SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fcd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 8 GLN A 311
VAL A 101
GLY A  13
GLY A  14
 None
None
FAD  A 699 (-3.4A)
None
 0.86A 1ekjE-1fcdA:
0.8
1ekjF-1fcdA:
0.7		 1ekjE-1fcdA:
20.81
1ekjF-1fcdA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)
(Allochromatium
vinosum;
Allochromatium
vinosum) 		4 / 7 GLY C  55
ALA A 350
ILE C  57
SER A 348
 None
None
HEM  C 901 ( 4.2A)
None
 0.76A 1gtnA-1fcdC:
undetectable
1gtnK-1fcdC:
undetectable		 1gtnA-1fcdC:
18.93
1gtnK-1fcdC:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)
(Allochromatium
vinosum;
Allochromatium
vinosum) 		4 / 8 GLY C  55
ALA A 350
ILE C  57
SER A 348
 None
None
HEM  C 901 ( 4.2A)
None
 0.82A 1gtnP-1fcdC:
undetectable
1gtnQ-1fcdC:
undetectable		 1gtnP-1fcdC:
18.93
1gtnQ-1fcdC:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)
FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 4 GLY C  13
ASP A 398
GLY A  13
THR A  41
 None
None
FAD  A 699 (-3.4A)
None
 1.02A 1hxbB-1fcdC:
undetectable		 1hxbB-1fcdC:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)
(Allochromatium
vinosum;
Allochromatium
vinosum) 		6 / 12 THR A  16
GLY A  14
GLY A  10
VAL A 101
TYR A  20
ASN C   9
 None
 1.47A 1n2xB-1fcdA:
undetectable		 1n2xB-1fcdA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 12 ILE A 187
ALA A 156
GLY A 222
SER A 225
TYR A 166
 None
 1.08A 1rjdA-1fcdA:
undetectable		 1rjdA-1fcdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 12 ILE A 187
ALA A 156
GLY A 222
SER A 225
TYR A 166
 None
 1.05A 1rjdB-1fcdA:
undetectable		 1rjdB-1fcdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 12 ILE A 187
ALA A 156
GLY A 222
SER A 225
TYR A 166
 None
 1.08A 1rjdC-1fcdA:
3.3		 1rjdC-1fcdA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1301_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)
(Allochromatium
vinosum) 		4 / 6 LEU C 166
PHE C 167
ALA C 168
LEU C  96
 HEM  C 902 (-4.6A)
None
None
None
 1.01A 1ukbA-1fcdC:
undetectable		 1ukbA-1fcdC:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_B_ACTB294_0
(GLYCINE
N-METHYLTRANSFERASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 6 TRP A 204
TYR A 208
ILE A 217
LEU A 341
 None
 0.95A 1xvaA-1fcdA:
3.4
1xvaB-1fcdA:
3.5		 1xvaA-1fcdA:
22.76
1xvaB-1fcdA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_B_CFXB1002_2
(BETA-LACTAMASE
CTX-M-9)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 5 TYR A  39
PRO A  35
THR A 399
THR A  16
 FAD  A 699 (-4.8A)
FAD  A 699 (-4.2A)
None
None
 1.46A 1ymxB-1fcdA:
undetectable		 1ymxB-1fcdA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 8 GLY A   9
THR A  16
ALA A  17
ALA A  18
 FAD  A 699 (-3.5A)
None
None
None
 0.46A 2ej3A-1fcdA:
undetectable		 2ej3A-1fcdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 8 GLY A   9
THR A  16
ALA A  17
ALA A  18
 FAD  A 699 (-3.5A)
None
None
None
 0.48A 2ej3C-1fcdA:
undetectable		 2ej3C-1fcdA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_A_DVAA35_0
(UBIQUITIN)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 4 GLN A 256
GLU A 107
ILE A 109
PRO A 255
 None
 1.35A 2fcnA-1fcdA:
undetectable		 2fcnA-1fcdA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 6 GLN A 256
GLU A 107
ILE A 109
PRO A 255
 None
 1.03A 2fcnA-1fcdA:
0.0
2fcnB-1fcdA:
0.0		 2fcnA-1fcdA:
11.47
2fcnB-1fcdA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		3 / 3 ALA A 315
GLY A  13
SER A 296
 None
FAD  A 699 (-3.4A)
None
 0.59A 2ivuA-1fcdA:
undetectable		 2ivuA-1fcdA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 5 ALA A 169
TRP A 204
LEU A 207
ALA A 173
 None
 1.27A 2jstA-1fcdA:
0.0
2jstB-1fcdA:
0.0		 2jstA-1fcdA:
9.48
2jstB-1fcdA:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		3 / 3 ARG A 160
VAL A  48
THR A 134
 FAD  A 699 (-3.1A)
None
None
 0.86A 2nnkA-1fcdA:
