SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fkm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_C_AG2C7004_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 6 ALA A 581
LEU A 488
LEU A 454
LEU A 602
 None
 0.98A 1mt1D-1fkmA:
undetectable
1mt1E-1fkmA:
undetectable		 1mt1D-1fkmA:
13.28
1mt1E-1fkmA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		5 / 11 MET A 494
GLY A 379
MET A 489
ASN A 381
ILE A 380
 None
 1.46A 1odiA-1fkmA:
undetectable		 1odiA-1fkmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		5 / 11 MET A 494
GLY A 379
MET A 489
ASN A 381
ILE A 380
 None
 1.43A 1odiC-1fkmA:
undetectable		 1odiC-1fkmA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 392
GLU A 389
THR A 344
TYR A 351
 None
 0.69A 1qvtA-1fkmA:
0.0		 1qvtA-1fkmA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 424
LYS A 311
ARG A 310
 None
 0.86A 1ra8A-1fkmA:
undetectable		 1ra8A-1fkmA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		3 / 3 TRP A 367
ARG A 370
PHE A 426
 None
 1.42A 1zeaH-1fkmA:
undetectable
1zeaL-1fkmA:
undetectable		 1zeaH-1fkmA:
20.49
1zeaL-1fkmA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 381
ILE A 348
MET A 494
 None
 0.79A 2h42C-1fkmA:
0.0		 2h42C-1fkmA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		3 / 3 LEU A 433
TYR A 440
GLY A 446
 None
 0.54A 2ocuA-1fkmA:
undetectable		 2ocuA-1fkmA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 387
PHE A 391
TRP A 290
GLY A 295
 None
 1.25A 2qmzA-1fkmA:
0.0
2qmzB-1fkmA:
undetectable		 2qmzA-1fkmA:
20.25
2qmzB-1fkmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 488
LEU A 619
ALA A 622
PHE A 574
 None
 1.00A 2vcvG-1fkmA:
1.5		 2vcvG-1fkmA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 488
LEU A 619
ALA A 622
PHE A 574
 None
 0.83A 2vcvP-1fkmA:
0.6		 2vcvP-1fkmA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 7 GLN A 603
PHE A 479
LEU A 488
PHE A 492
 None
 1.00A 2zxwC-1fkmA:
0.0
2zxwJ-1fkmA:
0.0		 2zxwC-1fkmA:
20.41
2zxwJ-1fkmA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 603
PHE A 479
LEU A 488
PHE A 492
 None
 1.00A 3ablC-1fkmA:
0.0
3ablJ-1fkmA:
0.0		 3ablC-1fkmA:
20.41
3ablJ-1fkmA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 603
PHE A 479
LEU A 488
PHE A 492
 None
 1.16A 3ablP-1fkmA:
0.0
3ablW-1fkmA:
0.0		 3ablP-1fkmA:
20.41
3ablW-1fkmA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 603
PHE A 479
LEU A 488
PHE A 492
 None
 1.01A 3ag1C-1fkmA:
0.0
3ag1J-1fkmA:
0.0		 3ag1C-1fkmA:
20.41
3ag1J-1fkmA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_D_ADND438_2
(ADENOSYLHOMOCYSTEINA
SE)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 4 GLN A 493
THR A 607
GLU A 491
HIS A 575
 None
 1.45A 3g1uD-1fkmA:
undetectable		 3g1uD-1fkmA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GLQ_B_RABB602_2
(ADENOSYLHOMOCYSTEINA
SE)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 493
THR A 607
GLU A 491
HIS A 575
 None
 1.48A 3glqB-1fkmA:
undetectable		 3glqB-1fkmA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 493
THR A 607
GLU A 491
HIS A 575
 None
 1.46A 3n58A-1fkmA:
undetectable		 3n58A-1fkmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 5 GLN A 493
THR A 607
GLU A 491
HIS A 575
 None
 1.45A 3n58C-1fkmA:
undetectable		 3n58C-1fkmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 4 GLN A 493
THR A 607
GLU A 491
HIS A 575
 None
 1.43A 3n58D-1fkmA:
undetectable		 3n58D-1fkmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_A_EVPA1_1
(DNA TOPOISOMERASE
2-BETA)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 379
ASP A 382
ARG A 482
GLN A 450
 None
 1.26A 3qx3A-1fkmA:
0.0		 3qx3A-1fkmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QX3_D_EVPD1_1
(DNA TOPOISOMERASE
2-BETA)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 379
ASP A 382
ARG A 482
GLN A 450
 None
 1.27A 3qx3B-1fkmA:
0.0		 3qx3B-1fkmA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		5 / 10 MET A 494
GLY A 379
MET A 489
ASN A 381
ILE A 380
 None
 1.41A 3uayA-1fkmA:
undetectable		 3uayA-1fkmA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 382
ARG A 490
ASP A 340
 None
 0.87A 4fzvA-1fkmA:
undetectable		 4fzvA-1fkmA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KMU_H_RFPH1401_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		5 / 12 GLN A 270
ASP A 259
SER A 277
LEU A 293
ILE A 281
 None
 1.21A 4kmuH-1fkmA:
0.6		 4kmuH-1fkmA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWX_A_ZMRA513_2
(NEURAMINIDASE)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		3 / 3 ARG A 286
TRP A 290
ILE A 498
 None
 1.11A 4mwxA-1fkmA:
undetectable		 4mwxA-1fkmA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJ4_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 8 LEU A 454
LEU A 457
VAL A 458
ILE A 584
 None
 0.77A 4oj4A-1fkmA:
0.0		 4oj4A-1fkmA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		4 / 6 GLN A 603
PHE A 479
LEU A 488
PHE A 492
 None
 1.14A 5b1bC-1fkmA:
0.0
5b1bJ-1fkmA:
0.0		 5b1bC-1fkmA:
20.41
5b1bJ-1fkmA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1fkm PROTEIN (GYP1P)
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 578
LEU A 383
HIS A 575
ARG A 499
LEU A 505
 None
 1.34A 5m50E-1fkmA:
undetectable		 5m50E-1fkmA:
22.56