SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fgg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPK_A_ACAA80_1
(PLASMINOGEN)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		4 / 6 ASP A 196
ASN A 197
ASP A 194
TYR A  84
 MN  A 336 ( 1.8A)
MN  A 336 ( 4.5A)
UDP  A 337 (-3.6A)
UDP  A 337 (-3.7A)
 1.43A 1hpkA-1fggA:
0.0		 1hpkA-1fggA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J7K_A_ACTA701_0
(HOLLIDAY JUNCTION
DNA HELICASE RUVB)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		4 / 4 GLY A 328
LEU A 322
GLY A 326
ARG A 327
 None
 1.31A 1j7kA-1fggA:
2.0		 1j7kA-1fggA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1871_0
(FPRA)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		4 / 7 PHE A 239
PRO A 291
PHE A 249
SER A 282
 None
 1.11A 1lqtA-1fggA:
undetectable		 1lqtA-1fggA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1428_0
(FPRA)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		4 / 7 PHE A 239
PRO A 291
PHE A 249
SER A 282
 None
 1.10A 1lquA-1fggA:
undetectable		 1lquA-1fggA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		5 / 11 LEU A 263
SER A 283
LEU A 284
LEU A 165
ARG A 161
 None
None
None
None
UDP  A 337 ( 4.5A)
 1.06A 2ceoA-1fggA:
0.0		 2ceoA-1fggA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		4 / 7 PHE A 204
LEU A 100
LEU A 130
ARG A 201
 None
 0.99A 2jn3A-1fggA:
undetectable		 2jn3A-1fggA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		4 / 6 HIS A 308
ALA A 254
ALA A 193
THR A  81
 UNX  A 338 ( 3.2A)
None
None
None
 0.93A 2xfhA-1fggA:
0.0		 2xfhA-1fggA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		5 / 10 LEU A 263
SER A 283
LEU A 284
LEU A 165
ARG A 161
 None
None
None
None
UDP  A 337 ( 4.5A)
 1.12A 2xn7A-1fggA:
0.1
2xn7B-1fggA:
0.0		 2xn7A-1fggA:
20.85
2xn7B-1fggA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		4 / 5 PRO A 250
SER A 246
LEU A 285
SER A 286
 None
 1.49A 3ijxH-1fggA:
undetectable		 3ijxH-1fggA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_H_HFZH800_1
(GLUTAMATE RECEPTOR 2)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		4 / 5 PRO A 250
SER A 246
LEU A 285
SER A 286
 None
 1.46A 3iluH-1fggA:
undetectable		 3iluH-1fggA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		4 / 7 MET A 253
ARG A 169
VAL A 213
MET A 207
 None
 1.29A 4f4dA-1fggA:
2.7		 4f4dA-1fggA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_B_ACTB401_0
(UNCHARACTERIZED
PROTEIN)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		4 / 5 VAL A 251
LEU A 294
VAL A 236
PHE A 239
 None
 0.94A 4lb0B-1fggA:
0.1		 4lb0B-1fggA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		3 / 3 ARG A 310
GLU A  92
ARG A 156
 UDP  A 337 (-3.6A)
None
UDP  A 337 (-3.1A)
 0.95A 4mwvA-1fggA:
undetectable		 4mwvA-1fggA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6V_E_RBFE201_1
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT B
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT E)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		4 / 5 HIS A 134
VAL A 111
GLU A 112
VAL A 175
 None
 1.21A 4p6vB-1fggA:
undetectable
4p6vE-1fggA:
0.0		 4p6vB-1fggA:
20.75
4p6vE-1fggA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		4 / 6 ARG A 161
ASP A 194
HIS A 308
ARG A 310
 UDP  A 337 ( 4.5A)
UDP  A 337 (-3.6A)
UNX  A 338 ( 3.2A)
UDP  A 337 (-3.6A)
 1.16A 5a06A-1fggA:
undetectable		 5a06A-1fggA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1fgg GLUCURONYLTRANSFERAS
E I
(Homo
sapiens) 		3 / 3 ASP A 196
ASN A 197
ASP A 252
 MN  A 336 ( 1.8A)
MN  A 336 ( 4.5A)
GAL  A   1 ( 3.5A)
 0.85A 5vopA-1fggA:
3.4		 5vopA-1fggA:
25.08