SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1feh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 8 SER A 137
GLY A 194
THR A 356
ILE A 197
None
SF4  A 582 (-3.9A)
None
None
0.80A 1c9sI-1fehA:
undetectable
1c9sJ-1fehA:
undetectable
1c9sI-1fehA:
9.41
1c9sJ-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 8 GLY A 194
THR A 356
ILE A 197
SER A 137
SF4  A 582 (-3.9A)
None
None
None
0.76A 1c9sU-1fehA:
undetectable
1c9sV-1fehA:
undetectable
1c9sU-1fehA:
9.41
1c9sV-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 8 ALA A 307
GLU A 308
ARG A 364
LEU A 477
None
0.94A 1ereE-1fehA:
undetectable
1ereE-1fehA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 8 ALA A 307
GLU A 308
ARG A 364
LEU A 477
None
0.94A 1ereF-1fehA:
undetectable
1ereF-1fehA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 7 GLY A 194
THR A 356
ILE A 197
SER A 137
SF4  A 582 (-3.9A)
None
None
None
0.80A 1gtnA-1fehA:
undetectable
1gtnK-1fehA:
undetectable
1gtnA-1fehA:
9.41
1gtnK-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 8 SER A 137
GLY A 194
THR A 356
ILE A 197
None
SF4  A 582 (-3.9A)
None
None
0.81A 1gtnA-1fehA:
undetectable
1gtnB-1fehA:
0.0
1gtnA-1fehA:
9.41
1gtnB-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 7 SER A 137
GLY A 194
THR A 356
ILE A 197
None
SF4  A 582 (-3.9A)
None
None
0.81A 1gtnC-1fehA:
undetectable
1gtnD-1fehA:
undetectable
1gtnC-1fehA:
9.41
1gtnD-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 6 SER A 137
GLY A 194
THR A 356
ILE A 197
None
SF4  A 582 (-3.9A)
None
None
0.80A 1gtnD-1fehA:
undetectable
1gtnE-1fehA:
undetectable
1gtnD-1fehA:
9.41
1gtnE-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_F_TRPF81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 8 SER A 137
GLY A 194
THR A 356
ILE A 197
None
SF4  A 582 (-3.9A)
None
None
0.80A 1gtnE-1fehA:
undetectable
1gtnF-1fehA:
undetectable
1gtnE-1fehA:
9.41
1gtnF-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_G_TRPG81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 7 SER A 137
GLY A 194
THR A 356
ILE A 197
None
SF4  A 582 (-3.9A)
None
None
0.77A 1gtnF-1fehA:
undetectable
1gtnG-1fehA:
undetectable
1gtnF-1fehA:
9.41
1gtnG-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 7 SER A 137
GLY A 194
THR A 356
ILE A 197
None
SF4  A 582 (-3.9A)
None
None
0.77A 1gtnJ-1fehA:
undetectable
1gtnK-1fehA:
undetectable
1gtnJ-1fehA:
9.41
1gtnK-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 8 GLY A 194
THR A 356
ILE A 197
SER A 137
SF4  A 582 (-3.9A)
None
None
None
0.67A 1gtnP-1fehA:
undetectable
1gtnQ-1fehA:
0.0
1gtnP-1fehA:
9.41
1gtnQ-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
5 / 12 GLY A 421
MET A 497
THR A 275
ILE A 276
PHE A 417
None
HC1  A 580 (-3.3A)
None
None
HC1  A 580 (-4.3A)
1.29A 1p93D-1fehA:
undetectable
1p93D-1fehA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 7 SER A 139
ILE A 198
ILE A 197
THR A 380
None
0.97A 1sbrB-1fehA:
0.0
1sbrB-1fehA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 8 GLY A 194
THR A 356
ILE A 197
SER A 137
SF4  A 582 (-3.9A)
None
None
None
0.79A 1utdI-1fehA:
undetectable
1utdJ-1fehA:
undetectable
1utdI-1fehA:
9.41
1utdJ-1fehA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 8 ASN A  41
GLY A 151
THR A 175
PHE A 168
None
