SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fiw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		6 / 8 HIS A  57
ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
 None
PBZ  A 305 (-2.7A)
PBZ  A 305 (-3.2A)
PBZ  A 305 (-2.9A)
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
 0.90A 1aq7A-1fiwA:
34.4		 1aq7A-1fiwA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		5 / 9 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
 0.38A 1bcuH-1fiwA:
35.4		 1bcuH-1fiwA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
 None
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.3A)
 0.47A 1dwcH-1fiwA:
34.8		 1dwcH-1fiwA:
31.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		6 / 12 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
 0.60A 1etrH-1fiwA:
34.7		 1etrH-1fiwA:
34.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		4 / 8 ASP A 189
SER A 195
GLY A 216
GLY A 226
 PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
 0.30A 1f5lA-1fiwA:
36.6		 1f5lA-1fiwA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		4 / 7 GLU A 157
LEU A 155
MET A  30
MET A 200
 None
 1.02A 1linA-1fiwA:
undetectable		 1linA-1fiwA:
17.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
 PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
 0.35A 1tnlA-1fiwA:
16.2		 1tnlA-1fiwA:
34.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		5 / 10 THR A 190
GLY A 140
GLY A 142
ILE A 188
ALA A 158
 PBZ  A 305 (-3.9A)
None
None
None
None
 1.10A 1x7pA-1fiwA:
undetectable
1x7pB-1fiwA:
undetectable		 1x7pA-1fiwA:
23.03
1x7pB-1fiwA:
23.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
 PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
 0.23A 2otvA-1fiwA:
16.4		 2otvA-1fiwA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		6 / 12 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
 PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
None
 0.30A 2p16A-1fiwA:
35.3		 2p16A-1fiwA:
31.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		4 / 8 ASP A 189
SER A 195
GLY A 216
GLY A 226
 PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
 0.34A 2vinA-1fiwA:
37.1		 2vinA-1fiwA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		7 / 12 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
 PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-4.9A)
PBZ  A 305 (-3.3A)
None
 0.34A 2w26A-1fiwA:
35.4		 2w26A-1fiwA:
31.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		3 / 3 GLY A 197
GLY A 193
GLY A  43
 None
 0.34A 3bogC-1fiwA:
undetectable		 3bogC-1fiwA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		5 / 12 LEU A  53
LEU A  47
GLN A  50
ILE A 238
ALA A 246
 None
 1.08A 3gwwA-1fiwA:
undetectable		 3gwwA-1fiwA:
18.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		6 / 11 ASP A 189
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
 PBZ  A 305 (-2.7A)
PBZ  A 305 (-3.2A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
 0.81A 3gy3A-1fiwA:
16.4		 3gy3A-1fiwA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		6 / 11 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
 None
PBZ  A 305 (-2.7A)
PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
 0.37A 3gy3A-1fiwA:
16.4		 3gy3A-1fiwA:
34.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		4 / 6 SER A 195
TRP A 215
GLY A 216
GLY A 226
 PBZ  A 305 (-2.9A)
None
PBZ  A 305 (-3.4A)
PBZ  A 305 (-3.3A)
 0.28A 3rxfA-1fiwA:
16.9		 3rxfA-1fiwA:
34.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		4 / 6 ILE A 118
VAL A  31
LEU A  33
ILE A  65
 None
 0.89A 4asdA-1fiwA:
undetectable		 4asdA-1fiwA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		4 / 4 LEU A 123
PRO A 124
LEU A 235
ILE A 238
 None
 0.92A 4f4dB-1fiwA:
undetectable		 4f4dB-1fiwA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		3 / 3 ASP A 102
TRP A  63
SER A 195
 None
None
PBZ  A 305 (-2.9A)
 1.06A 4lrhB-1fiwA:
undetectable		 4lrhB-1fiwA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		4 / 7 HIS A  91
ARG A  60
ILE A  90
ALA A  56
 None
 0.85A 4lv9A-1fiwA:
undetectable		 4lv9A-1fiwA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTS_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 1fiw BETA-ACROSIN HEAVY
CHAIN
BETA-ACROSIN LIGHT
CHAIN
(Ovis
aries;
Ovis
aries) 		5 / 12 GLY L   7
GLY L  10
ASN A 202
SER A 202
PRO A 253
 None
 1.22A 4rtsA-1fiwL:
undetectable		 4rtsA-1fiwL:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_B_ADNB301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		5 / 9 PRO A 198
LEU A  33
ILE A 212
LEU A  53
THR A  54
 None
 1.22A 4x3mB-1fiwA:
undetectable		 4x3mB-1fiwA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_A_SAMA301_0
(PANTOTHENATE
SYNTHETASE)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		5 / 12 GLY A 211
VAL A 112
GLY A 196
THR A 213
LEU A 199
 None
 1.06A 5hg0A-1fiwA:
undetectable		 5hg0A-1fiwA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		5 / 12 GLY A 211
VAL A 112
GLY A 196
THR A 213
LEU A 199
 None
 1.12A 5hg0B-1fiwA:
undetectable		 5hg0B-1fiwA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		6 / 12 ILE A 108
VAL A  31
ILE A 103
VAL A 209
LEU A 123
ILE A 238
 None
 1.19A 5mueA-1fiwA:
undetectable		 5mueA-1fiwA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		5 / 12 HIS A  57
ASP A 102
GLY A 193
SER A 195
VAL A 217
 None
None
None
PBZ  A 305 (-2.9A)
None
 0.95A 6c2mC-1fiwA:
9.7		 6c2mC-1fiwA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1fiw BETA-ACROSIN HEAVY
CHAIN
(Ovis
aries) 		4 / 8 GLY A 216
GLY A 193
SER A 195
ALA A  55
 PBZ  A 305 (-3.4A)
None
PBZ  A 305 (-2.9A)
None
 0.76A 6hu9H-1fiwA:
undetectable
6hu9e-1fiwA:
undetectable		 6hu9H-1fiwA:
14.79
6hu9e-1fiwA:
18.21