SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fl2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F
(Escherichia
coli) 		5 / 12 ILE A 499
ALA A 500
ALA A 486
THR A 490
VAL A 492
 None
FAD  A 522 (-3.3A)
None
None
None
 1.08A 1cbsA-1fl2A:
undetectable		 1cbsA-1fl2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F
(Escherichia
coli) 		5 / 10 GLU A 385
GLY A 367
GLY A 364
ILE A 409
LEU A 384
 None
 1.02A 1x7pA-1fl2A:
3.1
1x7pB-1fl2A:
undetectable		 1x7pA-1fl2A:
24.63
1x7pB-1fl2A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F
(Escherichia
coli) 		5 / 12 ILE A 499
ALA A 500
ALA A 486
THR A 490
VAL A 492
 None
FAD  A 522 (-3.3A)
None
None
None
 1.09A 2fr3A-1fl2A:
undetectable		 2fr3A-1fl2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F
(Escherichia
coli) 		5 / 9 THR A 322
VAL A 462
THR A 478
ILE A 318
VAL A 483
 FAD  A 522 (-4.1A)
None
None
None
None
 1.29A 2l8mA-1fl2A:
0.0		 2l8mA-1fl2A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F
(Escherichia
coli) 		4 / 8 ILE A 470
LEU A 458
VAL A 218
GLY A 219
 None
None
FAD  A 522 (-4.9A)
FAD  A 522 (-3.3A)
 0.87A 3w1wA-1fl2A:
undetectable		 3w1wA-1fl2A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJZ_A_BEZA1001_0
(BENZOATE-COENZYME A
LIGASE)		 1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F
(Escherichia
coli) 		4 / 8 ALA A 486
GLY A 504
ALA A 227
GLY A 224
 None
 0.68A 4zjzA-1fl2A:
undetectable		 4zjzA-1fl2A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F
(Escherichia
coli) 		6 / 12 GLY A 271
GLY A 239
VAL A 282
ILE A 217
GLY A 247
GLY A 246
 None
None
None
None
FAD  A 522 (-3.2A)
None
 1.35A 5koxA-1fl2A:
12.3		 5koxA-1fl2A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F
(Escherichia
coli) 		4 / 7 GLY A 363
GLU A 385
ALA A 387
ASN A 365
 None
 0.94A 5mvsA-1fl2A:
undetectable		 5mvsA-1fl2A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F
(Escherichia
coli) 		4 / 8 GLY A 363
GLU A 385
ALA A 387
ASN A 365
 None
 0.92A 5mvsB-1fl2A:
undetectable		 5mvsB-1fl2A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_D_AQ4D602_0
(CYTOCHROME P450 1A1)		 1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F
(Escherichia
coli) 		5 / 12 SER A 508
GLY A 235
ALA A 232
ASP A 281
ILE A 217
 None
 1.11A 6dwnD-1fl2A:
0.0		 6dwnD-1fl2A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1fl2 ALKYL HYDROPEROXIDE
REDUCTASE SUBUNIT F
(Escherichia
coli) 		4 / 8 ILE A 498
THR A 252
VAL A 253
GLU A 265
 None
FAD  A 522 (-3.5A)
None
None
 1.07A 6fbvC-1fl2A:
0.0		 6fbvC-1fl2A:
14.59