SF4  A 583 (-4.0A)
None
None
1.08A 1ykiA-1fehA:
undetectable
1ykiB-1fehA:
undetectable
1ykiA-1fehA:
17.13
1ykiB-1fehA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 8 ASN A  41
GLY A 151
THR A 175
PHE A 168
None
SF4  A 583 (-4.0A)
None
None
1.07A 1ykiC-1fehA:
undetectable
1ykiD-1fehA:
undetectable
1ykiC-1fehA:
17.13
1ykiD-1fehA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_1
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
3 / 3 GLY A 158
GLU A 162
ASN A 155
None
0.54A 1zq9A-1fehA:
undetectable
1zq9A-1fehA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
3 / 3 THR A 250
PRO A 231
TYR A 410
None
HC1  A 580 (-3.5A)
None
0.93A 2dxrA-1fehA:
undetectable
2dxrA-1fehA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_1
(HYPOTHETICAL PROTEIN
LMO1582)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 4 THR A 163
THR A 188
ASP A 186
ASP A 363
SF4  A 582 (-4.1A)
None
None
None
1.35A 2f8lA-1fehA:
undetectable
2f8lA-1fehA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
3 / 3 ASN A 216
ILE A 379
MET A 387
None
0.85A 2h42C-1fehA:
0.0
2h42C-1fehA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 5 LEU A 140
LEU A 191
CYH A 355
THR A 380
SF4  A 582 ( 4.9A)
SF4  A 582 (-4.3A)
SF4  A 581 ( 2.3A)
None
1.22A 2oaxD-1fehA:
undetectable
2oaxD-1fehA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_3
(PROTEASE RETROPEPSIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
3 / 3 ASP A  25
ASN A  26
THR A  74
None
0.53A 2pymB-1fehA:
0.0
2pymB-1fehA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_4
(PROTEASE RETROPEPSIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
3 / 3 ASP A  25
ASN A  26
THR A  74
None
0.70A 2q63B-1fehA:
undetectable
2q63B-1fehA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 7 VAL A 496
GLY A 473
ALA A 474
LEU A 191
None
None
None
SF4  A 582 (-4.3A)
0.92A 2wekB-1fehA:
2.4
2wekB-1fehA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
5 / 12 THR A 351
ILE A 375
GLY A 271
GLY A 329
PRO A 231
None
None
None
None
HC1  A 580 (-3.5A)
1.04A 2y7hB-1fehA:
undetectable
2y7hB-1fehA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
5 / 12 THR A 351
ILE A 375
GLY A 271
GLY A 329
PRO A 231
None
None
None
None
HC1  A 580 (-3.5A)
1.05A 2y7hC-1fehA:
undetectable
2y7hC-1fehA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAL_A_1GNA998_1
(GALECTIN-7)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 6 ASN A 106
ARG A 103
ASN A 513
GLU A 108
None
1.50A 3galA-1fehA:
undetectable
3galA-1fehA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA315_0
(UNCHARACTERIZED
PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
5 / 11 THR A  60
ILE A  30
THR A  64
VAL A  79
ILE A  83
FES  A 585 ( 4.2A)
None
None
None
None
1.25A 3ijdA-1fehA:
0.0
3ijdA-1fehA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_2
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
3 / 3 ARG A 364
THR A 349
THR A 275
None
0.71A 3k2hB-1fehA:
undetectable
3k2hB-1fehA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
5 / 10 ILE A 268
ASP A 267
ALA A 230
ILE A 198
ILE A 522
HC1  A 580 ( 4.8A)
None
HC1  A 580 (-3.1A)
None
None
1.16A 3prsA-1fehA:
undetectable
3prsA-1fehA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1479_0
