SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fnn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 11 ILE A  90
ALA A  88
LEU A 136
LEU A 128
ILE A  93
 None
 1.02A 1dhiB-1fnnA:
undetectable		 1dhiB-1fnnA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  90
ALA A  88
LEU A 136
LEU A 128
ILE A  93
 None
 1.04A 1draB-1fnnA:
undetectable		 1draB-1fnnA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  90
ALA A  88
LEU A 136
LEU A 128
ILE A  93
 None
 1.00A 1drbB-1fnnA:
undetectable		 1drbB-1fnnA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		4 / 7 ILE A  99
PHE A 111
PHE A  86
PHE A 144
 None
 1.12A 1e71M-1fnnA:
0.4		 1e71M-1fnnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		4 / 7 ILE A  99
PHE A 111
PHE A  86
PHE A 144
 None
 1.13A 1e72M-1fnnA:
0.4		 1e72M-1fnnA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 12 LEU A 209
ALA A 250
LEU A 246
ALA A 242
ILE A 222
 None
 1.04A 1fk6A-1fnnA:
undetectable		 1fk6A-1fnnA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		4 / 5 ARG A 267
ASP A 312
SER A 316
SER A 303
 None
 1.33A 1kiaB-1fnnA:
undetectable		 1kiaB-1fnnA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		4 / 6 ARG A 267
ASP A 312
SER A 316
SER A 303
 None
 1.33A 1kiaC-1fnnA:
undetectable		 1kiaC-1fnnA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  90
ALA A  88
LEU A 136
LEU A 128
ILE A  93
 None
 1.02A 1rb2A-1fnnA:
undetectable		 1rb2A-1fnnA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_B_FOLB161_0
(DIHYDROFOLATE
REDUCTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  90
ALA A  88
LEU A 136
LEU A 128
ILE A  93
 None
 1.12A 1rb2B-1fnnA:
undetectable		 1rb2B-1fnnA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  89
MET A 126
PHE A 144
LEU A 112
ILE A  90
 None
 1.00A 1rx2A-1fnnA:
undetectable		 1rx2A-1fnnA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 10 LEU A 246
VAL A   8
VAL A   3
TYR A 214
PRO A  15
 None
None
None
None
ADP  A 398 (-4.7A)
 1.46A 1sv5A-1fnnA:
0.0		 1sv5A-1fnnA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		4 / 8 THR A  54
VAL A 164
GLY A 165
ILE A 187
 ADP  A 398 (-4.5A)
None
None
None
 0.74A 2a1mB-1fnnA:
undetectable		 2a1mB-1fnnA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  90
ALA A  88
LEU A 136
LEU A 128
ILE A  93
 None
 0.94A 2d0kA-1fnnA:
undetectable		 2d0kA-1fnnA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_C_TOPC200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 11 ALA A  73
LEU A  32
LEU A  60
PHE A  75
THR A  71
 None
 1.28A 3fl9C-1fnnA:
undetectable		 3fl9C-1fnnA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 9 ALA A  73
LEU A  32
LEU A  60
PHE A  75
THR A  71
 None
 1.29A 3fl9H-1fnnA:
undetectable		 3fl9H-1fnnA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_A_EAAA212_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		4 / 7 VAL A  58
TYR A 192
THR A 193
GLY A  55
 ADP  A 398 (-3.7A)
ADP  A 398 (-4.6A)
None
ADP  A 398 (-3.3A)
 1.03A 3gssA-1fnnA:
undetectable		 3gssA-1fnnA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		4 / 7 VAL A  58
TYR A 192
THR A 193
GLY A  55
 ADP  A 398 (-3.7A)
ADP  A 398 (-4.6A)
None
ADP  A 398 (-3.3A)
 0.96A 3gssB-1fnnA:
undetectable		 3gssB-1fnnA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  90
ALA A  88
LEU A 136
LEU A 128
ILE A  93
 None
 1.00A 4ej1A-1fnnA:
undetectable		 4ej1A-1fnnA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		4 / 7 LEU A 274
THR A 226
ILE A 222
GLY A 368
 None
 0.93A 4eq4A-1fnnA:
0.6		 4eq4A-1fnnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		4 / 7 LEU A 274
THR A 226
ILE A 222
GLY A 368
 None
 0.89A 4eqlA-1fnnA:
undetectable		 4eqlA-1fnnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		4 / 7 LEU A 274
THR A 226
ILE A 222
GLY A 368
 None
 0.91A 4eqlB-1fnnA:
undetectable		 4eqlB-1fnnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  90
ALA A  88
LEU A 136
LEU A 128
ILE A  93
 None
 1.01A 4i13A-1fnnA:
undetectable		 4i13A-1fnnA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  89
MET A 126
PHE A 144
LEU A 112
ILE A  90
 None
 1.01A 4kjjA-1fnnA:
undetectable		 4kjjA-1fnnA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJK_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  89
MET A 126
PHE A 144
LEU A 112
ILE A  90
 None
 1.02A 4kjkA-1fnnA:
undetectable		 4kjkA-1fnnA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		4 / 7 LEU A 274
THR A 226
ILE A 222
GLY A 368
 None
 0.89A 4l39B-1fnnA:
0.4		 4l39B-1fnnA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		4 / 8 SER A 269
SER A 249
ILE A 218
GLU A 264
 None
 1.35A 4ms4A-1fnnA:
undetectable		 4ms4A-1fnnA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 12 ILE A  89
MET A 126
PHE A 144
LEU A 112
ILE A  90
 None
 0.98A 4p3rA-1fnnA:
undetectable		 4p3rA-1fnnA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 11 ILE A  90
ALA A  88
LEU A 136
LEU A 128
ILE A  93
 None
 1.04A 4p66A-1fnnA:
undetectable		 4p66A-1fnnA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		4 / 8 ILE A 277
GLU A 370
VAL A 273
LEU A 274
 None
 0.95A 4r38B-1fnnA:
0.0		 4r38B-1fnnA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_A_SAMA2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		3 / 3 SER A 366
ASP A 199
ASP A 217
 None
 0.70A 4uckA-1fnnA:
undetectable		 4uckA-1fnnA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 9 LEU A 202
LEU A 219
ALA A 207
VAL A   8
ARG A 204
 None
None
None
None
ADP  A 398 (-3.4A)
 1.28A 5g44A-1fnnA:
0.0		 5g44A-1fnnA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 12 VAL A 170
LEU A 136
ALA A 133
ARG A 146
LEU A 161
 None
 1.22A 5nd7B-1fnnA:
undetectable		 5nd7B-1fnnA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIH_A_8CVA201_1
(DIHYDROFOLATE
REDUCTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		4 / 8 ILE A  90
ALA A  88
LEU A 136
ILE A  93
 None
 0.85A 5uihA-1fnnA:
undetectable		 5uihA-1fnnA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 12 ILE A 140
ALA A 133
LEU A 161
PHE A 144
ILE A  93
 None
 1.31A 5z6fA-1fnnA:
undetectable		 5z6fA-1fnnA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		3 / 3 PHE A 144
ARG A 108
ALA A 137
 None
 0.87A 6ecfB-1fnnA:
undetectable		 6ecfB-1fnnA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1fnn CELL DIVISION
CONTROL PROTEIN 6
(Pyrobaculum
aerophilum) 		5 / 10 ARG A 267
LEU A 375
LEU A 372
LEU A 294
LEU A 293
 None
 0.93A 6f6nA-1fnnA:
0.0
6f6nB-1fnnA:
undetectable		 6f6nA-1fnnA:
12.88
6f6nB-1fnnA:
13.08