SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1flc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus;
Influenza
C
virus) 		5 / 12 LEU B  93
LEU B  92
SER B  89
LEU A  36
ILE A 408
 None
 1.11A 1fmlA-1flcB:
undetectable		 1fmlA-1flcB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus;
Influenza
C
virus) 		5 / 12 LEU B  93
LEU B  92
SER B  89
LEU A  36
ILE A 408
 None
 1.11A 1fmlB-1flcB:
undetectable		 1fmlB-1flcB:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		4 / 7 GLU A 298
THR A 167
VAL A 166
ALA A 183
 None
 1.05A 1fo4B-1flcA:
undetectable		 1fo4B-1flcA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K4T_D_TTCD990_1
(DNA TOPOISOMERASE I)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		4 / 5 GLU B  95
LYS A 395
ASP B  73
THR B  81
 None
 1.35A 1k4tA-1flcB:
4.9		 1k4tA-1flcB:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RR8_A_TTCA100_1
(DNA TOPOISOMERASE I)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		4 / 5 GLU B  95
LYS A 395
ASP B  73
THR B  81
 None
 1.32A 1rr8C-1flcB:
0.0		 1rr8C-1flcB:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RRJ_B_TTCB990_1
(DNA TOPOISOMERASE I)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		4 / 5 GLU B  95
LYS A 395
ASP B  73
THR B  81
 None
 1.28A 1rrjA-1flcB:
0.0		 1rrjA-1flcB:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_G_BEZG2352_0
(D-AMINO-ACID OXIDASE)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		4 / 5 TYR A 103
TYR A 301
ILE A 142
GLY A  86
 None
 1.29A 2du8G-1flcA:
undetectable		 2du8G-1flcA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		3 / 3 LEU A 295
LEU A 278
MET A 277
 None
 0.77A 2itzA-1flcA:
undetectable		 2itzA-1flcA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		4 / 7 TYR A 113
GLY A  42
ALA A  43
LEU A 367
 None
 0.89A 2wekB-1flcA:
undetectable		 2wekB-1flcA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		4 / 7 ILE A 162
THR A 161
GLN A 165
LEU A 201
 None
 1.01A 2xrhA-1flcA:
undetectable		 2xrhA-1flcA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		4 / 5 PRO A 297
SER A 222
LEU A 158
SER A 300
 None
 1.15A 3ijxH-1flcA:
undetectable		 3ijxH-1flcA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZK_A_T44A128_1
(TRANSTHYRETIN)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		5 / 9 MET A 339
THR A 312
ALA A  43
SER A 365
VAL A 111
 None
 1.49A 3ozkA-1flcA:
0.1		 3ozkA-1flcA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus;
Influenza
C
virus) 		4 / 7 ILE B  77
PHE A 396
LYS A 108
GLY A 309
 None
 1.22A 3sj0X-1flcB:
undetectable		 3sj0X-1flcB:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_D_MIYD2001_1
(TETX2 PROTEIN)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		5 / 11 PHE A  93
GLY A  94
PHE A 138
ASN A 137
MET A 277
 None
 1.11A 3v3nD-1flcA:
1.2		 3v3nD-1flcA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		4 / 8 ASP A 325
ASP A 329
ASP A  56
ARG A  58
 None
 1.01A 4gkhF-1flcA:
undetectable		 4gkhF-1flcA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		5 / 12 LEU A   7
GLY B  44
ALA B  41
PHE B 156
PHE B 152
 None
 1.21A 4hytA-1flcA:
0.0		 4hytA-1flcA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		3 / 3 LEU B 118
ILE B 122
ARG B 125
 None
 0.69A 4mk4B-1flcB:
undetectable		 4mk4B-1flcB:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		3 / 3 SER B 134
ASP B   5
GLN A   8
 None
 0.94A 4oltA-1flcB:
0.0
4oltB-1flcB:
0.0		 4oltA-1flcB:
22.22
4oltB-1flcB:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		3 / 3 GLN A   8
SER B 134
ASP B   5
 None
 0.95A 4qwpA-1flcA:
0.0
4qwpB-1flcA:
0.0		 4qwpA-1flcA:
20.65
4qwpB-1flcA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		3 / 3 SER A 290
ASP A 247
ASP A 257
 None
 0.78A 4uckA-1flcA:
undetectable		 4uckA-1flcA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus;
Influenza
C
virus) 		5 / 12 SER B  58
ARG B 100
PHE A  34
GLY B  97
LEU B 103
 NAG  B1300 ( 4.0A)
None
None
None
None
 1.17A 4uinH-1flcB:
0.0
4uinL-1flcB:
0.0		 4uinH-1flcB:
21.19
4uinL-1flcB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus;
Influenza
C
virus) 		4 / 6 LEU B  80
PRO A 393
GLU B  85
TYR A 390
 None
 1.07A 4z4gA-1flcB:
undetectable		 4z4gA-1flcB:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		5 / 12 GLY A 414
LEU B  25
ILE A   5
GLY B  10
PHE B  45
 None
 1.18A 5eskA-1flcA:
0.0		 5eskA-1flcA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		3 / 3 GLY A 397
CYH A 399
CYH A 373
 None
 0.97A 5inzB-1flcA:
undetectable		 5inzB-1flcA:
3.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		4 / 5 ALA A  43
GLY A  53
LYS A 110
HIS A 109
 None
 1.46A 5jliA-1flcA:
undetectable		 5jliA-1flcA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_A_MMSA511_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		4 / 7 HIS A 218
LEU A 217
VAL A 220
SER A 300
 None
 0.93A 5m8rA-1flcA:
undetectable		 5m8rA-1flcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_B_MMSB514_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		4 / 8 HIS A 218
LEU A 217
VAL A 220
SER A 300
 None
 0.95A 5m8rB-1flcA:
undetectable		 5m8rB-1flcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		4 / 8 HIS A 218
LEU A 217
VAL A 220
SER A 300
 None
 0.93A 5m8rC-1flcA:
undetectable		 5m8rC-1flcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_D_MMSD509_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		4 / 8 HIS A 218
LEU A 217
VAL A 220
SER A 300
 None
 0.93A 5m8rD-1flcA:
0.0		 5m8rD-1flcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1flc HAEMAGGLUTININ-ESTER
ASE-FUSION
GLYCOPROTEIN
(Influenza
C
virus) 		3 / 3 GLY A 172
THR A 170
ASN A 176
 None
 0.70A 5odiG-1flcA:
0.5		 5odiG-1flcA:
22.62