqbC-1fc4A:
26.22
1eqbD-1fc4A:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.99A 1fbyA-1fc4A:
undetectable		 1fbyA-1fc4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.99A 1fbyB-1fc4A:
undetectable		 1fbyB-1fc4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.91A 1fm6A-1fc4A:
undetectable		 1fm6A-1fc4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.96A 1fm9A-1fc4A:
undetectable		 1fm9A-1fc4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 PHE A 309
GLY A 188
LEU A  53
ALA A 214
LEU A 302
 None
 0.98A 1jipA-1fc4A:
0.0		 1jipA-1fc4A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.88A 1k74A-1fc4A:
undetectable		 1k74A-1fc4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.96A 1xdkE-1fc4A:
undetectable		 1xdkE-1fc4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.88A 1xiuA-1fc4A:
undetectable		 1xiuA-1fc4A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.95A 1xlsA-1fc4A:
undetectable		 1xlsA-1fc4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.95A 1xlsB-1fc4A:
undetectable		 1xlsB-1fc4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.95A 1xlsC-1fc4A:
undetectable		 1xlsC-1fc4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.95A 1xlsD-1fc4A:
undetectable		 1xlsD-1fc4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_G_REAG501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.90A 2aclG-1fc4A:
undetectable		 2aclG-1fc4A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 8 LYS A 362
TYR A 357
LEU A  21
ALA A  16
 None
 0.98A 2bnnA-1fc4A:
undetectable
2bnnB-1fc4A:
undetectable		 2bnnA-1fc4A:
20.15
2bnnB-1fc4A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2002_1
(SERUM ALBUMIN)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 11 ARG A 382
ALA A 383
ALA A 386
LEU A 345
VAL A 352
 None
 0.83A 2bxeB-1fc4A:
undetectable		 2bxeB-1fc4A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_B_IBPB2002_1
(SERUM ALBUMIN)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 10 ARG A 382
ALA A 383
ALA A 386
LEU A 345
VAL A 352
 None
 0.74A 2bxgB-1fc4A:
undetectable		 2bxgB-1fc4A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXK_A_IMNA2001_1
(SERUM ALBUMIN)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 8 SER A 138
PHE A 119
LEU A 177
ASP A 211
 PLP  A1201 ( 4.0A)
None
None
None
 1.17A 2bxkA-1fc4A:
0.4		 2bxkA-1fc4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_B_SAMB1500_0
(ASPARTOKINASE)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 7 SER A 109
ASP A 113
ARG A 265
GLU A  93
 None
 1.09A 2cdqB-1fc4A:
1.3		 2cdqB-1fc4A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		3 / 3 HIS A  89
ILE A 286
LEU A  96
 None
 0.61A 2kceA-1fc4A:
0.0		 2kceA-1fc4A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 11 LEU A 100
LEU A  96
LEU A  92
ARG A 223
VAL A 292
 None
 1.03A 2qd3A-1fc4A:
3.5		 2qd3A-1fc4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 7 ALA A 214
GLY A 182
ASP A 211
VAL A 209
 None
 0.86A 2uyqA-1fc4A:
2.1		 2uyqA-1fc4A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 7 HIS A 136
HIS A 213
LYS A 244
ARG A 368
 PLP  A1201 ( 3.4A)
PLP  A1201 ( 3.9A)
PLP  A1201 ( 2.9A)
AKB  A1200 (-2.6A)
 0.61A 2vmyA-1fc4A:
29.6
2vmyB-1fc4A:
29.4		 2vmyA-1fc4A:
26.01
2vmyB-1fc4A:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 8 HIS A 136
SER A 185
HIS A 213
LYS A 244
ARG A 368
 PLP  A1201 ( 3.4A)
AKB  A1200 ( 2.9A)
PLP  A1201 ( 3.9A)
PLP  A1201 ( 2.9A)
AKB  A1200 (-2.6A)
 0.97A 2vmyA-1fc4A:
29.6
2vmyB-1fc4A:
29.5		 2vmyA-1fc4A:
26.01
2vmyB-1fc4A:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_A_ACTA1397_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		3 / 3 PRO A 270
GLY A 117
TYR A 108
 None
 0.71A 2vouA-1fc4A:
0.0		 2vouA-1fc4A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		3 / 3 PRO A 270
GLY A 117
TYR A 108
 None
 0.63A 2vouB-1fc4A:
0.0		 2vouB-1fc4A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		3 / 3 PRO A 270
GLY A 117
TYR A 108
 None
 0.62A 2vouC-1fc4A:
0.0		 2vouC-1fc4A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YK1_H_NCTH300_1
(FAB FRAGMENT, HEAVY
CHAIN
FAB FRAGMENT, LIGHT
CHAIN)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 10 GLY A 224
SER A 225
VAL A 215
TYR A 253
ALA A 255
 None
 1.45A 2yk1H-1fc4A:
0.0
2yk1L-1fc4A:
0.0		 2yk1H-1fc4A:
21.09
2yk1L-1fc4A:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 5 GLN A 370
PHE A  47
LEU A 345
PHE A 341
 None
 1.43A 3ablC-1fc4A:
undetectable
