SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fd9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 9 ASP A 142
PHE A 153
ILE A 159
TRP A 162
TYR A 185
PHE A 202
None
1.17A 1bkfA-1fd9A:
16.1
1bkfA-1fd9A:
35.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 9 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
PHE A 202
None
0.57A 1bkfA-1fd9A:
16.1
1bkfA-1fd9A:
35.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 12 ASP A 142
PHE A 153
ILE A 159
TYR A 185
ILE A 194
PHE A 202
None
1.14A 1c9hA-1fd9A:
15.7
1c9hA-1fd9A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9H_A_RAPA108_1
(FKBP12.6)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 12 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TYR A 185
ILE A 194
PHE A 202
None
0.54A 1c9hA-1fd9A:
15.7
1c9hA-1fd9A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
4 / 6 LEU A  92
ILE A 136
GLU A 198
PRO A 180
None
1.15A 1ditH-1fd9A:
0.0
1ditP-1fd9A:
undetectable
1ditH-1fd9A:
19.49
1ditP-1fd9A:
6.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 12 ASP A 142
PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.07A 1fapA-1fd9A:
16.4
1fapA-1fd9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 12 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.54A 1fapA-1fd9A:
16.4
1fapA-1fd9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FAP_A_RAPA108_1
(FK506-BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
5 / 12 TYR A 131
VAL A 158
TRP A 162
ILE A 194
PHE A 202
None
1.05A 1fapA-1fd9A:
16.4
1fapA-1fd9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 12 ASP A 142
PHE A 153
ILE A 159
TRP A 162
TYR A 185
PHE A 202
None
1.17A 1fkbA-1fd9A:
16.2
1fkbA-1fd9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKB_A_RAPA108_1
(FK506 BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 12 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
PHE A 202
None
0.59A 1fkbA-1fd9A:
16.2
1fkbA-1fd9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.13A 1fkfA-1fd9A:
16.0
1fkfA-1fd9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKF_A_FK5A108_1
(FK506 BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.54A 1fkfA-1fd9A:
16.0
1fkfA-1fd9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.12A 1fkjA-1fd9A:
16.0
1fkjA-1fd9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKJ_A_FK5A108_1
(FK506 BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.54A 1fkjA-1fd9A:
16.0
1fkjA-1fd9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 12 ASP A 142
PHE A 153
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.16A 1fklA-1fd9A:
16.0
1fklA-1fd9A:
35.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FKL_A_RAPA108_1
(FK506 BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 12 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.63A 1fklA-1fd9A:
16.0
1fklA-1fd9A:
35.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 12 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.63A 1pbkA-1fd9A:
15.9
1pbkA-1fd9A:
24.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q6I_A_FK5A301_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 9 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.55A 1q6iA-1fd9A:
23.5
1q6iA-1fd9A:
37.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 10 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.47A 1q6iB-1fd9A:
23.1
1q6iB-1fd9A:
37.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.13A 1tcoC-1fd9A:
15.9
1tcoC-1fd9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TCO_C_FK5C509_2
(FK506-BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.63A 1tcoC-1fd9A:
15.9
1tcoC-1fd9A:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
4 / 6 MET A  38
MET A  58
VAL A  61
LEU A  62
None
0.91A 1x8vA-1fd9A:
0.0
1x8vA-1fd9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.13A 1yatA-1fd9A:
18.2
1yatA-1fd9A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAT_A_FK5A108_1
(FK506 BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.59A 1yatA-1fd9A:
18.2
1yatA-1fd9A:
23.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 ASP A 142
PHE A 153
ILE A 159
TRP A 162
TYR A 185
PHE A 202
None
1.16A 2dg3A-1fd9A:
16.1
2dg3A-1fd9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG3_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
PHE A 202
None
0.54A 2dg3A-1fd9A:
