SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fdj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 4 THR A1205
LEU A1209
VAL A1212
LEU A1216
 None
 0.48A 1fbmB-1fdjA:
0.0		 1fbmB-1fdjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 4 THR A1205
LEU A1209
VAL A1212
LEU A1216
 None
 0.55A 1fbmD-1fdjA:
0.0		 1fbmD-1fdjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 5 THR A1205
LEU A1209
VAL A1212
LEU A1216
 None
 0.49A 1fbmE-1fdjA:
undetectable		 1fbmE-1fdjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		5 / 11 GLU A1187
LEU A1270
ILE A1185
TYR A1213
THR A1205
 2FP  A5001 (-4.3A)
2FP  A5001 ( 3.9A)
None
None
None
 1.19A 1jomA-1fdjA:
undetectable		 1jomA-1fdjA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		3 / 3 THR A1205
LEU A1209
LEU A1216
 None
 0.63A 1mz9C-1fdjA:
undetectable		 1mz9C-1fdjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 4 THR A1205
LEU A1209
VAL A1212
LEU A1216
 None
 0.64A 1mz9D-1fdjA:
undetectable		 1mz9D-1fdjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		3 / 3 THR A1205
LEU A1209
VAL A1212
 None
 0.67A 1mz9E-1fdjA:
undetectable		 1mz9E-1fdjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		5 / 10 LEU A1209
VAL A1264
VAL A1186
PRO A1294
LEU A1256
 None
 1.31A 1sv5A-1fdjA:
0.0		 1sv5A-1fdjA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC1383_1
(CES1 PROTEIN)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 5 TRP A1295
PRO A1261
LEU A1223
GLY A1225
 None
 1.30A 1ya4C-1fdjA:
1.3		 1ya4C-1fdjA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 8 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 0.90A 2dyrC-1fdjA:
undetectable
2dyrJ-1fdjA:
undetectable		 2dyrC-1fdjA:
18.85
2dyrJ-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 7 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 0.95A 2eikC-1fdjA:
undetectable
2eikJ-1fdjA:
0.0		 2eikC-1fdjA:
18.85
2eikJ-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		5 / 8 LEU A1062
ALA A1331
ILE A1069
GLY A1028
ILE A1029
 None
 1.37A 2o4nB-1fdjA:
undetectable		 2o4nB-1fdjA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W1B_A_DXCA2034_0
(ACRIFLAVIN
RESISTANCE PROTEIN B)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		3 / 3 PHE A1144
SER A1300
LEU A1030
 None
 0.60A 2w1bA-1fdjA:
0.0		 2w1bA-1fdjA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 6 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 1.12A 3ablP-1fdjA:
undetectable
3ablW-1fdjA:
0.0		 3ablP-1fdjA:
18.85
3ablW-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 7 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 0.91A 3asnC-1fdjA:
undetectable
3asnJ-1fdjA:
0.0		 3asnC-1fdjA:
18.85
3asnJ-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 8 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 0.91A 3asoC-1fdjA:
undetectable
3asoJ-1fdjA:
0.0		 3asoC-1fdjA:
18.85
3asoJ-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		3 / 3 GLU A1187
LEU A1270
LEU A1030
 2FP  A5001 (-4.3A)
2FP  A5001 ( 3.9A)
None
 0.77A 3ohtB-1fdjA:
undetectable		 3ohtB-1fdjA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		5 / 12 LEU A1062
PHE A1063
GLY A1302
GLU A1034
GLN A1306
 None
None
2FP  A5001 (-3.6A)
None
None
 1.35A 3tbgA-1fdjA:
0.0		 3tbgA-1fdjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		5 / 12 LEU A1062
PHE A1063
GLY A1302
GLU A1034
GLN A1306
 None
None
2FP  A5001 (-3.6A)
None
None
 1.35A 3tbgC-1fdjA:
0.0		 3tbgC-1fdjA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA501_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		5 / 12 THR A1122
VAL A1150
ASP A1193
ILE A1191
GLU A1187
 None
None
None
None
2FP  A5001 (-4.3A)
 1.30A 4i41A-1fdjA:
undetectable		 4i41A-1fdjA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 7 THR A1259
LEU A1151
ASN A1231
LEU A1270
 None
None
None
2FP  A5001 ( 3.9A)
 1.04A 4ib4A-1fdjA:
0.0		 4ib4A-1fdjA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 6 LEU A1283
LEU A1270
THR A1234
VAL A1248
 None
2FP  A5001 ( 3.9A)
None
None
 1.01A 4udaA-1fdjA:
0.0		 4udaA-1fdjA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 6 LEU A1083
LEU A1097
VAL A1104
PHE A1093
 None
 1.22A 4uswA-1fdjA:
0.0		 4uswA-1fdjA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 9 ALA A1309
LEU A1305
LEU A1030
ILE A1069
 None
 0.93A 4xtaA-1fdjA:
undetectable		 4xtaA-1fdjA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 6 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 1.13A 5b1bC-1fdjA:
undetectable
5b1bJ-1fdjA:
0.0		 5b1bC-1fdjA:
18.85
5b1bJ-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 7 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 0.89A 5b1bP-1fdjA:
undetectable
5b1bW-1fdjA:
0.0		 5b1bP-1fdjA:
18.85
5b1bW-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 6 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 1.05A 5z84P-1fdjA:
0.0
5z84W-1fdjA:
0.0		 5z84P-1fdjA:
18.85
5z84W-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 6 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 1.11A 5z85P-1fdjA:
0.0
5z85W-1fdjA:
0.0		 5z85P-1fdjA:
18.85
5z85W-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 6 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 1.00A 5z86C-1fdjA:
undetectable
5z86J-1fdjA:
0.0		 5z86C-1fdjA:
18.85
5z86J-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 6 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 1.01A 5z86P-1fdjA:
undetectable
5z86W-1fdjA:
0.0		 5z86P-1fdjA:
18.85
5z86W-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 6 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 1.04A 5zcoP-1fdjA:
undetectable
5zcoW-1fdjA:
0.0		 5zcoP-1fdjA:
18.85
5zcoW-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 6 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 1.03A 5zcpC-1fdjA:
undetectable
5zcpJ-1fdjA:
0.0		 5zcpC-1fdjA:
18.85
5zcpJ-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 6 GLN A1336
PHE A1299
LEU A1305
PHE A1327
 None
 1.08A 5zcpP-1fdjA:
0.0
5zcpW-1fdjA:
0.0		 5zcpP-1fdjA:
18.85
5zcpW-1fdjA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		3 / 3 ASN A1282
PRO A1245
GLN A1247
 None
 0.92A 6jnhA-1fdjA:
0.9		 6jnhA-1fdjA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA202_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		3 / 3 ASN A1282
PRO A1245
GLN A1247
 None
 0.92A 6jogA-1fdjA:
0.9		 6jogA-1fdjA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA7_A_TPFA602_0
(CYTOCHROME P450 3A4)		 1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE
(Oryctolagus
cuniculus) 		4 / 7 SER A1298
ARG A1021
ILE A1018
ALA A1019
 None
 0.85A 6ma7A-1fdjA:
0.0		 6ma7A-1fdjA:
11.53