SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fh0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 1fh0 CATHEPSIN V
(Homo
sapiens) 		3 / 3 ALA A  33
VAL A 168
TRP A   7
 None
 1.00A 1c4dA-1fh0A:
undetectable
1c4dB-1fh0A:
undetectable		 1c4dA-1fh0A:
6.28
1c4dB-1fh0A:
6.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1fh0 CATHEPSIN V
(Homo
sapiens) 		7 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 163
 0IW  A1280 (-2.9A)
0IW  A1280 (-3.6A)
None
0IW  A1280 (-4.9A)
None
None
0IW  A1280 (-4.0A)
 0.33A 1stfE-1fh0A:
33.9
1stfI-1fh0A:
0.8		 1stfE-1fh0A:
43.11
1stfI-1fh0A:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 1fh0 CATHEPSIN V
(Homo
sapiens) 		4 / 7 THR A  14
PRO A  15
VAL A  16
GLU A  50
 None
 1.06A 2v2gA-1fh0A:
undetectable
2v2gB-1fh0A:
undetectable		 2v2gA-1fh0A:
21.92
2v2gB-1fh0A:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1fh0 CATHEPSIN V
(Homo
sapiens) 		4 / 7 GLN A  19
GLY A  23
HIS A 163
TRP A 189
 0IW  A1280 (-2.9A)
0IW  A1280 (-3.6A)
0IW  A1280 (-4.0A)
0IW  A1280 (-4.0A)
 0.43A 3ai8A-1fh0A:
17.3		 3ai8A-1fh0A:
31.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1fh0 CATHEPSIN V
(Homo
sapiens) 		3 / 3 ASN A 187
ASN A  18
GLU A 192
 None
 0.75A 3kpdC-1fh0A:
0.0		 3kpdC-1fh0A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1fh0 CATHEPSIN V
(Homo
sapiens) 		3 / 3 ASN A 187
ASN A  18
GLU A 192
 None
 0.78A 3kpdB-1fh0A:
0.0		 3kpdB-1fh0A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 1fh0 CATHEPSIN V
(Homo
sapiens) 		5 / 9 VAL A 115
VAL A 114
VAL A 129
ILE A 132
ALA A 212
 None
 1.18A 4fwdA-1fh0A:
0.2		 4fwdA-1fh0A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1fh0 CATHEPSIN V
(Homo
sapiens) 		5 / 11 ILE A 211
LYS A 205
SER A 142
ILE A 201
THR A 213
 None
 1.46A 4p68A-1fh0A:
undetectable		 4p68A-1fh0A:
20.00