16.1
2dg3A-1fd9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG4_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TYR A 185
PHE A 202
None
0.56A 2dg4A-1fd9A:
15.7
2dg4A-1fd9A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TYR A 185
PHE A 202
None
0.57A 2dg9A-1fd9A:
15.9
2dg9A-1fd9A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.13A 2fkeA-1fd9A:
16.1
2fkeA-1fd9A:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2FKE_A_FK5A108_1
(FK506 BINDING
PROTEIN)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.53A 2fkeA-1fd9A:
16.1
2fkeA-1fd9A:
34.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
3 / 3 GLN A  56
LYS A  59
VAL A  61
None
0.87A 2jfaB-1fd9A:
undetectable
2jfaB-1fd9A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
4 / 6 LEU A 183
TRP A 175
MET A 169
LEU A 166
None
1.28A 2oz7A-1fd9A:
undetectable
2oz7A-1fd9A:
18.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
5 / 11 TYR A 131
ASP A 142
PHE A 153
GLN A 154
TRP A 162
None
1.30A 2vcdA-1fd9A:
20.3
2vcdA-1fd9A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VCD_A_RAPA138_1
(OUTER MEMBRANE
PROTEIN MIP)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
10 / 11 TYR A 131
PHE A 141
ASP A 142
PHE A 153
GLN A 157
VAL A 158
ILE A 159
PRO A 160
TRP A 162
TYR A 185
None
0.93A 2vcdA-1fd9A:
20.3
2vcdA-1fd9A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 PHE A 141
PHE A 153
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.18A 2vn1A-1fd9A:
17.4
2vn1A-1fd9A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
PHE A 141
ASP A 142
VAL A 158
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.75A 2vn1A-1fd9A:
17.4
2vn1A-1fd9A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
5 / 10 PHE A 153
ILE A 159
TRP A 162
TYR A 185
PHE A 202
None
1.20A 2vn1B-1fd9A:
17.4
2vn1B-1fd9A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_B_FK5B501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 10 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
PHE A 202
None
0.68A 2vn1B-1fd9A:
17.4
2vn1B-1fd9A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
5 / 12 GLU A  89
LEU A  92
LEU A 108
GLY A 186
SER A 181
None
1.07A 3g2oB-1fd9A:
undetectable
3g2oB-1fd9A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCP_B_CHDB4_0
(FERROCHELATASE,
MITOCHONDRIAL)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
3 / 3 GLY A 118
PRO A 121
LEU A 206
None
0.58A 3hcpB-1fd9A:
undetectable
3hcpB-1fd9A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 10 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.10A 3ihzA-1fd9A:
17.1
3ihzA-1fd9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_1
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 10 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.50A 3ihzA-1fd9A:
17.1
3ihzA-1fd9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
5 / 8 PHE A 153
TRP A 162
TYR A 185
GLY A 191
ILE A 194
None
1.31A 3ihzB-1fd9A:
17.6
3ihzB-1fd9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
5 / 8 PHE A 153
TRP A 162
TYR A 185
GLY A 192
ILE A 194
None
1.40A 3ihzB-1fd9A:
17.6
3ihzB-1fd9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 8 TYR A 131
ASP A 142
TRP A 162
TYR A 185
GLY A 191
ILE A 194
None
0.76A 3ihzB-1fd9A:
17.6
3ihzB-1fd9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
5 / 8 TYR A 131
TRP A 162
TYR A 185
GLY A 192
ILE A 194
None
0.92A 3ihzB-1fd9A:
17.6
3ihzB-1fd9A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KZ7_A_RAPA225_1
(FK506-BINDING
PROTEIN 3)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 10 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.58A 3kz7A-1fd9A:
16.0
3kz7A-1fd9A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.12A 3o5rA-1fd9A:
17.1
3o5rA-1fd9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O5R_A_FK5A1001_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.53A 3o5rA-1fd9A:
17.1
3o5rA-1fd9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 10 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.11A 3uf8A-1fd9A:
18.4
3uf8A-1fd9A:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UF8_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 10 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.57A 3uf8A-1fd9A:
18.4
3uf8A-1fd9A:
