SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fnf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U1J_A_C2FA773_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1fnf FIBRONECTIN
(Homo
sapiens) 		4 / 8 ARG A1270
ASN A1276
SER A1272
ARG A1320
 None
 1.30A 1u1jA-1fnfA:
undetectable		 1u1jA-1fnfA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1fnf FIBRONECTIN
(Homo
sapiens) 		3 / 3 ARG A1358
ARG A1360
ILE A1410
 None
 0.74A 1uobA-1fnfA:
0.0		 1uobA-1fnfA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D55_C_DVAC2_0
(ACTINOMYCIN D)		 1fnf FIBRONECTIN
(Homo
sapiens) 		3 / 3 THR A1157
PRO A1155
PRO A1237
 None
 0.78A 2d55C-1fnfA:
undetectable		 2d55C-1fnfA:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1fnf FIBRONECTIN
(Homo
sapiens) 		4 / 5 SER A1272
VAL A1280
SER A1306
VAL A1304
 None
 1.32A 2j9cA-1fnfA:
undetectable
2j9cB-1fnfA:
undetectable
2j9cC-1fnfA:
0.0		 2j9cA-1fnfA:
15.76
2j9cB-1fnfA:
15.76
2j9cC-1fnfA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 1fnf FIBRONECTIN
(Homo
sapiens) 		4 / 6 THR A1301
GLU A1302
MET A1252
PHE A1244
 None
 1.41A 2w98B-1fnfA:
undetectable		 2w98B-1fnfA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1fnf FIBRONECTIN
(Homo
sapiens) 		4 / 8 ILE A1232
LEU A1149
THR A1157
VAL A1162
 None
 0.83A 3dcjB-1fnfA:
undetectable		 3dcjB-1fnfA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP1_A_ACTA590_0
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1fnf FIBRONECTIN
(Homo
sapiens) 		4 / 5 GLU A1211
LEU A1210
HIS A1314
GLY A1209
 None
 1.02A 3pp1A-1fnfA:
0.0		 3pp1A-1fnfA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 1fnf FIBRONECTIN
(Homo
sapiens) 		5 / 10 THR A1353
ASN A1401
TYR A1357
GLY A1300
ALA A1352
 None
 1.39A 3pp7B-1fnfA:
undetectable		 3pp7B-1fnfA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 1fnf FIBRONECTIN
(Homo
sapiens) 		4 / 6 GLY A1300
THR A1301
LEU A1298
ASP A1328
 None
 0.86A 3ps9A-1fnfA:
undetectable		 3ps9A-1fnfA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1fnf FIBRONECTIN
(Homo
sapiens) 		4 / 6 ILE A1172
THR A1169
VAL A1194
SER A1225
 None
 1.05A 4iaqA-1fnfA:
undetectable		 4iaqA-1fnfA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 1fnf FIBRONECTIN
(Homo
sapiens) 		3 / 3 ASP A1204
LEU A1190
VAL A1216
 None
 0.72A 4jecB-1fnfA:
0.0		 4jecB-1fnfA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1fnf FIBRONECTIN
(Homo
sapiens) 		4 / 7 ILE A1485
VAL A1425
ALA A1428
THR A1429
 None
 0.97A 6cduC-1fnfA:
2.4
6cduD-1fnfA:
2.2		 6cduC-1fnfA:
24.34
6cduD-1fnfA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_F_EY4F500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1fnf FIBRONECTIN
(Homo
sapiens) 		4 / 7 ALA A1428
THR A1429
ILE A1485
VAL A1425
 None
 0.96A 6cduF-1fnfA:
2.0
6cduJ-1fnfA:
1.7		 6cduF-1fnfA:
24.34
6cduJ-1fnfA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 1fnf FIBRONECTIN
(Homo
sapiens) 		4 / 6 LEU A1297
THR A1325
GLY A1300
ARG A1351
 None
 1.09A 6gtqB-1fnfA:
0.0
6gtqD-1fnfA:
undetectable		 6gtqB-1fnfA:
19.06
6gtqD-1fnfA:
13.11