SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fio'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 1fio SSO1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 9 LEU A 213
LEU A  94
ILE A  98
LEU A 123
ILE A 126
 None
 1.27A 2f7aA-1fioA:
undetectable		 2f7aA-1fioA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 1fio SSO1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 106
GLY A 105
ALA A 113
ASP A 108
ALA A 101
 None
 1.01A 3jb1A-1fioA:
0.0		 3jb1A-1fioA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1fio SSO1 PROTEIN
(Saccharomyces
cerevisiae) 		4 / 8 ASN A  69
LEU A  64
HIS A  75
ARG A  77
 None
None
ZN  A 502 (-3.2A)
None
 1.06A 3kp2A-1fioA:
2.0
3kp2B-1fioA:
1.6		 3kp2A-1fioA:
26.94
3kp2B-1fioA:
26.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_1
(MEDI2452 HEAVY CHAIN
MEDI2452 LIGHT CHAIN)		 1fio SSO1 PROTEIN
(Saccharomyces
cerevisiae) 		5 / 11 HIS A  61
ILE A  54
THR A  53
TYR A 129
ASP A 133
 None
 1.44A 5albH-1fioA:
undetectable		 5albH-1fioA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1fio SSO1 PROTEIN
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 133
ASN A 140
PHE A  83
 None
 0.81A 5jglB-1fioA:
undetectable		 5jglB-1fioA:
20.62