0.0		 2nnkA-1fcdA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 12 GLY A  11
PRO A 104
GLY A 105
ALA A  15
LEU A  65
 FAD  A 699 (-3.5A)
FAD  A 699 (-4.5A)
FAD  A 699 (-3.6A)
None
None
 0.70A 2plwA-1fcdA:
2.5		 2plwA-1fcdA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_H_CPFH1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		3 / 3 ARG A 257
GLU A 107
SER A 283
 None
 0.87A 2xctD-1fcdA:
0.1		 2xctD-1fcdA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM9_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 9 ALA A  77
ILE A  80
GLY A  79
ILE A 264
HIS A 286
 FAD  A 699 (-3.2A)
None
None
None
None
 1.45A 2zm9A-1fcdA:
0.0		 2zm9A-1fcdA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)
(Allochromatium
vinosum;
Allochromatium
vinosum) 		3 / 3 TYR A 306
ASP A 398
HIS C  15
 None
None
HEM  C 901 (-3.3A)
 0.90A 3e23A-1fcdA:
undetectable		 3e23A-1fcdA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 9 ASP A  75
VAL A   8
ILE A 261
GLY A  79
ILE A  33
 None
FAD  A 699 (-4.3A)
FAD  A 699 (-3.7A)
None
FAD  A 699 (-4.7A)
 1.00A 3ekqB-1fcdA:
undetectable		 3ekqB-1fcdA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 12 VAL A   8
ALA A  17
ALA A  18
ALA A 316
VAL A  87
 FAD  A 699 (-4.3A)
None
None
None
None
 0.84A 3fc6C-1fcdA:
undetectable		 3fc6C-1fcdA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 12 VAL A   8
GLY A   9
GLY A  11
ALA A  77
ILE A 261
 FAD  A 699 (-4.3A)
FAD  A 699 (-3.5A)
FAD  A 699 (-3.5A)
FAD  A 699 (-3.2A)
FAD  A 699 (-3.7A)
 0.95A 3fuuA-1fcdA:
3.0		 3fuuA-1fcdA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)
FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 4 GLY C  13
ASP A 398
GLY A  13
THR A  41
 None
None
FAD  A 699 (-3.4A)
None
 1.04A 3k4vC-1fcdC:
undetectable		 3k4vC-1fcdC:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 6 VAL A 150
ILE A 340
ALA A 173
LEU A 176
 None
 0.84A 3kk6B-1fcdA:
undetectable		 3kk6B-1fcdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3007_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 9 THR A 134
ALA A 135
LEU A 137
ASN A  46
ARG A 168
 None
None
None
FAD  A 699 (-3.9A)
FAD  A 699 ( 4.3A)
 1.33A 3kp6B-1fcdA:
0.0		 3kp6B-1fcdA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 6 TYR A 306
VAL A 276
VAL A 314
ILE A 362
 None
 1.10A 3pyyA-1fcdA:
undetectable		 3pyyA-1fcdA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 7 ALA A 308
GLY A 105
ILE A 106
THR A  41
 FAD  A 699 ( 3.8A)
FAD  A 699 (-3.6A)
None
None
 0.78A 3spkB-1fcdA:
0.0		 3spkB-1fcdA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		3 / 3 LYS A 260
ARG A 160
LEU A 108
 None
FAD  A 699 (-3.1A)
None
 1.29A 3v4tE-1fcdA:
1.5		 3v4tE-1fcdA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NPT_A_017A401_1
(PROTEASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 9 ALA A 173
ILE A  49
ILE A 340
ILE A 187
VAL A 185
 None
 1.04A 4nptA-1fcdA:
0.0		 4nptA-1fcdA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)
(Allochromatium
vinosum) 		5 / 12 ILE C  53
ILE C 120
GLY C  19
ILE C  29
ASN C  10
 HEM  C 901 (-4.4A)
None
None
HEM  C 901 (-4.4A)
None
 1.05A 4o1eA-1fcdC:
undetectable		 4o1eA-1fcdC:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_B_C2FB4000_0
(DIHYDROPTEROATE
SYNTHASE DHPS)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)
(Allochromatium
vinosum) 		5 / 12 ILE C  53
ILE C 120
GLY C  19
ILE C  29
ASN C  10
 HEM  C 901 (-4.4A)
None
None
HEM  C 901 (-4.4A)
None
 1.01A 4o1eB-1fcdC:
undetectable		 4o1eB-1fcdC:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 12 GLY A  10
ALA A  18
ILE A 289
SER A 283
PRO A 104
 None
None
None
None
FAD  A 699 (-4.5A)
 0.75A 4rtmA-1fcdA:
undetectable		 4rtmA-1fcdA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT8_A_TMQA302_1
(RV2671)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 12 ILE A 352
SER A 368
GLY A 369
ALA A 351
GLU A 363
 None
 1.23A 4xt8A-1fcdA:
undetectable		 4xt8A-1fcdA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 5 ARG A 257
GLY A 259
GLU A 107
SER A 283
 None
 1.21A 4z3oA-1fcdA:
undetectable
4z3oB-1fcdA:
undetectable		 4z3oA-1fcdA:
20.59
4z3oB-1fcdA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 8 ALA A 103
VAL A   7
GLY A  13
ALA A 308
GLY A 312
 None
None
FAD  A 699 (-3.4A)
FAD  A 699 ( 3.8A)
None
 1.32A 4zjzB-1fcdA:
undetectable		 4zjzB-1fcdA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_B_BEZB601_0
(BENZOATE-COENZYME A
LIGASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 8 ALA A 103
VAL A 101
GLY A  13
ALA A 308
GLY A 312
 None
None
FAD  A 699 (-3.4A)
FAD  A 699 ( 3.8A)
None
 1.13A 4zjzB-1fcdA:
undetectable		 4zjzB-1fcdA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 7 SER A 283
ARG A 257
GLY A 259
GLU A 107
 None
 0.95A 5btaA-1fcdA:
undetectable
5btaC-1fcdA:
0.0
5btaD-1fcdA:
undetectable		 5btaA-1fcdA:
22.28
5btaC-1fcdA:
22.28
5btaD-1fcdA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 6 SER A 283
ARG A 257
GLY A 259
GLU A 107
 None
 0.96A 5btaA-1fcdA:
undetectable
5btaB-1fcdA:
undetectable
5btaC-1fcdA:
undetectable		 5btaA-1fcdA:
22.28
5btaB-1fcdA:
22.06
5btaC-1fcdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 6 SER A 283
ARG A 257
GLY A 259
GLU A 107
 None
 0.97A 5btcA-1fcdA:
undetectable
5btcC-1fcdA:
undetectable
5btcD-1fcdA:
undetectable		 5btcA-1fcdA:
22.28
5btcC-1fcdA:
22.28
5btcD-1fcdA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTC_G_CPFG102_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 6 SER A 283
ARG A 257
GLY A 259
GLU A 107
 None
 0.94A 5btcA-1fcdA:
undetectable
5btcB-1fcdA:
undetectable
5btcC-1fcdA:
undetectable		 5btcA-1fcdA:
22.28
5btcB-1fcdA:
22.06
5btcC-1fcdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 7 SER A 283
ARG A 257
GLY A 259
GLU A 107
 None
 0.98A 5btfA-1fcdA:
0.0
5btfB-1fcdA:
undetectable
5btfC-1fcdA:
0.0		 5btfA-1fcdA:
22.28
5btfB-1fcdA:
22.06
5btfC-1fcdA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 7 SER A 283
ARG A 257
GLY A 259
GLU A 107
 None
 1.02A 5btfA-1fcdA:
undetectable
5btfC-1fcdA:
0.0
5btfD-1fcdA:
undetectable		 5btfA-1fcdA:
22.28
5btfC-1fcdA:
22.28
5btfD-1fcdA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		3 / 3 TYR A 338
TYR A 353
SER A 307
 None
 0.85A 5iktB-1fcdA:
0.0		 5iktB-1fcdA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_H_Z80H401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 10 ILE A  80
ILE A 261
VAL A  87
THR A  89
ILE A  33
 None
FAD  A 699 (-3.7A)
None
None
FAD  A 699 (-4.7A)
 1.09A 5lg3H-1fcdA:
undetectable		 5lg3H-1fcdA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)
(Allochromatium
vinosum) 		4 / 5 SER C 172
ALA C 171
GLN C 124
THR C 126
 None
None
HEM  C 901 ( 4.7A)
None
 1.39A 5n0tA-1fcdC:
undetectable		 5n0tA-1fcdC:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		4 / 8 VAL A 172
LEU A 137
THR A 134
ALA A 127
 None
 0.90A 5tt3H-1fcdA:
undetectable		 5tt3H-1fcdA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		3 / 3 ARG A  53
ILE A  58
SER A  57
 None
 0.71A 5zw2A-1fcdA:
0.0		 5zw2A-1fcdA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 12 GLY A 233
GLY A 232
VAL A 237
GLN A 140
GLY A 115
 None
 1.06A 6gneA-1fcdA:
2.3		 6gneA-1fcdA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 12 GLY A 233
GLY A 232
VAL A 237
GLN A 140
GLY A 115
 None
 1.07A 6gneB-1fcdA:
2.2		 6gneB-1fcdA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)
FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 12 VAL C  22
TYR A 338
TYR A 306
PRO A 302
GLY C  19
 None
 1.40A 6gngB-1fcdC:
undetectable		 6gngB-1fcdC:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)
(Allochromatium
vinosum) 		5 / 9 ILE A  80
ILE A 264
GLU A 282
VAL A 102
ILE A 261
 None
None
None
None
FAD  A 699 (-3.7A)
 1.00A 6hloA-1fcdA:
4.1		 6hloA-1fcdA:
21.67