3ablJ-1fc4A:
0.0		 3ablC-1fc4A:
20.10
3ablJ-1fc4A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CO4_A_GCSA401_1
(CHITINASE)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		3 / 3 GLU A  91
HIS A  89
HIS A  72
 None
 0.93A 3co4A-1fc4A:
2.1		 3co4A-1fc4A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		3 / 3 TYR A 253
ASP A 210
HIS A 226
 None
PLP  A1201 (-2.7A)
None
 0.88A 3e23A-1fc4A:
undetectable		 3e23A-1fc4A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 10 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.89A 3falC-1fc4A:
undetectable		 3falC-1fc4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 11 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.92A 3fc6A-1fc4A:
undetectable		 3fc6A-1fc4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.91A 3oapA-1fc4A:
undetectable		 3oapA-1fc4A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 6 SER A 268
ILE A 106
TYR A 108
ASP A 210
 None
None
None
PLP  A1201 (-2.7A)
 0.85A 3q70A-1fc4A:
undetectable		 3q70A-1fc4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 8 PHE A  81
GLU A 262
TYR A 271
LEU A 272
 None
 1.12A 3rqwC-1fc4A:
undetectable
3rqwD-1fc4A:
undetectable		 3rqwC-1fc4A:
22.97
3rqwD-1fc4A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 8 GLU A 262
TYR A 271
LEU A 272
PHE A  81
 None
 1.10A 3rqwF-1fc4A:
0.0
3rqwJ-1fc4A:
0.0		 3rqwF-1fc4A:
22.97
3rqwJ-1fc4A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.93A 4nqaH-1fc4A:
0.0		 4nqaH-1fc4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB602_1
(SERUM ALBUMIN)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 9 ARG A 382
ALA A 383
ALA A 386
LEU A 345
VAL A 352
 None
 0.99A 4or0B-1fc4A:
undetectable		 4or0B-1fc4A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 8 LEU A 394
ILE A 367
ALA A 338
LEU A 332
 None
 0.84A 4qrcA-1fc4A:
undetectable		 4qrcA-1fc4A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_B_SAMB301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 5 TYR A  52
GLN A 370
SER A 185
ASP A 113
 None
None
AKB  A1200 ( 2.9A)
None
 1.17A 4qtuB-1fc4A:
2.6		 4qtuB-1fc4A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		3 / 3 ASP A 334
LEU A  21
GLY A  20
 None
 0.52A 4xmfA-1fc4A:
0.0		 4xmfA-1fc4A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2D_F_LFXF102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		3 / 4 ARG A 223
GLY A 224
GLU A 227
 None
 0.45A 4z2dB-1fc4A:
0.1
4z2dC-1fc4A:
undetectable		 4z2dB-1fc4A:
23.38
4z2dC-1fc4A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 5 GLY A 216
ARG A 223
GLY A 224
GLU A 227
 None
 0.83A 4z2eB-1fc4A:
0.0
4z2eC-1fc4A:
1.8		 4z2eB-1fc4A:
23.38
4z2eC-1fc4A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 LEU A  61
GLY A 248
TYR A  52
PHE A  99
LEU A 289
 None
 1.48A 5kklB-1fc4A:
undetectable		 5kklB-1fc4A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 6 LEU A 107
ILE A 237
THR A 254
MET A 208
 None
 1.43A 5ljeA-1fc4A:
0.0		 5ljeA-1fc4A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 6 ILE A 367
ALA A 342
LEU A 345
ILE A 390
 None
 0.69A 5mvmB-1fc4A:
0.0
5mvmC-1fc4A:
0.0		 5mvmB-1fc4A:
11.50
5mvmC-1fc4A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 10 VAL A 352
THR A 369
ILE A 367
LEU A 332
ALA A 383
 None
 0.92A 5mxbA-1fc4A:
0.5		 5mxbA-1fc4A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.90A 5uanA-1fc4A:
undetectable		 5uanA-1fc4A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 7 VAL A 183
VAL A 209
GLY A 224
TYR A 228
 None
 0.99A 5x80C-1fc4A:
0.0
5x80D-1fc4A:
0.0		 5x80C-1fc4A:
18.25
5x80D-1fc4A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.91A 5z12B-1fc4A:
undetectable		 5z12B-1fc4A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.88A 5z12C-1fc4A:
undetectable		 5z12C-1fc4A:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.93A 6a5yD-1fc4A:
undetectable		 6a5yD-1fc4A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 ILE A 238
ALA A 255
ALA A 256
LEU A 100
ALA A  97
 None
 0.92A 6a5zL-1fc4A:
undetectable		 6a5zL-1fc4A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		5 / 12 VAL A 235
LEU A 289
VAL A 292
THR A 241
GLY A 240
 None
None
None
PLP  A1201 (-3.4A)
None
 1.32A 6brdA-1fc4A:
undetectable		 6brdA-1fc4A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 1fc4 2-AMINO-3-KETOBUTYRA
TE CONENZYME A
LIGASE
(Escherichia
coli) 		4 / 7 VAL A 288
LEU A 277
GLY A 216
GLY A 251
 None
 0.75A 6eu9D-1fc4A:
0.0		 6eu9D-1fc4A:
13.05