SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1flk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1flk TNF RECEPTOR
ASSOCIATED FACTOR 3
(Homo
sapiens) 		5 / 10 LEU A 444
PHE A 473
LEU A 407
PHE A 491
ILE A 490
 None
 0.91A 1g5yC-1flkA:
undetectable		 1g5yC-1flkA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1flk TNF RECEPTOR
ASSOCIATED FACTOR 3
(Homo
sapiens) 		4 / 5 SER A 378
ALA A 392
MET A 414
LEU A 354
 None
 0.99A 5dzkb-1flkA:
undetectable
5dzkp-1flkA:
undetectable		 5dzkb-1flkA:
21.94
5dzkp-1flkA:
1.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1flk TNF RECEPTOR
ASSOCIATED FACTOR 3
(Homo
sapiens) 		4 / 5 SER A 378
ALA A 392
MET A 414
LEU A 354
 None
 1.08A 5dzkc-1flkA:
undetectable
5dzkq-1flkA:
undetectable		 5dzkc-1flkA:
21.94
5dzkq-1flkA:
1.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1flk TNF RECEPTOR
ASSOCIATED FACTOR 3
(Homo
sapiens) 		4 / 5 SER A 378
ALA A 392
MET A 414
LEU A 354
 None
 1.02A 5dzkf-1flkA:
undetectable
5dzkt-1flkA:
undetectable		 5dzkf-1flkA:
21.94
5dzkt-1flkA:
1.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1flk TNF RECEPTOR
ASSOCIATED FACTOR 3
(Homo
sapiens) 		4 / 6 SER A 378
ALA A 392
MET A 414
LEU A 354
 None
 1.04A 5dzkg-1flkA:
undetectable
5dzku-1flkA:
undetectable		 5dzkg-1flkA:
21.94
5dzku-1flkA:
1.37