SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fiu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		3 / 3 ASP A 140
PHE A  69
VAL A 219
 MG  A5555 (-2.6A)
None
None
 0.75A 1kijB-1fiuA:
0.0		 1kijB-1fiuA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 205
VAL A 217
HIS A 215
LEU A 284
HIS A 181
 None
 1.46A 1rk3A-1fiuA:
0.0		 1rk3A-1fiuA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		3 / 3 ARG A 191
ARG A 194
ILE A 231
 None
 0.76A 1uobA-1fiuA:
0.0		 1uobA-1fiuA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		5 / 12 HIS A  13
ASP A 276
LEU A 246
ILE A  47
SER A  40
 None
 1.44A 1xomA-1fiuA:
undetectable		 1xomA-1fiuA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		5 / 12 HIS A  13
ASP A 276
LEU A 246
ILE A  47
SER A  40
 None
 1.43A 1xoqA-1fiuA:
undetectable		 1xoqA-1fiuA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		5 / 12 HIS A  13
ASP A 276
LEU A 246
ILE A  47
SER A  40
 None
 1.44A 1xoqB-1fiuA:
undetectable		 1xoqB-1fiuA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX94_0
(PROTEIN S100-B)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		3 / 3 PHE A  69
CYH A  73
PHE A  12
 None
 1.06A 3cr5X-1fiuA:
0.0		 3cr5X-1fiuA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		5 / 12 HIS A  13
ASP A 276
LEU A 246
ILE A  47
SER A  40
 None
 1.47A 3g4lD-1fiuA:
undetectable		 3g4lD-1fiuA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		3 / 3 PRO A 178
LEU A 179
GLN A 109
 None
 0.69A 3hznG-1fiuA:
0.6
3hznH-1fiuA:
0.0		 3hznG-1fiuA:
20.34
3hznH-1fiuA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP2_A_PNNA5001_0
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		4 / 8 ASN A 146
THR A 144
LEU A 180
GLN A 110
 None
 1.04A 3kp2A-1fiuA:
0.0
3kp2B-1fiuA:
0.0		 3kp2A-1fiuA:
22.06
3kp2B-1fiuA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		4 / 8 ASN A 146
THR A 144
LEU A 180
GLN A 110
 None
 0.97A 3kp6A-1fiuA:
0.0		 3kp6A-1fiuA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 205
VAL A 217
HIS A 215
LEU A 284
HIS A 181
 None
 1.46A 3vt3A-1fiuA:
0.2		 3vt3A-1fiuA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT7_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		5 / 12 LEU A 205
VAL A 217
HIS A 215
LEU A 284
HIS A 181
 None
 1.47A 3vt7A-1fiuA:
0.0		 3vt7A-1fiuA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JLT_A_8PRA505_1
(CYTOCHROME P450 2B4)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		4 / 8 ILE A  47
ALA A 245
PRO A 225
VAL A 269
 None
 0.80A 4jltA-1fiuA:
undetectable		 4jltA-1fiuA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLM_A_198A1001_2
(ANDROGEN RECEPTOR)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		4 / 6 ASN A 197
ILE A 238
ILE A 231
VAL A 241
 ACY  A2001 (-3.6A)
None
None
None
 0.95A 4olmA-1fiuA:
0.0		 4olmA-1fiuA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		5 / 10 ILE A 153
ILE A 148
LEU A 147
ILE A 164
ASN A 163
 None
 1.09A 5vkqA-1fiuA:
0.0
5vkqD-1fiuA:
0.0		 5vkqA-1fiuA:
10.70
5vkqD-1fiuA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		5 / 10 ILE A 164
ASN A 163
ILE A 153
ILE A 148
LEU A 147
 None
 1.07A 5vkqA-1fiuA:
0.0
5vkqB-1fiuA:
0.0		 5vkqA-1fiuA:
10.70
5vkqB-1fiuA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		4 / 9 ILE A 164
ILE A 153
ILE A 148
LEU A 147
 None
 0.78A 5vkqB-1fiuA:
0.0
5vkqC-1fiuA:
0.1		 5vkqB-1fiuA:
10.70
5vkqC-1fiuA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		5 / 10 ILE A 164
ASN A 163
ILE A 153
ILE A 148
LEU A 147
 None
 1.09A 5vkqC-1fiuA:
0.1
5vkqD-1fiuA:
0.0		 5vkqC-1fiuA:
10.70
5vkqD-1fiuA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW2_A_ACTA511_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		3 / 3 ARG A 227
ILE A 190
SER A 192
 None
 0.88A 5zw2A-1fiuA:
0.0		 5zw2A-1fiuA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E43_D_BEZD502_0
(INDOLEAMINE
2,3-DIOXYGENASE 1)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		4 / 6 LEU A 170
LEU A 179
ARG A 145
HIS A 181
 None
 0.91A 6e43D-1fiuA:
0.0		 6e43D-1fiuA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)		 1fiu TYPE II RESTRICTION
ENZYME NGOMI
(Neisseria
gonorrhoeae) 		3 / 3 ASP A 193
ASP A  34
ASN A  25
 None
 0.77A 6gngB-1fiuA:
undetectable		 6gngB-1fiuA:
18.66