SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fi8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		5 / 8 HIS A  57
SER A 190
SER A 195
VAL A 213
GLY A 216
 None
 0.51A 1aq7A-1fi8A:
35.9		 1aq7A-1fi8A:
38.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		4 / 8 PHE A 228
THR A 229
ASP A 102
HIS A  57
 None
 0.84A 1ei6C-1fi8A:
undetectable		 1ei6C-1fi8A:
19.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		4 / 8 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
 0.41A 1f5lA-1fi8A:
10.5		 1f5lA-1fi8A:
32.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		4 / 6 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
 0.33A 1tnlA-1fi8A:
36.0		 1tnlA-1fi8A:
38.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_C_ADNC2502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		5 / 12 LEU A 160
THR A 224
ASP A 194
GLY A 220
PHE A 228
 None
 1.20A 1v8bC-1fi8A:
undetectable		 1v8bC-1fi8A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_D_ADND3502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		5 / 12 LEU A 160
THR A 224
ASP A 194
GLY A 220
PHE A 228
 None
 1.22A 1v8bD-1fi8A:
undetectable		 1v8bD-1fi8A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_1
(THYMIDYLATE SYNTHASE)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		5 / 12 SER A  26
LEU A 199
ASP A 194
GLY A 140
ALA A 189
 None
 1.07A 2kceA-1fi8A:
0.0		 2kceA-1fi8A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_B_D16B568_1
(THYMIDYLATE SYNTHASE)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		5 / 12 SER A  26
LEU A 199
ASP A 194
GLY A 140
ALA A 189
 None
 1.12A 2kceB-1fi8A:
undetectable		 2kceB-1fi8A:
18.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		4 / 6 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
 0.39A 2otvA-1fi8A:
36.1		 2otvA-1fi8A:
38.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
LEU A  53
 None
 1.44A 2oxtD-1fi8A:
undetectable		 2oxtD-1fi8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		4 / 5 LEU A 123
PRO A 124
LEU A 235
ILE A 238
 None
 0.86A 2qd4A-1fi8A:
undetectable		 2qd4A-1fi8A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		5 / 12 VAL A 213
ASP A 194
GLY A 142
ALA A 183
PHE A 228
 None
 0.90A 2v0zO-1fi8A:
undetectable		 2v0zO-1fi8A:
20.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		4 / 8 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
 0.31A 2vinA-1fi8A:
9.3		 2vinA-1fi8A:
32.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_A_MIYA2001_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		4 / 8 GLY A  44
ILE A 212
ALA A  55
PHE A 228
 None
 0.92A 3aodA-1fi8A:
0.0		 3aodA-1fi8A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		3 / 3 GLY A 197
GLY A 193
GLY A  43
 None
 0.29A 3bogC-1fi8A:
0.0		 3bogC-1fi8A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		4 / 5 TYR A 137
ALA A 183
ALA A 209
MET A  30
 None
 0.84A 3d91A-1fi8A:
0.0		 3d91A-1fi8A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		5 / 12 LEU A 106
GLY A  43
GLY A  44
SER A 190
ASP A 102
 None
 1.18A 3i5uB-1fi8A:
undetectable		 3i5uB-1fi8A:
20.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		4 / 6 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
 0.41A 3rxfA-1fi8A:
13.4		 3rxfA-1fi8A:
38.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 1fi8 ECOTIN
ECOTIN
(Escherichia
coli;
Escherichia
coli) 		4 / 4 LEU D 101
GLY D 105
LEU C  40
GLU C  39
 None
 1.03A 3tgvB-1fi8D:
undetectable		 3tgvB-1fi8D:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		3 / 3 PRO A 185
