SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fiz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
6 / 8 HIS A  57
ASP A 189
GLN A 192
SER A 195
GLY A 216
GLY A 226
None
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.6A)
PBZ  A 308 (-3.2A)
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.68A 1aq7A-1fizA:
33.8
1aq7A-1fizA:
37.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1BCU_H_PRLH280_0
(ALPHA-THROMBIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 9 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.52A 1bcuH-1fizA:
17.5
1bcuH-1fizA:
35.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
3 / 3 TRP A 232
ARG A 201
THR A 231
None
1.01A 1df7A-1fizA:
undetectable
1df7A-1fizA:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DWC_H_MITH1_1
(ALPHA-THROMBIN
(LARGE SUBUNIT))
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 9 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 226
None
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 ( 3.7A)
0.41A 1dwcH-1fizA:
34.3
1dwcH-1fizA:
35.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
6 / 12 HIS A  57
ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.54A 1etrH-1fizA:
34.1
1etrH-1fizA:
35.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 8 ASP A 189
SER A 195
GLY A 216
GLY A 226
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.43A 1f5lA-1fizA:
36.3
1f5lA-1fizA:
32.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 7 GLU A 157
LEU A 155
MET A  30
MET A 200
None
1.08A 1linA-1fizA:
undetectable
1linA-1fizA:
17.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.32A 1tnlA-1fizA:
17.0
1tnlA-1fizA:
37.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 10 THR A 190
GLY A 140
GLY A 142
ILE A 188
ALA A 158
PBZ  A 308 (-3.4A)
None
None
None
None
1.02A 1x7pA-1fizA:
undetectable
1x7pB-1fizA:
undetectable
1x7pA-1fizA:
19.47
1x7pB-1fizA:
19.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 6 ASP A 189
SER A 195
GLY A 216
GLY A 226
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.36A 2otvA-1fizA:
17.1
2otvA-1fizA:
37.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
LEU A  53
None
1.40A 2oxtD-1fizA:
undetectable
2oxtD-1fizA:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2P16_A_GG2A298_1
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
6 / 12 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 226
TYR A 228
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
None
0.41A 2p16A-1fizA:
34.1
2p16A-1fizA:
34.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 8 ASP A 189
SER A 195
GLY A 216
GLY A 226
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.33A 2vinA-1fizA:
14.1
2vinA-1fizA:
32.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2W26_A_RIVA1001_1
(ACTIVATED FACTOR XA
HEAVY CHAIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
7 / 12 ASP A 189
SER A 195
TRP A 215
GLY A 216
GLY A 219
GLY A 226
TYR A 228
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
None
PBZ  A 308 ( 3.7A)
None
0.50A 2w26A-1fizA:
16.2
2w26A-1fizA:
34.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 12 ILE A 106
ALA A 239
ALA A 246
VAL A  52
LEU A 123
None
0.94A 2yqzA-1fizA:
undetectable
2yqzA-1fizA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
3 / 3 GLY A 197
GLY A 193
GLY A  43
None
0.37A 3bogC-1fizA:
undetectable
3bogC-1fizA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 11 THR A 190
GLY A 140
GLY A 142
ILE A 188
ALA A 158
PBZ  A 308 (-3.4A)
None
None
None
None
0.97A 3dcmX-1fizA:
undetectable
3dcmX-1fizA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
7 / 11 HIS A  57
ASP A 189
GLN A 192
SER A 195
TRP A 215
GLY A 216
GLY A 226
None
PBZ  A 308 (-2.9A)
PBZ  A 308 (-3.6A)