(MJ0495-LIKE PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 5 THR A 330
ILE A 327
GLU A 278
PHE A 270
None
1.29A 4ac9C-1fehA:
undetectable
4ac9C-1fehA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 7 GLY A 508
GLY A 507
ASN A 505
GLU A 207
None
0.66A 4fgkB-1fehA:
undetectable
4fgkB-1fehA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 5 GLY A 508
GLY A 507
ASN A 505
GLU A 207
None
0.87A 4fglC-1fehA:
undetectable
4fglC-1fehA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_D_CLQD303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 6 GLY A 508
GLY A 507
ASN A 505
GLU A 207
None
0.75A 4fglD-1fehA:
undetectable
4fglD-1fehA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 8 ASP A 186
CYH A 157
THR A 161
GLY A 194
None
SF4  A 582 (-2.2A)
SF4  A 582 ( 3.9A)
SF4  A 582 (-3.9A)
0.98A 4fo4A-1fehA:
undetectable
4fo4A-1fehA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 5 TYR A 410
LEU A 260
THR A 351
MET A 353
None
None
None
HC1  A 580 (-3.1A)
1.39A 4mbsB-1fehA:
0.0
4mbsB-1fehA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 8 TYR A 552
PHE A 556
GLY A 329
ILE A 226
None
0.77A 4qoiA-1fehA:
0.4
4qoiB-1fehA:
0.4
4qoiA-1fehA:
16.44
4qoiB-1fehA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 7 ALA A 272
GLY A 422
GLU A 425
SER A 430
HC1  A 580 (-3.6A)
None
None
None
0.77A 4r1zB-1fehA:
undetectable
4r1zB-1fehA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 8 SER A 542
ARG A 540
LEU A 537
PHE A 395
None
1.04A 4rkuA-1fehA:
0.0
4rkuJ-1fehA:
0.0
4rkuA-1fehA:
20.69
4rkuJ-1fehA:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
3 / 3 THR A 330
HIS A 543
LEU A 548
None
0.82A 5axdC-1fehA:
undetectable
5axdC-1fehA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
3 / 3 PHE A 241
ILE A 237
ASP A 248
None
0.62A 5cswA-1fehA:
undetectable
5cswA-1fehA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
3 / 3 PHE A 241
ILE A 237
ASP A 248
None
0.68A 5cswB-1fehA:
undetectable
5cswB-1fehA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
3 / 3 LYS A 358
LYS A 322
SER A 323
HC1  A 580 (-2.8A)
None
HC1  A 580 ( 3.8A)
0.93A 5odiA-1fehA:
5.6
5odiA-1fehA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 8 GLY A 178
ARG A 136
VAL A 142
ASP A 134
None
1.00A 5vlmA-1fehA:
0.0
5vlmA-1fehA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
4 / 8 PRO A 510
THR A 380
THR A 381
LYS A 389
None
1.26A 5x2sI-1fehA:
undetectable
5x2sJ-1fehA:
undetectable
5x2sK-1fehA:
undetectable
5x2sI-1fehA:
14.51
5x2sJ-1fehA:
13.63
5x2sK-1fehA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9K_F_ACTF802_0
(UNCHARACTERIZED
PROTEIN)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
3 / 3 TYR A 552
ALA A 331
LEU A 568
None
0.58A 6d9kF-1fehA:
2.9
6d9kF-1fehA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
5 / 8 GLY A 507
VAL A 512
GLY A 418
SER A 232
ALA A 235
None
None
HC1  A 580 ( 3.8A)
HC1  A 580 (-2.8A)
None
1.26A 6hu9H-1fehA:
undetectable
6hu9e-1fehA:
0.7
6hu9H-1fehA:
10.71
6hu9e-1fehA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
1feh PROTEIN (PERIPLASMIC
HYDROGENASE 1)

(Clostridium
pasteurianum)
5 / 8 GLY A 508
VAL A 512
GLY A 418
SER A 232
ALA A 235
None
None
HC1  A 580 ( 3.8A)
HC1  A 580 (-2.8A)
None
1.28A 6hu9H-1fehA:
undetectable
6hu9e-1fehA:
0.7
6hu9H-1fehA:
10.71
6hu9e-1fehA:
12.37