SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 8 LEU A 595
VAL A 539
LEU A 570
ALA A 545
 None
 0.92A 1fiqC-1fchA:
undetectable		 1fiqC-1fchA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 7 LEU A 595
SER A 592
ASP A 590
PHE A 598
 None
 1.27A 1ismB-1fchA:
undetectable		 1ismB-1fchA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 343
ARG A 520
LEU A 359
ILE A 388
MET A 332
 None
 1.45A 1y0xX-1fchA:
undetectable		 1y0xX-1fchA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 8 GLY A 458
THR A 475
ALA A 476
ALA A 477
 None
 0.56A 2ej3C-1fchA:
undetectable		 2ej3C-1fchA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		5 / 10 SER A 521
TYR A 508
ALA A 511
ASN A 489
ALA A 507
 None
 1.43A 2r2vC-1fchA:
0.0
2r2vF-1fchA:
0.0
2r2vG-1fchA:
undetectable		 2r2vC-1fchA:
7.42
2r2vF-1fchA:
7.42
2r2vG-1fchA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_B_SAMB206_0
(UPF0217 PROTEIN
MJ1640)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 5 SER A 375
LEU A 350
GLY A 339
GLU A 348
 None
 1.22A 3aiaA-1fchA:
undetectable
3aiaB-1fchA:
undetectable		 3aiaA-1fchA:
16.30
3aiaB-1fchA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_A_CHDA3_0
(FERROCHELATASE)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 PRO A 294
LEU A 295
ARG A 308
 None
 0.90A 3aqiA-1fchA:
undetectable		 3aqiA-1fchA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 PRO A 294
LEU A 295
ARG A 308
 None
 0.79A 3aqiB-1fchA:
0.5		 3aqiB-1fchA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		5 / 12 LEU A 457
LEU A 460
LEU A 463
GLN A 382
LEU A 430
 None
 1.32A 3d90B-1fchA:
undetectable		 3d90B-1fchA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 7 LEU A 487
GLN A 366
LEU A 355
VAL A 374
 None
 0.84A 3g8iA-1fchA:
0.0		 3g8iA-1fchA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 LEU A 600
PRO A 601
LEU A 595
 None
 0.49A 3hcrA-1fchA:
undetectable		 3hcrA-1fchA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 8 ASN A 378
THR A 377
LEU A 463
ASN A 524
 None
 1.16A 3kp2A-1fchA:
0.1
3kp2B-1fchA:
undetectable		 3kp2A-1fchA:
17.03
3kp2B-1fchA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 5 LEU A 577
GLY A 578
PHE A 598
ARG A 536
 None
 0.99A 3smtA-1fchA:
0.0		 3smtA-1fchA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 6 TYR A 518
GLN A 515
GLN A 549
GLU A 322
 None
 1.12A 4azvA-1fchA:
undetectable		 4azvA-1fchA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_D_MIXD101_1
(DNA TOPOISOMERASE
2-BETA)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 6 ARG A 308
GLY A 305
ASN A 293
GLN A 515
 None
 1.15A 4g0vB-1fchA:
undetectable		 4g0vB-1fchA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		3 / 3 MET A 370
GLN A 384
TYR A 283
 None
 1.02A 4udcA-1fchA:
0.1		 4udcA-1fchA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_A_AZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		5 / 11 VAL A 453
LEU A 393
THR A 396
ALA A 400
TRP A 392
 None
 1.34A 4ygfA-1fchA:
undetectable		 4ygfA-1fchA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YGF_C_AZMC303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		5 / 11 VAL A 453
LEU A 393
THR A 396
ALA A 400
TRP A 392
 None
 1.41A 4ygfC-1fchA:
undetectable		 4ygfC-1fchA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_A_MZMA303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		5 / 12 VAL A 453
LEU A 393
THR A 396
ALA A 400
TRP A 392
 None
 1.32A 4yhaA-1fchA:
undetectable		 4yhaA-1fchA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DWK_C_ACTC207_0
(DIACYLGLYCEROL
KINASE)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		4 / 5 GLU A 346
ALA A 343
GLU A 348
ASN A 378
 None
 0.93A 5dwkC-1fchA:
undetectable		 5dwkC-1fchA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		5 / 12 ALA A 373
LEU A 372
ALA A 371
THR A 340
LEU A 486
 None
 1.18A 5k9dA-1fchA:
0.0		 5k9dA-1fchA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_G_EZLG303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		5 / 9 VAL A 453
LEU A 393
THR A 396
ALA A 400
TRP A 392
 None
 1.35A 5tt3G-1fchA:
undetectable		 5tt3G-1fchA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 1fch PEROXISOMAL
TARGETING SIGNAL 1
RECEPTOR
(Homo
sapiens) 		5 / 12 ILE A 527
GLY A 492
ALA A 496
ALA A 507
ALA A 506
 None
 0.91A 5zw4A-1fchA:
undetectable		 5zw4A-1fchA:
22.01