SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ff9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		5 / 9 VAL A  72
LEU A  62
ILE A  52
ALA A  32
LEU A   9
 None
 1.18A 1eqgA-1ff9A:
0.0		 1eqgA-1ff9A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		3 / 3 LYS A 408
ILE A  73
THR A 118
 None
 0.75A 1rx3A-1ff9A:
2.3		 1rx3A-1ff9A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_L_DVAL8_0
(7-AMINO-ACTINOMYCIN
D)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		3 / 3 THR A 331
THR A 339
PRO A 332
 None
 0.86A 1unjL-1ff9A:
undetectable		 1unjL-1ff9A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_R_DVAR2_0
(7-AMINO-ACTINOMYCIN
D)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		3 / 3 THR A 339
PRO A 332
THR A 331
 None
 0.87A 1unjR-1ff9A:
undetectable		 1unjR-1ff9A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UNJ_X_DVAX8_0
(7-AMINO-ACTINOMYCIN
D)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		3 / 3 THR A 331
THR A 339
PRO A 332
 None
 0.85A 1unjX-1ff9A:
undetectable		 1unjX-1ff9A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_L_NCTL1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		4 / 7 TYR A 170
CYH A 155
TRP A 174
MET A 395
 None
None
SO4  A 501 (-4.9A)
None
 1.50A 1uw6L-1ff9A:
0.0
1uw6M-1ff9A:
0.0		 1uw6L-1ff9A:
20.05
1uw6M-1ff9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD205_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		5 / 10 ALA A 112
MET A 105
LEU A 108
GLU A 122
SER A  74
 None
SO4  A 503 (-4.1A)
None
None
None
 1.07A 1wrlC-1ff9A:
undetectable
1wrlD-1ff9A:
undetectable		 1wrlC-1ff9A:
10.89
1wrlD-1ff9A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		4 / 7 LEU A 258
PHE A 254
LEU A 344
SER A 326
 None
 0.96A 1wrlE-1ff9A:
0.0
1wrlF-1ff9A:
0.0		 1wrlE-1ff9A:
10.89
1wrlF-1ff9A:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		4 / 8 ASP A 126
THR A 227
PRO A 228
TYR A 233
 None
 0.96A 1z2bB-1ff9A:
undetectable		 1z2bB-1ff9A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		4 / 8 ILE A 123
LEU A 132
ILE A 135
HIS A 131
 None
 0.94A 2azxA-1ff9A:
2.7		 2azxA-1ff9A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		5 / 12 ILE A 442
VAL A 405
ALA A 406
PHE A 409
ILE A 123
 None
 0.88A 2h42C-1ff9A:
0.0		 2h42C-1ff9A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		3 / 3 HIS A  69
ILE A  27
LEU A  19
 None
 0.73A 2kceA-1ff9A:
0.0		 2kceA-1ff9A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		4 / 5 TYR A 233
GLU A 122
ARG A 243
ASP A 417
 None
 1.37A 2yqzA-1ff9A:
6.0		 2yqzA-1ff9A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_1
(HYPOTHETICAL PROTEIN
TTHA0223)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		4 / 5 TYR A 233
GLU A 122
ARG A 243
ASP A 417
 None
 1.36A 2yqzB-1ff9A:
5.6		 2yqzB-1ff9A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		5 / 12 ALA A 187
THR A 206
PHE A 251
ASN A 223
GLY A 244
 None
 1.42A 3aobC-1ff9A:
0.0		 3aobC-1ff9A:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ201_1
(PROTEIN S100-A4)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		4 / 8 PHE A 263
GLY A 262
ILE A 296
PHE A 254
 None
 0.96A 3ko0O-1ff9A:
undetectable
3ko0Q-1ff9A:
undetectable		 3ko0O-1ff9A:
15.38
3ko0Q-1ff9A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		4 / 7 GLU A 140
TYR A 133
GLU A 446
PHE A 364
 None
 1.01A 3ku9B-1ff9A:
4.1		 3ku9B-1ff9A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		5 / 11 PHE A 254
LEU A 258
PHE A 263
LEU A 322
ILE A 324
 None
 1.33A 3o94A-1ff9A:
5.2		 3o94A-1ff9A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		5 / 11 PHE A 254
LEU A 258
PHE A 263
LEU A 322
ILE A 324
 None
 1.35A 3o94C-1ff9A:
5.3		 3o94C-1ff9A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		5 / 11 PHE A 254
LEU A 258
PHE A 263
LEU A 322
ILE A 324
 None
 1.33A 3o94D-1ff9A:
5.4		 3o94D-1ff9A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		6 / 12 VAL A 358
LEU A 436
LEU A 380
VAL A 401
GLY A 400
LEU A 125
 None
 1.46A 3pghC-1ff9A:
undetectable		 3pghC-1ff9A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		5 / 11 ILE A 129
ILE A 123
ILE A 442
ALA A 406
GLU A 435
 None
 0.79A 3tmzA-1ff9A:
0.0		 3tmzA-1ff9A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		5 / 12 TYR A 440
GLY A 400
ILE A 442
ARG A  16
ASP A  20
 None
 0.99A 3uj6A-1ff9A:
4.4		 3uj6A-1ff9A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		4 / 8 ILE A 261
GLY A 262
PHE A 263
SER A 326
 None
 0.89A 4acbB-1ff9A:
5.9
4acbC-1ff9A:
5.9		 4acbB-1ff9A:
24.95
4acbC-1ff9A:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		3 / 3 LYS A 408
ILE A  73
THR A 118
 None
 0.75A 4gh8A-1ff9A:
1.7		 4gh8A-1ff9A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YHA_B_MZMB303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		5 / 10 ASP A  63
HIS A  69
VAL A  66
LEU A   9
ALA A  32
 None
 1.50A 4yhaB-1ff9A:
undetectable		 4yhaB-1ff9A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		4 / 8 LEU A 258
ILE A 300
PHE A 254
GLY A 318
 None
 0.87A 5eseA-1ff9A:
undetectable		 5eseA-1ff9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		5 / 12 TYR A 213
ILE A 135
PHE A 151
VAL A 448
LEU A 360
 None
 1.38A 5esgA-1ff9A:
undetectable		 5esgA-1ff9A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1ff9 SACCHAROPINE
REDUCTASE
(Magnaporthe
grisea) 		3 / 3 LEU A 360
LEU A 125
ARG A 355
 None
 0.59A 5hnzB-1ff9A:
4.5		 5hnzB-1ff9A:
21.95