SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fn9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		5 / 10 GLY A 350
LEU A 242
TYR A 238
ARG A 186
TYR A 225
 None
 1.32A 1pbcA-1fn9A:
undetectable		 1pbcA-1fn9A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		4 / 6 LEU A 228
TYR A 225
ILE A 180
GLY A 350
 None
 0.77A 2du8A-1fn9A:
undetectable		 2du8A-1fn9A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		4 / 6 LEU A 228
TYR A 225
ILE A 180
GLY A 350
 None
 0.76A 2du8B-1fn9A:
undetectable		 2du8B-1fn9A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OA1_B_ADNB2005_1
(TRYPTOPHAN
HALOGENASE)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		4 / 7 GLY A 319
GLY A 318
VAL A 302
LEU A   5
 None
 0.75A 2oa1B-1fn9A:
undetectable		 2oa1B-1fn9A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		4 / 7 MET A 184
ILE A 174
PRO A 344
GLY A 250
 None
 1.14A 2pnjB-1fn9A:
undetectable		 2pnjB-1fn9A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		3 / 3 LEU A 128
ARG A 122
ILE A 363
 None
 0.69A 2xn5B-1fn9A:
0.0		 2xn5B-1fn9A:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		5 / 12 GLN A  10
LEU A 315
CYH A  51
ALA A  48
ALA A 314
 None
None
ZN  A1001 (-2.3A)
None
None
 1.28A 3b0wA-1fn9A:
1.1		 3b0wA-1fn9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		5 / 12 GLN A  10
LEU A 315
CYH A  51
ALA A  48
ALA A 314
 None
None
ZN  A1001 (-2.3A)
None
None
 1.31A 3b0wB-1fn9A:
0.0		 3b0wB-1fn9A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC59_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		3 / 3 GLY A 322
GLY A 316
GLY A 318
 None
 0.39A 3bogC-1fn9A:
undetectable		 3bogC-1fn9A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB200_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		4 / 5 PRO A 332
VAL A 334
THR A 321
GLY A 322
 None
 1.14A 3elzB-1fn9A:
0.0		 3elzB-1fn9A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		3 / 3 MET A   1
CYH A  51
PRO A  69
 None
ZN  A1001 (-2.3A)
None
 1.24A 3h52C-1fn9A:
0.0		 3h52C-1fn9A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		3 / 3 PHE A 272
TYR A 166
LEU A 276
 None
 0.76A 3sueB-1fn9A:
0.0		 3sueB-1fn9A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F5Z_A_BEZA302_0
(HALOALKANE
DEHALOGENASE)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		4 / 8 ASN A 353
PHE A 349
VAL A 243
TYR A 238
 None
 1.06A 4f5zA-1fn9A:
undetectable		 4f5zA-1fn9A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		3 / 3 ARG A 202
ASP A 224
ASP A 360
 None
 0.67A 4kicB-1fn9A:
undetectable		 4kicB-1fn9A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		4 / 8 THR A 204
THR A 262
LEU A 197
VAL A 356
 None
 0.91A 4l4eA-1fn9A:
0.0		 4l4eA-1fn9A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		4 / 8 THR A 204
THR A 262
LEU A 197
VAL A 356
 None
 0.93A 4l4fA-1fn9A:
0.0		 4l4fA-1fn9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		3 / 3 VAL A 302
LEU A  68
MET A  42
 None
 0.45A 5ikrA-1fn9A:
0.0		 5ikrA-1fn9A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		4 / 6 ARG A 208
ALA A 191
PRO A 188
PHE A 285
 None
 1.31A 5odqA-1fn9A:
undetectable		 5odqA-1fn9A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		3 / 3 LEU A 131
ASN A 139
LEU A 265
 None
 0.68A 6exiA-1fn9A:
undetectable		 6exiA-1fn9A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G1P_A_ACTA403_0
(ADP-RIBOSYLHYDROLASE
LIKE 2)		 1fn9 OUTER-CAPSID PROTEIN
SIGMA 3
(Reovirus
sp.) 		3 / 3 TYR A 166
ASP A 164
GLN A 165
 None
 0.83A 6g1pA-1fn9A:
0.0		 6g1pA-1fn9A:
22.74