THR A 224
LEU A 160
 None
 0.80A 3ttrA-1fi8A:
undetectable		 3ttrA-1fi8A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 1fi8 ECOTIN
ECOTIN
(Escherichia
coli;
Escherichia
coli) 		5 / 8 GLY C  57
GLY C  56
GLY C  43
LEU C  46
VAL D 123
 None
 1.18A 3v1nA-1fi8C:
undetectable		 3v1nA-1fi8C:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		4 / 4 LEU A 123
PRO A 124
LEU A 235
ILE A 238
 None
 0.95A 4f4dB-1fi8A:
undetectable		 4f4dB-1fi8A:
20.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		4 / 5 HIS A  57
TYR A 151
GLY A 193
SER A 195
 None
 0.68A 4fu8A-1fi8A:
10.6		 4fu8A-1fi8A:
32.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 1fi8 ECOTIN
(Escherichia
coli) 		3 / 3 TYR D 127
GLN C  30
TRP D 130
 None
 1.12A 4kn2C-1fi8D:
undetectable		 4kn2C-1fi8D:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 1fi8 ECOTIN
NATURAL KILLER CELL
PROTEASE 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 11 ASP C  84
VAL A 138
GLY A 142
SER A 195
GLY A 197
 None
 1.14A 4mm9A-1fi8C:
undetectable		 4mm9A-1fi8C:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 1fi8 ECOTIN
NATURAL KILLER CELL
PROTEASE 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 9 ASP C  84
VAL A 138
GLY A 142
SER A 195
GLY A 197
 None
 1.04A 4mmbA-1fi8C:
undetectable		 4mmbA-1fi8C:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 1fi8 ECOTIN
NATURAL KILLER CELL
PROTEASE 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 10 ASP C  84
VAL A 138
GLY A 142
SER A 195
GLY A 197
 None
 1.04A 4mmcA-1fi8C:
undetectable		 4mmcA-1fi8C:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 1fi8 ECOTIN
NATURAL KILLER CELL
PROTEASE 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 12 ASP C  84
VAL A 138
GLY A 142
SER A 195
GLY A 197
 None
 1.17A 4mmdB-1fi8C:
undetectable		 4mmdB-1fi8C:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_A_29QA603_1
(TRANSPORTER)		 1fi8 ECOTIN
NATURAL KILLER CELL
PROTEASE 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 9 ASP C  84
VAL A 138
GLY A 142
SER A 195
GLY A 197
 None
 1.12A 4mmeA-1fi8C:
undetectable		 4mmeA-1fi8C:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MME_B_29QB603_1
(TRANSPORTER)		 1fi8 ECOTIN
NATURAL KILLER CELL
PROTEASE 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 9 ASP C  84
VAL A 138
GLY A 142
SER A 195
GLY A 197
 None
 1.11A 4mmeB-1fi8C:
undetectable		 4mmeB-1fi8C:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 1fi8 ECOTIN
NATURAL KILLER CELL
PROTEASE 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 9 ASP C  84
VAL A 138
GLY A 142
SER A 195
GLY A 197
 None
 1.19A 4mmfA-1fi8C:
undetectable		 4mmfA-1fi8C:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 1fi8 ECOTIN
NATURAL KILLER CELL
PROTEASE 1
(Escherichia
coli;
Rattus
norvegicus) 		5 / 9 ASP C  84
VAL A 138
GLY A 142
SER A 195
GLY A 197
 None
 1.14A 4mmfB-1fi8C:
undetectable		 4mmfB-1fi8C:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
(Rattus
norvegicus) 		5 / 12 VAL A 231
GLY A  44
ILE A 103
LEU A 105
LEU A  46
 None
 0.95A 4qdjA-1fi8A:
undetectable		 4qdjA-1fi8A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 1fi8 ECOTIN
(Escherichia
coli) 		4 / 7 GLY C  57
GLY C  56
ALA D  99
ILE C  81
 None
 0.71A 4yjiA-1fi8C:
undetectable		 4yjiA-1fi8C:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 1fi8 NATURAL KILLER CELL
PROTEASE 1
ECOTIN
(Rattus
norvegicus;
Escherichia
coli) 		4 / 8 ASN A 179
GLU A 169
PHE A 175
TYR D 100
 None
 1.22A 5oh1C-1fi8A:
undetectable		 5oh1C-1fi8A:
19.37