SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fdr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 1fdr FLAVODOXIN REDUCTASE
(Escherichia
coli) 		4 / 8 LEU A  67
ASN A  14
LEU A  82
LEU A  22
 FAD  A 249 (-4.5A)
None
None
None
 0.98A 1e7cA-1fdrA:
undetectable		 1e7cA-1fdrA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1fdr FLAVODOXIN REDUCTASE
(Escherichia
coli) 		3 / 3 ARG A 229
VAL A 209
TRP A 110
 None
 1.27A 1qw6A-1fdrA:
0.0		 1qw6A-1fdrA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1fdr FLAVODOXIN REDUCTASE
(Escherichia
coli) 		3 / 3 GLU A 190
GLU A 195
LEU A 181
 None
 0.67A 1v8bA-1fdrA:
3.1		 1v8bA-1fdrA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1fdr FLAVODOXIN REDUCTASE
(Escherichia
coli) 		3 / 3 GLU A 190
GLU A 195
LEU A 181
 None
 0.71A 1v8bB-1fdrA:
3.0		 1v8bB-1fdrA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1fdr FLAVODOXIN REDUCTASE
(Escherichia
coli) 		3 / 3 ARG A 229
VAL A 209
TRP A 110
 None
 1.28A 1vagA-1fdrA:
0.0		 1vagA-1fdrA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 1fdr FLAVODOXIN REDUCTASE
(Escherichia
coli) 		5 / 11 ALA A 117
GLY A 213
ALA A  51
LEU A  19
TYR A  52
 None
None
FAD  A 249 (-3.8A)
None
FAD  A 249 (-4.4A)
 1.21A 3rc0A-1fdrA:
0.0		 3rc0A-1fdrA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_B_SAMB480_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 1fdr FLAVODOXIN REDUCTASE
(Escherichia
coli) 		5 / 12 ALA A 117
GLY A 213
ALA A  51
LEU A  19
TYR A  52
 None
None
FAD  A 249 (-3.8A)
None
FAD  A 249 (-4.4A)
 1.20A 3rc0B-1fdrA:
undetectable		 3rc0B-1fdrA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 1fdr FLAVODOXIN REDUCTASE
(Escherichia
coli) 		5 / 11 GLY A 213
VAL A 218
GLN A 222
PRO A 120
PHE A  98
 None
 1.28A 4j4vA-1fdrA:
undetectable		 4j4vA-1fdrA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 1fdr FLAVODOXIN REDUCTASE
(Escherichia
coli) 		5 / 11 GLY A 213
VAL A 218
GLN A 222
PRO A 120
PHE A  98
 None
 1.31A 4j4vD-1fdrA:
undetectable
4j4vE-1fdrA:
undetectable		 4j4vD-1fdrA:
21.01
4j4vE-1fdrA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_E_SVRE301_1
(NUCLEOCAPSID PROTEIN)		 1fdr FLAVODOXIN REDUCTASE
(Escherichia
coli) 		5 / 10 GLY A 213
VAL A 218
GLN A 222
PRO A 120
PHE A  98
 None
 1.26A 4j4vA-1fdrA:
undetectable
4j4vE-1fdrA:
undetectable		 4j4vA-1fdrA:
21.01
4j4vE-1fdrA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 1fdr FLAVODOXIN REDUCTASE
(Escherichia
coli) 		5 / 12 LEU A 152
ILE A 168
LEU A 122
LEU A 125
LYS A 160
 None
 1.23A 4l9qB-1fdrA:
undetectable		 4l9qB-1fdrA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_A_ACTA403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1fdr FLAVODOXIN REDUCTASE
(Escherichia
coli) 		3 / 3 VAL A  90
LEU A  39
VAL A  88
 None
 0.62A 4wq4A-1fdrA:
2.5		 4wq4A-1fdrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1fdr FLAVODOXIN REDUCTASE
(Escherichia
coli) 		5 / 9 SER A  53
THR A 116
CYH A 212
GLY A 213
GLU A 245
 FAD  A 249 (-3.7A)
FAD  A 249 (-3.0A)
None
None
FAD  A 249 ( 3.9A)
 0.89A 5vw4A-1fdrA:
21.8		 5vw4A-1fdrA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1fdr FLAVODOXIN REDUCTASE
(Escherichia
coli) 		4 / 4 PRO A 201
MET A 231
GLY A 240
VAL A 209
 None
 1.26A 6ak3A-1fdrA:
0.0		 6ak3A-1fdrA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1fdr FLAVODOXIN REDUCTASE
(Escherichia
coli) 		5 / 11 SER A  53
VAL A 140
LEU A 139
ALA A  33
TYR A 247
 FAD  A 249 (-3.7A)
None
None
None
FAD  A 249 (-3.4A)
 1.28A 6dryA-1fdrA:
undetectable		 6dryA-1fdrA:
22.87