SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fcu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA6_0
(GRAMICIDIN A)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		3 / 3 ALA A  73
VAL A  78
TRP A 115
 None
 0.97A 1gmkA-1fcuA:
undetectable
1gmkB-1fcuA:
undetectable		 1gmkA-1fcuA:
7.14
1gmkB-1fcuA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKV_A_EFZA2000_1
(POL POLYPROTEIN)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		5 / 9 LEU A 324
VAL A  17
GLY A 302
LEU A 278
TYR A 319
 None
 1.12A 1ikvA-1fcuA:
0.5		 1ikvA-1fcuA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKW_A_EFZA2000_1
(POL POLYPROTEIN)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		5 / 10 LEU A 324
VAL A  17
GLY A 302
LEU A 278
TYR A 319
 None
 1.08A 1ikwA-1fcuA:
undetectable		 1ikwA-1fcuA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		5 / 11 LEU A 324
VAL A  17
GLY A 302
LEU A 278
TYR A 319
 None
 1.24A 1lwcA-1fcuA:
undetectable		 1lwcA-1fcuA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		4 / 6 ASN A  16
GLY A 182
ILE A 110
ILE A  51
 None
 0.89A 1n49D-1fcuA:
undetectable		 1n49D-1fcuA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VRT_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		5 / 9 LEU A 324
VAL A  17
GLY A 302
LEU A 278
TYR A 319
 None
 1.20A 1vrtA-1fcuA:
0.0		 1vrtA-1fcuA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		4 / 6 GLU A 323
TYR A 319
ASP A 282
ARG A 237
 None
 1.05A 2a3bB-1fcuA:
4.3		 2a3bB-1fcuA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		3 / 3 ASN A 321
ARG A 317
ASP A  44
 None
 0.90A 2qe6A-1fcuA:
undetectable		 2qe6A-1fcuA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		3 / 3 ASN A 321
ARG A 317
ASP A  44
 None
 0.91A 2qe6B-1fcuA:
undetectable		 2qe6B-1fcuA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP0_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		5 / 9 LEU A 324
VAL A  17
GLY A 302
LEU A 278
TYR A 319
 None
 1.16A 3lp0A-1fcuA:
0.0		 3lp0A-1fcuA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_C_DR7C100_1
(HIV-1 PROTEASE)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		5 / 12 GLY A 294
ALA A 295
ASP A 296
VAL A 241
ILE A 290
 None
 1.03A 3oxxC-1fcuA:
undetectable		 3oxxC-1fcuA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QIP_A_NVPA561_1
(REVERSE HIV-1
REVERSE
TRANSCRIPTASE P66)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		5 / 10 LEU A 324
VAL A  17
GLY A 302
LEU A 278
TYR A 319
 None
 1.16A 3qipA-1fcuA:
undetectable		 3qipA-1fcuA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		5 / 11 ALA A 248
TYR A  14
ILE A 299
GLY A 297
ALA A 295
 None
 1.20A 3rukD-1fcuA:
undetectable		 3rukD-1fcuA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		4 / 8 LEU A 320
LEU A 324
GLY A 325
VAL A  13
 None
 0.87A 4c9nA-1fcuA:
0.0		 4c9nA-1fcuA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMM_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		4 / 5 MET A 165
LEU A 215
ARG A 116
PRO A  57
 None
 1.19A 4kmmB-1fcuA:
undetectable		 4kmmB-1fcuA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCL_B_SAMB301_0
(O-METHYLTRANSFERASE
FAMILY PROTEIN)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		5 / 12 GLN A  40
LEU A  39
GLU A  49
GLY A  48
ALA A  52
 None
 1.10A 4pclB-1fcuA:
undetectable		 4pclB-1fcuA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		4 / 7 ASN A  75
PHE A  60
TRP A 115
TYR A 129
 None
 1.34A 4v2yB-1fcuA:
0.0		 4v2yB-1fcuA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		3 / 3 VAL A 245
LEU A 249
VAL A 262
 None
 0.50A 4wq4A-1fcuA:
2.7		 4wq4A-1fcuA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		3 / 3 TYR A 160
ARG A 155
LYS A 159
 None
 1.21A 4wq5B-1fcuA:
2.5		 4wq5B-1fcuA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		4 / 8 ASP A 210
GLU A 208
ILE A 118
TYR A 190
 None
 1.03A 4xjeA-1fcuA:
0.0		 4xjeA-1fcuA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		4 / 7 VAL A  17
TRP A  15
ILE A  38
LEU A 278
 None
 1.24A 4xo7B-1fcuA:
2.7		 4xo7B-1fcuA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		5 / 12 TYR A 268
LEU A 320
VAL A  32
ILE A  38
LEU A 283
 None
 1.38A 4yvpB-1fcuA:
7.7		 4yvpB-1fcuA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		5 / 12 TYR A 268
TYR A 319
VAL A  32
ILE A  38
LEU A 287
 None
 1.38A 4yvpB-1fcuA:
7.7		 4yvpB-1fcuA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMJ_A_EF2A151_1
(CEREBLON ISOFORM 4)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		4 / 7 ASN A  75
PHE A  60
TRP A 115
TYR A 129
 None
 1.28A 5amjA-1fcuA:
0.0		 5amjA-1fcuA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_A_EF2A151_1
(CEREBLON ISOFORM 4)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		4 / 8 ASN A  75
PHE A  60
TRP A 115
TYR A 129
 None
 1.10A 5amkA-1fcuA:
0.0		 5amkA-1fcuA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		4 / 8 ASP A 210
GLU A 208
ILE A 118
TYR A 190
 None
 0.98A 5cfsA-1fcuA:
0.0		 5cfsA-1fcuA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PBE_A_TYLA2001_1
(BROMODOMAIN ADJACENT
TO ZINC FINGER
DOMAIN PROTEIN 2B)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		4 / 6 PRO A 264
VAL A  13
VAL A 328
ILE A 290
 None
 0.94A 5pbeA-1fcuA:
undetectable		 5pbeA-1fcuA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BER_A_DVAA2_0
(E(DVA)DP(DGL)(DHI)(D
PR)N(DAL)(DPR))		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		3 / 3 GLU A  49
ASP A 101
PRO A 100
 None
 0.68A 6berA-1fcuA:
undetectable		 6berA-1fcuA:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 1fcu HYALURONOGLUCOSAMINI
DASE
(Apis
mellifera) 		3 / 3 LEU A 314
LEU A  27
ARG A 317
 None
 0.64A 6fgdA-1fcuA:
undetectable		 6fgdA-1fcuA:
24.15