SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1flz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		4 / 7 TYR A  66
VAL A  79
TYR A  93
GLY A 109
 URA  A 230 (-3.2A)
None
None
None
 0.92A 11gsA-1flzA:
undetectable		 11gsA-1flzA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		5 / 9 THR A 124
LEU A  61
ILE A 152
ASP A 146
ILE A 174
 None
 1.39A 1gebA-1flzA:
0.0		 1gebA-1flzA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		4 / 6 GLY A 109
SER A  78
LEU A 224
HIS A  73
 None
 0.86A 1yajF-1flzA:
0.8		 1yajF-1flzA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		4 / 8 LEU A 121
ARG A 116
PRO A 106
VAL A 223
 None
 1.16A 2qd2A-1flzA:
1.4		 2qd2A-1flzA:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		4 / 8 GLY A  62
GLN A  63
PHE A  77
ASN A 123
 URA  A 230 ( 4.1A)
None
URA  A 230 (-3.6A)
URA  A 230 (-2.9A)
 0.94A 4wryA-1flzA:
30.8		 4wryA-1flzA:
36.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		6 / 8 GLY A  62
TYR A  66
PHE A  77
SER A  88
ASN A 123
HIS A 187
 URA  A 230 ( 4.1A)
URA  A 230 (-3.2A)
URA  A 230 (-3.6A)
URA  A 230 ( 4.9A)
URA  A 230 (-2.9A)
URA  A 230 (-4.1A)
 0.38A 4wryA-1flzA:
30.8		 4wryA-1flzA:
36.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		4 / 8 GLY A  62
GLN A  63
PHE A  77
ASN A 123
 URA  A 230 ( 4.1A)
None
URA  A 230 (-3.6A)
URA  A 230 (-2.9A)
 0.92A 4wrzA-1flzA:
30.7		 4wrzA-1flzA:
36.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		4 / 8 GLY A  62
PHE A  77
SER A 189
ASN A 123
 URA  A 230 ( 4.1A)
URA  A 230 (-3.6A)
None
URA  A 230 (-2.9A)
 0.89A 4wrzA-1flzA:
30.7		 4wrzA-1flzA:
36.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WRZ_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		6 / 8 GLY A  62
TYR A  66
PHE A  77
SER A  88
ASN A 123
HIS A 187
 URA  A 230 ( 4.1A)
URA  A 230 (-3.2A)
URA  A 230 (-3.6A)
URA  A 230 ( 4.9A)
URA  A 230 (-2.9A)
URA  A 230 (-4.1A)
 0.38A 4wrzA-1flzA:
30.7		 4wrzA-1flzA:
36.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS0_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		5 / 7 GLY A  62
TYR A  66
PHE A  77
ASN A 123
HIS A 187
 URA  A 230 ( 4.1A)
URA  A 230 (-3.2A)
URA  A 230 (-3.6A)
URA  A 230 (-2.9A)
URA  A 230 (-4.1A)
 0.29A 4ws0A-1flzA:
30.3		 4ws0A-1flzA:
36.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4WS1_A_URFA301_1
(URACIL-DNA
GLYCOSYLASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		6 / 8 GLY A  62
TYR A  66
PHE A  77
SER A  88
ASN A 123
HIS A 187
 URA  A 230 ( 4.1A)
URA  A 230 (-3.2A)
URA  A 230 (-3.6A)
URA  A 230 ( 4.9A)
URA  A 230 (-2.9A)
URA  A 230 (-4.1A)
 0.32A 4ws1A-1flzA:
30.3		 4ws1A-1flzA:
36.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		5 / 12 GLY A 140
LEU A 122
LEU A  11
PHE A  45
THR A 143
 None
 1.28A 4ze1A-1flzA:
0.0		 4ze1A-1flzA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_1
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 1flz URACIL-DNA
GLYCOSYLASE
(Escherichia
coli) 		3 / 3 ASP A  64
SER A 189
SER A  88
 None
None
URA  A 230 ( 4.9A)
 0.69A 6mxtA-1flzA:
0.0		 6mxtA-1flzA:
18.37