SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fn4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		4 / 6 LEU A 104
VAL A  19
VAL A  15
GLN A  79
 None
 1.00A 1e7aB-1fn4A:
undetectable		 1e7aB-1fn4A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		4 / 5 PRO A  80
LEU A 106
THR A  74
ARG A  18
 None
 1.27A 1i2wA-1fn4A:
undetectable		 1i2wA-1fn4A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		4 / 7 LEU B  82
MET B  82
LEU B  80
MET B  48
 None
 0.94A 1linA-1fn4B:
undetectable		 1linA-1fn4B:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		4 / 7 THR A  69
ASN A  93
LEU A   4
GLN A  90
 None
 1.02A 1qzrB-1fn4A:
0.0		 1qzrB-1fn4A:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YMX_A_CFXA1001_2
(BETA-LACTAMASE
CTX-M-9)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		4 / 5 TYR B  97
PRO B 100
THR A  51
SER A  53
 None
 0.93A 1ymxA-1fn4B:
undetectable		 1ymxA-1fn4B:
25.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		4 / 8 SER B 112
VAL B 114
VAL B 190
TYR B 138
 None
 1.05A 2ddwA-1fn4B:
undetectable		 2ddwA-1fn4B:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		3 / 3 LEU A 157
LEU A 132
MET A 133
 None
 0.87A 2itzA-1fn4A:
undetectable		 2itzA-1fn4A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		3 / 3 TYR B 168
GLY B 137
PHE B 139
 None
 0.65A 2m2pB-1fn4B:
undetectable		 2m2pB-1fn4B:
9.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OLD_B_IPHB2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus;
Rattus
norvegicus) 		5 / 7 HIS B  39
PRO B  45
TYR B  91
TYR A  36
PRO A  44
 None
 1.19A 2oldA-1fn4B:
18.1
2oldB-1fn4B:
12.8		 2oldA-1fn4B:
31.36
2oldB-1fn4B:
31.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 5 HIS B  39
PRO B  45
TYR B  91
TYR A  36
 None
 0.81A 2ombA-1fn4B:
18.0
2ombB-1fn4B:
5.5		 2ombA-1fn4B:
31.36
2ombB-1fn4B:
31.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus;
Rattus
norvegicus) 		4 / 7 TYR A  36
HIS B  39
PRO B  45
TYR B  91
 None
 0.73A 2ombC-1fn4A:
17.6
2ombD-1fn4A:
19.7		 2ombC-1fn4A:
42.79
2ombD-1fn4A:
42.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		4 / 7 VAL B 109
VAL B 111
SER B 113
VAL B 199
 None
 0.92A 3hs6B-1fn4B:
undetectable		 3hs6B-1fn4B:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		5 / 12 LEU B 152
VAL B 174
ILE B 203
LEU B 131
VAL B 199
 None
 1.11A 4y0qA-1fn4B:
0.0		 4y0qA-1fn4B:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		4 / 8 SER A 113
THR A 111
SER A 171
THR B 175
 None
 0.88A 5l4eA-1fn4A:
1.2
5l4eB-1fn4A:
3.3
5l4eC-1fn4A:
2.0
5l4eD-1fn4A:
1.9
5l4eE-1fn4A:
1.0		 5l4eA-1fn4A:
20.25
5l4eB-1fn4A:
20.25
5l4eC-1fn4A:
20.25
5l4eD-1fn4A:
20.25
5l4eE-1fn4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		4 / 8 THR B 175
SER A 113
THR A 111
SER A 171
 None
 0.92A 5l4eA-1fn4B:
undetectable
5l4eB-1fn4B:
undetectable
5l4eC-1fn4B:
undetectable
5l4eD-1fn4B:
0.0
5l4eE-1fn4B:
undetectable		 5l4eA-1fn4B:
19.81
5l4eB-1fn4B:
19.81
5l4eC-1fn4B:
19.81
5l4eD-1fn4B:
19.81
5l4eE-1fn4B:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		3 / 3 THR B 125
PRO B 205
ARG B 206
 None
 0.82A 5nd7B-1fn4B:
undetectable		 5nd7B-1fn4B:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		3 / 3 LEU A 104
ALA A  84
LEU A  78
 None
 0.55A 5uunB-1fn4A:
undetectable		 5uunB-1fn4A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		4 / 5 VAL B  34
PRO B 100
GLY B 100
TYR B 100
 None
 1.03A 5x80A-1fn4B:
undetectable
5x80B-1fn4B:
undetectable		 5x80A-1fn4B:
19.82
5x80B-1fn4B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_C_SALC201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		4 / 7 VAL B  34
PRO B 100
GLY B 100
TYR B 100
 None
 1.00A 5x80C-1fn4B:
undetectable
5x80D-1fn4B:
undetectable		 5x80C-1fn4B:
19.82
5x80D-1fn4B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_D_SALD201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		4 / 5 PRO B 100
GLY B 100
TYR B 100
VAL B  34
 None
 0.96A 5x80C-1fn4B:
undetectable
5x80D-1fn4B:
undetectable		 5x80C-1fn4B:
19.82
5x80D-1fn4B:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1fn4 MONOCLONAL ANTIBODY
AGAINST
ACETYLCHOLINE
RECEPTOR
(Rattus
norvegicus) 		5 / 12 LEU A  21
SER A 168
THR A  74
ARG A  18
GLY A  16
 None
 1.17A 6b0lB-1fn4A:
undetectable		 6b0lB-1fn4A:
18.91