SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fi4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 SER A 146
ALA A 156
SER A 178
ALA A 180
 None
 1.05A 1k5qA-1fi4A:
0.0
1k5qB-1fi4A:
0.1		 1k5qA-1fi4A:
19.66
1k5qB-1fi4A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 4 SER A 146
VAL A 129
PHE A 161
VAL A 165
 None
 1.39A 1o86A-1fi4A:
0.3		 1o86A-1fi4A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 376
GLY A 163
LEU A  39
ASP A  43
SER A 187
 None
 1.18A 1xdsA-1fi4A:
undetectable		 1xdsA-1fi4A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 GLU A  88
SER A 100
GLN A 101
ASP A  81
 None
 1.22A 2cl5B-1fi4A:
0.0		 2cl5B-1fi4A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F6D_A_ACRA996_1
(GLUCOAMYLASE GLU1)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 HIS A 105
ASN A  64
THR A 391
GLY A 392
 None
 1.02A 2f6dA-1fi4A:
0.0		 2f6dA-1fi4A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 6 GLU A  88
SER A 100
GLN A 101
ASP A  81
 None
 1.22A 2zvjA-1fi4A:
0.5		 2zvjA-1fi4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_B_T44B128_1
(TRANSTHYRETIN)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 ALA A  51
SER A   7
THR A   5
VAL A   3
 None
 0.49A 3ozkB-1fi4A:
0.0		 3ozkB-1fi4A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 ASP A  42
GLU A 384
THR A 382
SER A 186
 None
 1.35A 3p2kC-1fi4A:
undetectable		 3p2kC-1fi4A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 118
VAL A  12
VAL A 196
ASP A  43
 None
 0.85A 3rgfA-1fi4A:
0.0		 3rgfA-1fi4A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 260
CYH A 264
HIS A 261
 None
 0.82A 3u9fF-1fi4A:
0.6		 3u9fF-1fi4A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 260
CYH A 264
HIS A 261
 None
 0.90A 3u9fG-1fi4A:
undetectable		 3u9fG-1fi4A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 260
CYH A 264
HIS A 261
 None
 0.87A 3u9fL-1fi4A:
0.0		 3u9fL-1fi4A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A 260
CYH A 264
HIS A 261
 None
 0.97A 3u9fS-1fi4A:
0.0		 3u9fS-1fi4A:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR2_A_PARA1609_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 TYR A 136
ARG A  83
SER A 100
 None
 1.11A 4dr2I-1fi4A:
3.8
4dr2J-1fi4A:
1.6		 4dr2I-1fi4A:
14.66
4dr2J-1fi4A:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 8 ALA A  51
SER A   7
THR A   5
VAL A   3
 None
 0.54A 4ik7B-1fi4A:
0.0		 4ik7B-1fi4A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QN9_B_DXCB610_0
(N-ACYL-PHOSPHATIDYLE
THANOLAMINE-HYDROLYZ
ING PHOSPHOLIPASE D)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 378
PRO A 379
ALA A 127
 None
 0.43A 4qn9B-1fi4A:
undetectable		 4qn9B-1fi4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 SER A  33
ALA A 166
VAL A 165
 None
 0.52A 4x20C-1fi4A:
undetectable		 4x20C-1fi4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 9 SER A 120
ALA A 123
LEU A  44
ILE A  14
 None
 0.87A 4xtaA-1fi4A:
undetectable		 4xtaA-1fi4A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 GLU A  88
SER A 100
GLN A 101
ASP A  81
 None
 1.22A 5fhrB-1fi4A:
undetectable		 5fhrB-1fi4A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 12 ALA A 166
GLN A 380
GLY A 162
SER A 377
SER A  36
 None
 1.22A 5hfjB-1fi4A:
undetectable		 5hfjB-1fi4A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		5 / 11 TYR A 136
ARG A  83
ILE A 145
PHE A 125
LEU A 128
 None
 1.45A 5huaA-1fi4A:
undetectable		 5huaA-1fi4A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		3 / 3 ASN A  28
TYR A  19
CYH A 157
 None
 0.65A 5lsuB-1fi4A:
undetectable		 5lsuB-1fi4A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 273
VAL A  12
MET A 212
GLY A 211
 None
 1.03A 6hd4A-1fi4A:
undetectable		 6hd4A-1fi4A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_A_STIA604_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 273
VAL A  37
MET A 212
GLY A 211
 None
 1.43A 6hd4A-1fi4A:
undetectable		 6hd4A-1fi4A:
14.16