29.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 10 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.11A 3uqaA-1fd9A:
18.3
3uqaA-1fd9A:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3UQA_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 10 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.58A 3uqaA-1fd9A:
18.3
3uqaA-1fd9A:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
5 / 8 PHE A 153
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.15A 3uqbA-1fd9A:
18.1
3uqbA-1fd9A:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 8 TYR A 131
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.43A 3uqbA-1fd9A:
18.1
3uqbA-1fd9A:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.14A 3vawA-1fd9A:
17.5
3vawA-1fd9A:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAW_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN
SMT3,PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.59A 3vawA-1fd9A:
17.5
3vawA-1fd9A:
29.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 12 ASP A 142
GLN A 157
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.93A 4drhA-1fd9A:
16.1
4drhA-1fd9A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 12 ASP A 142
PHE A 153
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.13A 4drhA-1fd9A:
16.1
4drhA-1fd9A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 12 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.63A 4drhA-1fd9A:
16.1
4drhA-1fd9A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 12 ASP A 142
GLN A 157
VAL A 158
ILE A 159
TYR A 185
ILE A 194
PHE A 202
None
1.00A 4drhD-1fd9A:
16.2
4drhD-1fd9A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 12 ASP A 142
PHE A 153
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.13A 4drhD-1fd9A:
16.2
4drhD-1fd9A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRH_D_RAPD201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 12 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.60A 4drhD-1fd9A:
16.2
4drhD-1fd9A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 ASP A 142
PHE A 153
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.10A 4driA-1fd9A:
17.5
4driA-1fd9A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRI_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
9 / 11 TYR A 131
ASP A 142
GLN A 157
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.86A 4driA-1fd9A:
17.5
4driA-1fd9A:
25.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 11 ASP A 142
PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.08A 4drjA-1fd9A:
16.9
4drjA-1fd9A:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.55A 4drjA-1fd9A:
16.9
4drjA-1fd9A:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.12A 4dz2A-1fd9A:
18.2
4dz2B-1fd9A:
18.2
4dz2A-1fd9A:
21.80
4dz2B-1fd9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_A_FK5A200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.58A 4dz2A-1fd9A:
18.2
4dz2B-1fd9A:
18.2
4dz2A-1fd9A:
21.80
4dz2B-1fd9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.12A 4dz2A-1fd9A:
18.2
4dz2B-1fd9A:
18.2
4dz2A-1fd9A:
21.80
4dz2B-1fd9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ2_B_FK5B200_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.57A 4dz2A-1fd9A:
18.2
4dz2B-1fd9A:
18.2
4dz2A-1fd9A:
21.80
4dz2B-1fd9A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 10 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.11A 4dz3A-1fd9A:
18.2
4dz3A-1fd9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 10 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.57A 4dz3A-1fd9A:
18.2
4dz3A-1fd9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 10 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.13A 4dz3B-1fd9A:
18.2
4dz3B-1fd9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DZ3_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 10 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.59A 4dz3B-1fd9A:
18.2
4dz3B-1fd9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 10 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.09A 4laxA-1fd9A:
17.0
4laxA-1fd9A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAX_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 10 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.57A 4laxA-1fd9A:
17.0
4laxA-1fd9A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 12 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.11A 4nnrA-1fd9A:
