SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fng'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 1fng PROTEIN (MHC CLASS
II I-EK, BETA CHAIN)
(Mus
musculus) 		4 / 7 GLN B 156
ASP B 121
LEU B 180
SER B 118
 None
 1.19A 1ig3A-1fngB:
undetectable
1ig3B-1fngB:
undetectable		 1ig3A-1fngB:
22.97
1ig3B-1fngB:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 1fng PROTEIN (MHC CLASS
II I-EK, BETA CHAIN)
(Mus
musculus) 		4 / 8 PHE B 122
THR B 145
VAL B 129
ILE B 127
 None
 0.67A 2qbmA-1fngB:
undetectable		 2qbmA-1fngB:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1fng PROTEIN (MHC CLASS
II I-EK, BETA CHAIN)
(Mus
musculus) 		3 / 3 LEU B  38
ARG B  72
ASN B   5
 None
 0.62A 3qxvD-1fngB:
5.8		 3qxvD-1fngB:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 1fng PROTEIN (MHC CLASS
II I-EK, BETA CHAIN)
(Mus
musculus) 		4 / 8 THR B 100
SER B 118
THR B  98
SER B 120
 None
 0.91A 5l4eA-1fngB:
2.6
5l4eB-1fngB:
2.6
5l4eC-1fngB:
2.3
5l4eD-1fngB:
2.6
5l4eE-1fngB:
2.6		 5l4eA-1fngB:
22.47
5l4eB-1fngB:
22.47
5l4eC-1fngB:
22.47
5l4eD-1fngB:
22.47
5l4eE-1fngB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_D_ERMD1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 1fng PROTEIN (MHC CLASS
II I-EK, BETA CHAIN)
(Mus
musculus) 		4 / 6 LEU B 161
VAL B 159
THR B 157
GLU B 187
 None
 0.80A 5tudD-1fngB:
undetectable		 5tudD-1fngB:
18.08