SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fhe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 1fhe GLUTATHIONE
TRANSFERASE
(Fasciola
hepatica) 		4 / 7 TYR A   6
GLY A  11
TYR A 110
GLY A 204
 None
 0.73A 11gsB-1fheA:
24.7		 11gsB-1fheA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1fhe GLUTATHIONE
TRANSFERASE
(Fasciola
hepatica) 		4 / 7 ILE A  70
PRO A  55
ARG A  17
ALA A  13
 None
 1.11A 1oniG-1fheA:
undetectable
1oniI-1fheA:
undetectable		 1oniG-1fheA:
20.67
1oniI-1fheA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1fhe GLUTATHIONE
TRANSFERASE
(Fasciola
hepatica) 		3 / 3 LEU A 185
TYR A  22
GLY A  24
 None
 0.51A 2ocuA-1fheA:
undetectable		 2ocuA-1fheA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 1fhe GLUTATHIONE
TRANSFERASE
(Fasciola
hepatica) 		4 / 8 TYR A   6
GLY A  11
TYR A 110
GLY A 204
 None
 0.69A 3n9jB-1fheA:
24.6		 3n9jB-1fheA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DV1_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 1fhe GLUTATHIONE
TRANSFERASE
(Fasciola
hepatica) 		3 / 3 LYS A 130
LYS A 127
PRO A 126
 None
 1.16A 4dv1L-1fheA:
0.0		 4dv1L-1fheA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 1fhe GLUTATHIONE
TRANSFERASE
(Fasciola
hepatica) 		4 / 6 GLY A  33
GLY A   5
GLU A  29
TYR A   6
 None
 0.79A 4dxuA-1fheA:
undetectable		 4dxuA-1fheA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1fhe GLUTATHIONE
TRANSFERASE
(Fasciola
hepatica) 		6 / 12 LEU A 136
PHE A 178
ILE A  94
GLY A 144
ILE A 182
VAL A 150
 None
 1.31A 4nkxA-1fheA:
undetectable		 4nkxA-1fheA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_B_STRB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1fhe GLUTATHIONE
TRANSFERASE
(Fasciola
hepatica) 		6 / 12 LEU A 136
PHE A 178
ILE A  94
GLY A 144
ILE A 182
VAL A 150
 None
 1.31A 4nkxB-1fheA:
0.0		 4nkxB-1fheA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1fhe GLUTATHIONE
TRANSFERASE
(Fasciola
hepatica) 		4 / 7 THR A 157
LEU A 158
LEU A 154
THR A 128
 None
 0.90A 4z90A-1fheA:
2.0
4z90B-1fheA:
2.0
4z90C-1fheA:
2.4
4z90D-1fheA:
2.3
4z90E-1fheA:
2.3		 4z90A-1fheA:
21.32
4z90B-1fheA:
21.32
4z90C-1fheA:
21.32
4z90D-1fheA:
21.32
4z90E-1fheA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1fhe GLUTATHIONE
TRANSFERASE
(Fasciola
hepatica) 		5 / 7 GLY A  79
LEU A  81
LEU A 142
LEU A  23
ILE A 182
 None
 1.31A 5vkqA-1fheA:
0.0
5vkqB-1fheA:
0.0		 5vkqA-1fheA:
8.46
5vkqB-1fheA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 1fhe GLUTATHIONE
TRANSFERASE
(Fasciola
hepatica) 		5 / 12 ALA A  97
GLY A  96
LEU A 154
VAL A 150
LEU A 129
 None
 1.12A 5w7pA-1fheA:
0.0		 5w7pA-1fheA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1fhe GLUTATHIONE
TRANSFERASE
(Fasciola
hepatica) 		4 / 4 GLY A 204
ARG A 102
ASN A 203
LEU A   9
 None
 1.24A 6b58A-1fheA:
0.0		 6b58A-1fheA:
16.12