SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fk8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2501_0
(FERROCHELATASE)		 1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE
(Comamonas
testosteroni) 		5 / 12 LEU A  66
PHE A  97
LEU A  68
ILE A   3
VAL A  38
 None
 1.43A 1hrkB-1fk8A:
3.7		 1hrkB-1fk8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_A_STRA301_1
(MINERALOCORTICOID
RECEPTOR)		 1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE
(Comamonas
testosteroni) 		5 / 12 ASN A 152
LEU A 120
ALA A 156
SER A 158
LEU A 127
 None
 1.41A 2aa5A-1fk8A:
undetectable		 2aa5A-1fk8A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE
(Comamonas
testosteroni) 		4 / 6 ARG A  34
ASP A  32
ILE A  31
GLU A  37
 None
NAD  A 800 (-2.8A)
None
None
 1.23A 2ya7C-1fk8A:
undetectable		 2ya7C-1fk8A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z54_A_AB1A200_1
(HIV-1 PROTEASE)		 1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE
(Comamonas
testosteroni) 		5 / 12 ALA A  40
ASP A  41
GLY A  89
VAL A   5
ILE A  31
 None
NAD  A 800 (-3.3A)
None
None
None
 1.08A 2z54A-1fk8A:
undetectable		 2z54A-1fk8A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_1
(PROTEASE)		 1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE
(Comamonas
testosteroni) 		5 / 11 ALA A  40
ASP A  41
GLY A  89
VAL A   5
ILE A  31
 None
NAD  A 800 (-3.3A)
None
None
None
 1.05A 3el1A-1fk8A:
undetectable		 3el1A-1fk8A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE
(Comamonas
testosteroni) 		5 / 11 GLY A  89
ALA A  90
ILE A 112
GLY A  71
LEU A  72
 None
None
NAD  A 800 (-3.8A)
NAD  A 800 (-3.5A)
NAD  A 800 (-4.4A)
 0.94A 3em4A-1fk8A:
undetectable		 3em4A-1fk8A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE
(Comamonas
testosteroni) 		5 / 9 ALA A  40
ASP A  41
GLY A  89
VAL A   5
ILE A  31
 None
NAD  A 800 (-3.3A)
None
None
None
 1.09A 3em4B-1fk8A:
undetectable		 3em4B-1fk8A:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE
(Comamonas
testosteroni) 		5 / 9 VAL A 111
ALA A 109
ILE A   4
THR A  17
ILE A 112
 None
None
None
None
NAD  A 800 (-3.8A)
 1.25A 3hbbB-1fk8A:
undetectable		 3hbbB-1fk8A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_1
(PROTEASE)		 1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE
(Comamonas
testosteroni) 		5 / 12 ALA A  40
ASP A  41
GLY A  89
VAL A   5
ILE A  31
 None
NAD  A 800 (-3.3A)
None
None
None
 1.03A 3ndwA-1fk8A:
undetectable		 3ndwA-1fk8A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDW_A_RITA100_2
(PROTEASE)		 1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE
(Comamonas
testosteroni) 		5 / 9 ALA A  40
ASP A  41
GLY A  89
VAL A   5
ILE A  31
 None
NAD  A 800 (-3.3A)
None
None
None
 1.11A 3ndwB-1fk8A:
undetectable		 3ndwB-1fk8A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_1
(PROTEASE)		 1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE
(Comamonas
testosteroni) 		5 / 12 ALA A  40
ASP A  41
GLY A  89
VAL A   5
ILE A  31
 None
NAD  A 800 (-3.3A)
None
None
None
 1.03A 3ndxA-1fk8A:
undetectable		 3ndxA-1fk8A:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UFN_A_ROCA402_1
(HIV-1 PROTEASE)		 1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE
(Comamonas
testosteroni) 		4 / 5 ARG A 169
LEU A 180
VAL A 111
ASP A  95
 None
 0.84A 3ufnA-1fk8A:
undetectable
3ufnB-1fk8A:
0.0		 3ufnA-1fk8A:
16.34
3ufnB-1fk8A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE
(Comamonas
testosteroni) 		5 / 8 ILE A  13
GLY A  14
VAL A 225
SER A 231
ARG A 179
 NAD  A 800 (-4.1A)
None
None
None
None
 1.50A 4acbB-1fk8A:
3.9
4acbC-1fk8A:
5.7		 4acbB-1fk8A:
22.18
4acbC-1fk8A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE
(Comamonas
testosteroni) 		5 / 8 VAL A 110
ILE A 183
ALA A 184
VAL A 166
HIS A 238
 None
 1.42A 5l94A-1fk8A:
0.0		 5l94A-1fk8A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1fk8 3ALPHA-HYDROXYSTEROI
D
DEHYDROGENASE/CARBON
YL REDUCTASE
(Comamonas
testosteroni) 		4 / 8 SER A 117
THR A 163
VAL A 166
ILE A 242
 None
 1.09A 5vkqB-1fk8A:
0.0
5vkqC-1fk8A:
0.0		 5vkqB-1fk8A:
10.22
5vkqC-1fk8A:
10.22