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.56A 3gy3A-1fizA:
16.9
3gy3A-1fizA:
37.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_B_MTXB164_2
(DIHYDROFOLATE
REDUCTASE)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 4 PHE A  59
LYS A  61
ILE A 106
THR A  41
None
1.50A 3ia4B-1fizA:
undetectable
3ia4B-1fizA:
21.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 6 SER A 195
TRP A 215
GLY A 216
GLY A 226
PBZ  A 308 (-3.2A)
None
PBZ  A 308 (-3.6A)
PBZ  A 308 ( 3.7A)
0.28A 3rxfA-1fizA:
16.5
3rxfA-1fizA:
37.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_A_IL2A901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 12 THR A 231
HIS A  91
ILE A 103
LEU A  47
VAL A 250
None
1.28A 3sp9A-1fizA:
undetectable
3sp9A-1fizA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 12 THR A 231
HIS A  91
ILE A 103
LEU A  47
VAL A 250
None
1.26A 3sp9B-1fizA:
undetectable
3sp9B-1fizA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ASD_A_BAXA1500_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 6 ILE A 118
VAL A  31
LEU A  33
ILE A  65
None
0.83A 4asdA-1fizA:
undetectable
4asdA-1fizA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 10 LEU A  53
ILE A 106
ILE A 212
GLY A 196
GLY A  43
None
1.02A 4fakA-1fizA:
undetectable
4fakA-1fizA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 10 LEU A  53
ILE A 106
ILE A 212
GLY A 197
GLY A  43
None
0.94A 4fakA-1fizA:
undetectable
4fakA-1fizA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 8 GLY A 193
GLY A 140
LEU A 155
VAL A  73
None
0.84A 4fgzA-1fizA:
undetectable
4fgzA-1fizA:
18.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 5 HIS A  57
GLN A 192
GLY A 193
SER A 195
None
PBZ  A 308 (-3.6A)
None
PBZ  A 308 (-3.2A)
0.87A 4fu8A-1fizA:
36.4
4fu8A-1fizA:
32.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
3 / 3 ASP A 102
TRP A  63
SER A 195
None
None
PBZ  A 308 (-3.2A)
1.07A 4lrhB-1fizA:
undetectable
4lrhB-1fizA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
3 / 3 HIS A  40
VAL A  85
LEU A  65
None
0.71A 4m2vA-1fizA:
0.0
4m2vA-1fizA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RDX_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 7 THR A 190
GLY A 216
TYR A 228
GLY A 226
PBZ  A 308 (-3.4A)
PBZ  A 308 (-3.6A)
None
PBZ  A 308 ( 3.7A)
0.91A 4rdxA-1fizA:
undetectable
4rdxA-1fizA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 12 PHE A 203
VAL A 209
PRO A 198
THR A 139
GLY A  19
None
1.17A 4ydqB-1fizA:
undetectable
4ydqB-1fizA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
3 / 3 PRO A 233
ILE A 106
SER A 178
None
0.68A 5fsaA-1fizA:
0.0
5fsaA-1fizA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 12 ILE A 108
VAL A  31
ILE A 103
VAL A 209
LEU A 123
None
0.87A 5mueA-1fizA:
undetectable
5mueA-1fizA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 12 ILE A 108
VAL A  31
ILE A 103
VAL A 209
LEU A 123
None
0.89A 5mugA-1fizA:
undetectable
5mugA-1fizA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TWJ_D_SAMD201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
6 / 11 LEU A  53
ILE A  45
GLY A  44
GLY A  43
SER A 230
VAL A 209
None
1.40A 5twjD-1fizA:
undetectable
5twjD-1fizA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
3 / 3 LYS A  75
PRO A  75
LYS A  77
None
0.92A 5y9yA-1fizA:
0.0
5y9yA-1fizA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
5 / 12 HIS A  57
ASP A 102
GLY A 193
SER A 195
VAL A 217
None
None
None
PBZ  A 308 (-3.2A)
None
0.88A 6c2mC-1fizA:
9.5
6c2mC-1fizA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus
scrofa)
4 / 8 GLY A 216
GLY A 193
SER A 195
ALA A  55
PBZ  A 308 (-3.6A)
None
PBZ  A 308 (-3.2A)
None
0.78A 6hu9H-1fizA:
undetectable
6hu9e-1fizA:
undetectable
6hu9H-1fizA:
12.98
6hu9e-1fizA:
19.77