SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fim'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 1fim MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Rattus
norvegicus) 		4 / 6 ARG A  93
THR A   7
ALA A  57
PRO A  10
 None
 1.34A 2ql8A-1fimA:
2.1
2ql8B-1fimA:
undetectable		 2ql8A-1fimA:
18.31
2ql8B-1fimA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLB_D_TMQD614_1
(DHFR-TS)		 1fim MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Rattus
norvegicus) 		5 / 10 VAL A  94
ILE A   4
PRO A   1
ILE A  96
THR A   7
 None
 1.25A 3clbD-1fimA:
3.1		 3clbD-1fimA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_D_TMQD614_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1fim MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Rattus
norvegicus) 		5 / 10 VAL A  94
ILE A   4
PRO A   1
ILE A  96
THR A   7
 None
 1.26A 3hbbD-1fimA:
3.3		 3hbbD-1fimA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HM1_A_J3ZA2_1
(ESTROGEN RECEPTOR)		 1fim MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Rattus
norvegicus) 		5 / 12 THR A  30
ALA A  29
LEU A  79
LEU A  78
LEU A  61
 None
 1.17A 3hm1A-1fimA:
undetectable		 3hm1A-1fimA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1fim MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Rattus
norvegicus) 		5 / 12 LEU A  78
SER A  84
PHE A   3
ALA A  57
PHE A  18
 None
 1.34A 4nc3A-1fimA:
undetectable		 4nc3A-1fimA:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1fim MACROPHAGE MIGRATION
INHIBITORY FACTOR
(Rattus
norvegicus) 		5 / 12 LEU A  78
SER A  84
PHE A   3
ALA A  57
PHE A  18
 None
 1.29A 6drxA-1fimA:
undetectable		 6drxA-1fimA:
13.51