13.2
4nnrB-1fd9A:
13.2
4nnrA-1fd9A:
25.81
4nnrB-1fd9A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 12 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.59A 4nnrA-1fd9A:
13.2
4nnrB-1fd9A:
13.2
4nnrA-1fd9A:
25.81
4nnrB-1fd9A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 10 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.14A 4nnrB-1fd9A:
13.2
4nnrB-1fd9A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 10 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.67A 4nnrB-1fd9A:
13.2
4nnrB-1fd9A:
25.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
5 / 10 TYR A 131
ASP A 142
ILE A 159
TYR A 185
PHE A 202
None
0.64A 4odoA-1fd9A:
10.1
4odoA-1fd9A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
5 / 10 TYR A 131
ASP A 142
ILE A 159
TYR A 185
PHE A 202
None
0.61A 4odoB-1fd9A:
9.8
4odoB-1fd9A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_C_FK5C204_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
5 / 10 TYR A 131
ASP A 142
ILE A 159
TYR A 185
PHE A 202
None
0.64A 4odoC-1fd9A:
9.7
4odoC-1fd9A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_A_FK5A201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 12 TYR A 131
ASP A 142
ILE A 159
TYR A 185
ILE A 194
PHE A 202
None
0.65A 4odrA-1fd9A:
11.0
4odrB-1fd9A:
11.1
4odrA-1fd9A:
19.15
4odrB-1fd9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
5 / 11 TYR A 131
ASP A 142
ILE A 159
TYR A 185
PHE A 202
None
0.62A 4odrA-1fd9A:
11.0
4odrB-1fd9A:
11.1
4odrA-1fd9A:
19.15
4odrB-1fd9A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 10 ASP A 142
PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.11A 4qt2A-1fd9A:
17.3
4qt2A-1fd9A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT2_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 10 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.62A 4qt2A-1fd9A:
17.3
4qt2A-1fd9A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 10 ASP A 142
PHE A 153
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.11A 4qt3A-1fd9A:
16.2
4qt3A-1fd9A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QT3_A_RAPA202_1
(FK506-BINDING
PROTEIN (FKBP)-TYPE
PEPTIDYL-PROPYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 10 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.58A 4qt3A-1fd9A:
16.2
4qt3A-1fd9A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 12 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.14A 5b8iC-1fd9A:
15.7
5b8iC-1fd9A:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 12 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.62A 5b8iC-1fd9A:
15.7
5b8iC-1fd9A:
26.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.52A 5d75A-1fd9A:
16.5
5d75A-1fd9A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.58A 5gpgA-1fd9A:
17.0
5gpgA-1fd9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 12 ASP A 142
PHE A 153
ILE A 159
TYR A 185
ILE A 194
PHE A 202
None
1.14A 5hkgA-1fd9A:
15.8
5hkgA-1fd9A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HKG_A_RAPA201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1B)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 12 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TYR A 185
ILE A 194
PHE A 202
None
0.55A 5hkgA-1fd9A:
15.8
5hkgA-1fd9A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
5 / 11 PHE A 153
ILE A 159
TRP A 162
TYR A 185
PHE A 202
None
1.20A 5huaA-1fd9A:
18.3
5huaA-1fd9A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
PHE A 202
None
0.54A 5huaA-1fd9A:
18.3
5huaA-1fd9A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 ASP A 142
PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
None
1.20A 5hw8A-1fd9A:
15.5
5hw8D-1fd9A:
15.6
5hw8A-1fd9A:
23.11
5hw8D-1fd9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
None
0.66A 5hw8A-1fd9A:
15.5
5hw8D-1fd9A:
15.6
5hw8A-1fd9A:
23.11
5hw8D-1fd9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 ASP A 142
PHE A 153
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.14A 5hw8B-1fd9A:
15.7
5hw8B-1fd9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_B_FK5B201_1
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 11 TYR A 131
ASP A 142
VAL A 158
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.59A 5hw8B-1fd9A:
15.7
5hw8B-1fd9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_C_FK5C201_1
