SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fez'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_D_TRPD81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1fez PHOSPHONOACETALDEHYD
E HYDROLASE
(Bacillus
cereus) 		4 / 7 VAL A 202
GLY A 185
THR A  17
THR A  16
 None
 0.80A 1gtnC-1fezA:
undetectable
1gtnD-1fezA:
undetectable		 1gtnC-1fezA:
13.28
1gtnD-1fezA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 1fez PHOSPHONOACETALDEHYD
E HYDROLASE
(Bacillus
cereus) 		5 / 9 GLY A 119
ILE A 112
THR A  16
VAL A   9
ILE A  10
 None
 1.23A 2nnhB-1fezA:
0.0		 2nnhB-1fezA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1fez PHOSPHONOACETALDEHYD
E HYDROLASE
(Bacillus
cereus) 		5 / 8 ALA A 107
GLU A 110
LEU A 252
ILE A 112
VAL A   9
 None
 1.39A 2uxpA-1fezA:
undetectable		 2uxpA-1fezA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 1fez PHOSPHONOACETALDEHYD
E HYDROLASE
(Bacillus
cereus) 		5 / 12 PHE A 237
LEU A 252
ILE A 122
ALA A   8
MET A 191
 None
 1.22A 2v0mC-1fezA:
undetectable		 2v0mC-1fezA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1fez PHOSPHONOACETALDEHYD
E HYDROLASE
(Bacillus
cereus) 		4 / 8 GLY A 203
ASP A  12
GLY A 207
LEU A 206
 None
MG  A 801 (-3.7A)
None
None
 0.52A 3em6A-1fezA:
undetectable		 3em6A-1fezA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 1fez PHOSPHONOACETALDEHYD
E HYDROLASE
(Bacillus
cereus) 		3 / 3 CYH A 166
PRO A 153
ASP A 190
 None
 1.01A 3hlwB-1fezA:
undetectable		 3hlwB-1fezA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 1fez PHOSPHONOACETALDEHYD
E HYDROLASE
(Bacillus
cereus) 		5 / 12 SER A 114
LEU A 115
GLN A 250
ALA A 107
ASP A  12
 None
None
None
None
MG  A 801 (-3.7A)
 1.44A 4j7xA-1fezA:
2.2		 4j7xA-1fezA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1fez PHOSPHONOACETALDEHYD
E HYDROLASE
(Bacillus
cereus) 		3 / 3 PRO A  78
VAL A  57
HIS A  56
 None
 0.84A 4pevC-1fezA:
4.3		 4pevC-1fezA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 1fez PHOSPHONOACETALDEHYD
E HYDROLASE
(Bacillus
cereus) 		3 / 3 CYH A 166
PRO A 153
ASP A 190
 None
 1.02A 4pm5A-1fezA:
undetectable		 4pm5A-1fezA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1fez PHOSPHONOACETALDEHYD
E HYDROLASE
(Bacillus
cereus) 		3 / 3 MET A 165
ASP A  12
PHE A  11
 None
MG  A 801 (-3.7A)
None
 0.98A 4xeyA-1fezA:
undetectable		 4xeyA-1fezA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1fez PHOSPHONOACETALDEHYD
E HYDROLASE
(Bacillus
cereus) 		3 / 3 MET A 165
ASP A  12
PHE A  11
 None
MG  A 801 (-3.7A)
None
 0.92A 4xeyB-1fezA:
undetectable		 4xeyB-1fezA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 1fez PHOSPHONOACETALDEHYD
E HYDROLASE
(Bacillus
cereus) 		5 / 11 THR A 187
PHE A 237
THR A 245
ILE A 246
VAL A 204
 MG  A 801 ( 4.2A)
None
None
None
None
 1.45A 6hcoA-1fezA:
0.0
6hcoB-1fezA:
0.0		 6hcoA-1fezA:
16.92
6hcoB-1fezA:
16.92