SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fgv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 1fgv H52 FV (HEAVY CHAIN)
(Homo
sapiens) 		4 / 7 ASP H  62
VAL H  64
GLY H  50
ILE H  51
 ASP  H  62 ( 0.5A)
VAL  H  64 ( 0.6A)
GLY  H  50 ( 0.0A)
ILE  H  51 ( 0.7A)
 0.75A 1t7iB-1fgvH:
undetectable		 1t7iB-1fgvH:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_3
(PHOSPHOLIPASE A2)		 1fgv H52 FV (LIGHT CHAIN)
(Homo
sapiens) 		3 / 3 PRO L   8
PHE L  83
LYS L 103
 PRO  L   8 ( 1.0A)
PHE  L  83 ( 1.3A)
LYS  L 103 ( 0.0A)
 1.25A 3bjwG-1fgvL:
0.0		 3bjwG-1fgvL:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_1
(PROTEASE)		 1fgv H52 FV (HEAVY CHAIN)
(Homo
sapiens) 		4 / 8 ASP H  62
VAL H  64
GLY H  50
ILE H  51
 ASP  H  62 ( 0.5A)
VAL  H  64 ( 0.6A)
GLY  H  50 ( 0.0A)
ILE  H  51 ( 0.7A)
 0.77A 3nu9A-1fgvH:
undetectable		 3nu9A-1fgvH:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1fgv H52 FV (HEAVY CHAIN)
H52 FV (LIGHT CHAIN)
(Homo
sapiens;
Homo
sapiens) 		8 / 12 HIS H  35
GLY H 101
PHE H 111
GLN L  89
GLN L  90
GLY L  91
LEU L  94
PRO L  96
 HIS  H  35 ( 1.0A)
GLY  H 101 ( 0.0A)
PHE  H 111 ( 1.3A)
GLN  L  89 ( 0.6A)
GLN  L  90 ( 0.6A)
GLY  L  91 ( 0.0A)
LEU  L  94 ( 0.6A)
PRO  L  96 ( 1.1A)
 0.85A 4uilH-1fgvH:
20.2
4uilL-1fgvH:
5.2		 4uilH-1fgvH:
53.23
4uilL-1fgvH:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 1fgv H52 FV (HEAVY CHAIN)
H52 FV (LIGHT CHAIN)
(Homo
sapiens;
Homo
sapiens) 		8 / 12 HIS H  35
SER H  59
PHE H 111
GLN L  89
GLN L  90
GLY L  91
LEU L  94
PRO L  96
 HIS  H  35 ( 1.0A)
SER  H  59 ( 0.0A)
PHE  H 111 ( 1.3A)
GLN  L  89 ( 0.6A)
GLN  L  90 ( 0.6A)
GLY  L  91 ( 0.0A)
LEU  L  94 ( 0.6A)
PRO  L  96 ( 1.1A)
 1.00A 4uilH-1fgvH:
20.2
4uilL-1fgvH:
5.2		 4uilH-1fgvH:
53.23
4uilL-1fgvH:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1fgv H52 FV (HEAVY CHAIN)
H52 FV (LIGHT CHAIN)
(Homo
sapiens;
Homo
sapiens) 		6 / 12 HIS H  35
GLY H 101
PHE H 111
GLY L  91
LEU L  94
PRO L  96
 HIS  H  35 ( 1.0A)
GLY  H 101 ( 0.0A)
PHE  H 111 ( 1.3A)
GLY  L  91 ( 0.0A)
LEU  L  94 ( 0.6A)
PRO  L  96 ( 1.1A)
 0.84A 4uinH-1fgvH:
21.2
4uinL-1fgvH:
13.6		 4uinH-1fgvH:
52.42
4uinL-1fgvH:
20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1fgv H52 FV (HEAVY CHAIN)
H52 FV (LIGHT CHAIN)
(Homo
sapiens;
Homo
sapiens) 		6 / 12 HIS H  35
TRP H  47
PHE H 111
GLY L  91
LEU L  94
PRO L  96
 HIS  H  35 ( 1.0A)
TRP  H  47 ( 0.4A)
PHE  H 111 ( 1.3A)
GLY  L  91 ( 0.0A)
LEU  L  94 ( 0.6A)
PRO  L  96 ( 1.1A)
 0.73A 4uinH-1fgvH:
21.2
4uinL-1fgvH:
13.6		 4uinH-1fgvH:
52.42
4uinL-1fgvH:
20.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1fgv H52 FV (HEAVY CHAIN)
H52 FV (LIGHT CHAIN)
(Homo
sapiens;
Homo
sapiens) 		6 / 12 TRP H  47
SER H  59
PHE H 111
GLY L  91
LEU L  94
PRO L  96
 TRP  H  47 ( 0.4A)
SER  H  59 ( 0.0A)
PHE  H 111 ( 1.3A)
GLY  L  91 ( 0.0A)
LEU  L  94 ( 0.6A)
PRO  L  96 ( 1.1A)
 0.91A 4uinH-1fgvH:
21.2
4uinL-1fgvH:
13.6		 4uinH-1fgvH:
52.42
4uinL-1fgvH:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 1fgv H52 FV (HEAVY CHAIN)
(Homo
sapiens) 		5 / 9 ARG H  38
ALA H  88
VAL H 122
SER H 123
ASP H  90
 ARG  H  38 ( 0.7A)
ALA  H  88 ( 0.0A)
VAL  H 122 ( 0.6A)
SER  H 123 ( 0.0A)
ASP  H  90 ( 0.6A)
 1.43A 6c2mA-1fgvH:
undetectable		 6c2mA-1fgvH:
23.53