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 10 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
LEU A 200
PHE A 202
None
0.56A 5hw8C-1fd9A:
15.8
5hw8H-1fd9A:
13.0
5hw8C-1fd9A:
23.11
5hw8H-1fd9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.12A 5hw8D-1fd9A:
15.6
5hw8D-1fd9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_D_FK5D201_1
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.61A 5hw8D-1fd9A:
15.6
5hw8D-1fd9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
5 / 11 PHE A 153
ILE A 159
TRP A 162
TYR A 185
PHE A 202
None
1.23A 5hw8E-1fd9A:
15.5
5hw8E-1fd9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_E_FK5E201_1
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
PHE A 202
None
0.69A 5hw8E-1fd9A:
15.5
5hw8E-1fd9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 12 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TYR A 185
PHE A 202
None
0.65A 5hw8B-1fd9A:
15.7
5hw8F-1fd9A:
12.8
5hw8G-1fd9A:
15.4
5hw8B-1fd9A:
23.11
5hw8F-1fd9A:
23.11
5hw8G-1fd9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_F_FK5F201_1
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 12 TYR A 131
VAL A 158
ILE A 159
TRP A 162
TYR A 185
PHE A 202
None
0.41A 5hw8B-1fd9A:
15.7
5hw8F-1fd9A:
12.8
5hw8G-1fd9A:
15.4
5hw8B-1fd9A:
23.11
5hw8F-1fd9A:
23.11
5hw8G-1fd9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.08A 5hw8G-1fd9A:
15.4
5hw8G-1fd9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_2
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.61A 5hw8G-1fd9A:
15.4
5hw8G-1fd9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 8 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
PHE A 202
None
0.77A 5hw8H-1fd9A:
13.0
5hw8H-1fd9A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 11 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.13A 5hwcA-1fd9A:
16.7
5hwcA-1fd9A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWC_A_FK5A201_1
(FK506-BINDING
PROTEIN 1A)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 11 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.58A 5hwcA-1fd9A:
16.7
5hwcA-1fd9A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
4 / 8 GLN A 167
GLY A 161
ILE A 204
TRP A 175
None
0.82A 5vlmH-1fd9A:
undetectable
5vlmH-1fd9A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
3 / 3 GLN A 157
ILE A 207
HIS A 205
None
ZN  A 402 ( 4.8A)
ZN  A 402 (-3.4A)
0.69A 5z12B-1fd9A:
undetectable
5z12B-1fd9A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
4 / 6 GLY A 192
ASP A 142
GLY A 195
PRO A 196
None
0.63A 6ag0C-1fd9A:
undetectable
6ag0C-1fd9A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 12 ASP A 142
PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.08A 6mkeA-1fd9A:
17.7
6mkeD-1fd9A:
17.7
6mkeA-1fd9A:
27.34
6mkeD-1fd9A:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_A_FK5A201_0
(PEPTIDYLPROLYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 12 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.54A 6mkeA-1fd9A:
17.7
6mkeD-1fd9A:
17.7
6mkeA-1fd9A:
27.34
6mkeD-1fd9A:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
6 / 12 PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.11A 6mkeB-1fd9A:
17.8
6mkeC-1fd9A:
17.6
6mkeB-1fd9A:
27.34
6mkeC-1fd9A:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 12 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.53A 6mkeB-1fd9A:
17.8
6mkeC-1fd9A:
17.6
6mkeB-1fd9A:
27.34
6mkeC-1fd9A:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 10 ASP A 142
PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.06A 6mkeC-1fd9A:
17.6
6mkeC-1fd9A:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_1
(PEPTIDYLPROLYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 10 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.56A 6mkeC-1fd9A:
17.6
6mkeC-1fd9A:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
7 / 10 ASP A 142
PHE A 153
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
1.05A 6mkeD-1fd9A:
17.7
6mkeD-1fd9A:
27.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_1
(PEPTIDYLPROLYL
ISOMERASE)
1fd9 PROTEIN (MACROPHAGE
INFECTIVITY
POTENTIATOR PROTEIN)

(Legionella
pneumophila)
8 / 10 TYR A 131
ASP A 142
VAL A 158
ILE A 159
TRP A 162
TYR A 185
ILE A 194
PHE A 202
None
0.54A 6mkeD-1fd9A:
17.7
6mkeD-1fd9A:
27.34