SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1fns VON WILLEBRAND
FACTOR
(Homo
sapiens) 		3 / 3 ASP A 514
LYS A 569
ARG A 571
 None
 0.96A 1ra8A-1fnsA:
0.0		 1ra8A-1fnsA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1fns VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 PHE A 634
TYR A 637
VAL A 638
GLU A 626
 None
 1.12A 4a97E-1fnsA:
0.0		 4a97E-1fnsA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_A_QPSA951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1fns VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 6 MET A 622
GLY A 652
GLU A 666
ARG A 663
 None
 1.26A 4bqfA-1fnsA:
4.8		 4bqfA-1fnsA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4COX_C_IMNC701_1
(CYCLOOXYGENASE-2)		 1fns VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 12 VAL A 676
LEU A 677
SER A 678
ALA A 657
LEU A 659
 None
 0.99A 4coxC-1fnsA:
0.0		 4coxC-1fnsA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1fns VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 8 LEU A 518
ALA A 618
LEU A 620
VAL A 646
 None
 0.80A 4iizB-1fnsA:
undetectable		 4iizB-1fnsA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fns VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 12 VAL A 676
LEU A 677
SER A 678
ALA A 657
LEU A 659
 None
 1.20A 4rrwB-1fnsA:
undetectable		 4rrwB-1fnsA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_B_LURB705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fns VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 12 VAL A 676
LEU A 677
SER A 678
ALA A 657
LEU A 659
 None
 1.20A 4rrzB-1fnsA:
undetectable		 4rrzB-1fnsA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RS0_A_IBPA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fns VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 9 VAL A 676
LEU A 677
SER A 678
ALA A 657
LEU A 659
 None
 1.09A 4rs0A-1fnsA:
0.0		 4rs0A-1fnsA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UH3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1fns VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 PHE A 536
GLU A 542
MET A 541
VAL A 691
 None
 1.41A 4uh3A-1fnsA:
0.4
4uh3B-1fnsA:
0.4		 4uh3A-1fnsA:
19.90
4uh3B-1fnsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADA_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1fns VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 PHE A 536
GLU A 542
MET A 541
VAL A 691
 None
 1.38A 5adaA-1fnsA:
0.4
5adaB-1fnsA:
0.0		 5adaA-1fnsA:
19.90
5adaB-1fnsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 1fns VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 12 LEU A 519
LEU A 621
ALA A 623
SER A 679
LEU A 677
 None
 0.98A 5mwyA-1fnsA:
undetectable		 5mwyA-1fnsA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UNW_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1fns VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 PHE A 536
GLU A 542
MET A 541
VAL A 691
 None
 1.37A 5unwA-1fnsA:
0.4
5unwB-1fnsA:
0.0		 5unwA-1fnsA:
19.90
5unwB-1fnsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUI_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1fns VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 PHE A 536
GLU A 542
MET A 541
VAL A 691
 None
 1.29A 5vuiA-1fnsA:
0.5
5vuiB-1fnsA:
0.6		 5vuiA-1fnsA:
19.90
5vuiB-1fnsA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CID_A_H4BA802_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1fns VON WILLEBRAND
FACTOR
(Homo
sapiens) 		4 / 7 MET A 541
VAL A 691
PHE A 536
GLU A 542
 None
 1.37A 6cidA-1fnsA:
0.3
6cidB-1fnsA:
0.0		 6cidA-1fnsA:
16.58
6cidB-1fnsA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_C_SAMC301_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1fns VON WILLEBRAND
FACTOR
(Homo
sapiens) 		5 / 12 LEU A 619
THR A 594
ILE A 617
VAL A 646
ILE A 649
 None
 0.87A 6emuC-1fnsA:
1.3		 6emuC-1fnsA:
22.42