SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fht'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VIF_A_FOLA1_0
(DIHYDROFOLATE
REDUCTASE)		 1fht U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A
(Homo
sapiens) 		3 / 3 GLN A  53
ILE A  13
TYR A  12
 None
 0.68A 1vifA-1fhtA:
0.0		 1vifA-1fhtA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1fht U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A
(Homo
sapiens) 		5 / 12 ASP A  89
ALA A  54
ILE A  83
ALA A  64
PHE A  58
 None
 1.13A 2ejtA-1fhtA:
undetectable		 2ejtA-1fhtA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 1fht U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A
(Homo
sapiens) 		4 / 8 SER A  70
ALA A  64
PHE A  33
ILE A  39
 None
 0.98A 3bpxA-1fhtA:
0.0
3bpxB-1fhtA:
0.0		 3bpxA-1fhtA:
22.88
3bpxB-1fhtA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1fht U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A
(Homo
sapiens) 		3 / 3 GLY A  37
ILE A  57
VAL A  56
 None
 0.50A 3nv6A-1fhtA:
0.0		 3nv6A-1fhtA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1fht U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A
(Homo
sapiens) 		4 / 7 GLU A  24
TYR A  77
LEU A  16
ARG A  46
 None
 1.15A 4twdF-1fhtA:
undetectable
4twdJ-1fhtA:
undetectable		 4twdF-1fhtA:
16.61
4twdJ-1fhtA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1fht U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN A
(Homo
sapiens) 		4 / 6 ARG A  46
GLU A  24
TYR A  77
LEU A  16
 None
 1.09A 4twdF-1fhtA:
undetectable
4twdG-1fhtA:
undetectable		 4twdF-1fhtA:
16.61
4twdG-1fhtA:
16.61