SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fnz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_D_DVAD8_0
(GRAMICIDIN A)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		3 / 3 TRP A 156
VAL A 163
TRP A 158
 None
 1.30A 1c4dC-1fnzA:
undetectable
1c4dD-1fnzA:
undetectable		 1c4dC-1fnzA:
4.64
1c4dD-1fnzA:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_B_EAAB224_1
(GLUTATHIONE
TRANSFERASE)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		5 / 12 GLY A  48
LEU A  32
VAL A 226
LEU A  89
ALA A  90
 None
 1.07A 1gseB-1fnzA:
undetectable		 1gseB-1fnzA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		4 / 7 THR A  85
ARG A 139
TYR A 183
LEU A 181
 None
 1.15A 1ibgL-1fnzA:
1.1		 1ibgL-1fnzA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_A_DVAA6_0
(GRAMICIDIN B)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		3 / 3 ALA A  54
VAL A 206
TRP A 205
 None
 0.92A 1jo3A-1fnzA:
undetectable		 1jo3A-1fnzA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO3_B_DVAB6_0
(GRAMICIDIN B)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		3 / 3 ALA A  54
VAL A 206
TRP A 205
 None
 0.92A 1jo3B-1fnzA:
undetectable		 1jo3B-1fnzA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_A_DVAA6_0
(GRAMICIDIN C)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		3 / 3 ALA A  54
VAL A 206
TRP A 205
 None
 0.89A 1jo4A-1fnzA:
undetectable		 1jo4A-1fnzA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JO4_B_DVAB6_0
(GRAMICIDIN C)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		3 / 3 ALA A  54
VAL A 206
TRP A 205
 None
 0.89A 1jo4B-1fnzA:
undetectable		 1jo4B-1fnzA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		5 / 12 ILE A 121
LEU A  51
LEU A 101
GLY A 108
PHE A 110
 None
 1.16A 1tsnA-1fnzA:
0.0		 1tsnA-1fnzA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1302_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		5 / 11 THR A 213
GLY A  48
GLY A 108
PHE A  92
ILE A 109
 None
 1.43A 2y7kA-1fnzA:
0.0		 2y7kA-1fnzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7P_A_SALA1000_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		5 / 10 THR A 213
GLY A  48
GLY A 108
PHE A  92
ILE A 109
 None
 1.43A 2y7pA-1fnzA:
undetectable		 2y7pA-1fnzA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		3 / 3 PHE A 210
TYR A  52
LEU A  47
 None
 0.76A 3sueB-1fnzA:
0.0		 3sueB-1fnzA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_A_D16A301_1
(THYMIDYLATE SYNTHASE)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		5 / 12 ILE A 121
LEU A  51
LEU A 101
GLY A 108
PHE A 110
 None
 1.18A 4foxA-1fnzA:
0.0		 4foxA-1fnzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_B_D16B302_1
(THYMIDYLATE SYNTHASE)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		5 / 12 ILE A 121
LEU A  51
LEU A 101
GLY A 108
PHE A 110
 None
 1.21A 4foxB-1fnzA:
0.0		 4foxB-1fnzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		5 / 12 ILE A 109
ALA A  94
ALA A  50
ILE A 168
THR A  98
 None
 1.05A 4psyA-1fnzA:
undetectable		 4psyA-1fnzA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		5 / 12 TYR A 220
GLU A 125
ASP A  87
ASP A 127
GLY A 138
 A2G  A 555 (-3.2A)
None
A2G  A 555 (-2.9A)
CA  A 500 (-2.2A)
None
 1.50A 4qb9E-1fnzA:
0.0		 4qb9E-1fnzA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_F_PARF500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		5 / 11 TYR A 220
GLU A 125
ASP A  87
ASP A 127
GLY A 138
 A2G  A 555 (-3.2A)
None
A2G  A 555 (-2.9A)
CA  A 500 (-2.2A)
None
 1.48A 4qb9F-1fnzA:
0.0		 4qb9F-1fnzA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		5 / 9 PHE A  11
LEU A  18
LEU A  89
THR A  74
PHE A  91
 None
 1.39A 4wnvB-1fnzA:
0.0		 4wnvB-1fnzA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		4 / 8 TYR A 170
ILE A 168
PHE A  56
LEU A 202
 None
 0.89A 5esfA-1fnzA:
0.0		 5esfA-1fnzA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		4 / 7 TYR A 170
PHE A 231
PHE A  56
LEU A 202
 None
 1.03A 5esmA-1fnzA:
undetectable		 5esmA-1fnzA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_G_ACTG702_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		3 / 3 GLY A  88
THR A 214
ASN A 224
 None
 0.71A 5odiG-1fnzA:
undetectable		 5odiG-1fnzA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		5 / 11 VAL A 166
LEU A  89
ALA A 179
GLN A 222
TYR A 183
 None
 1.22A 6dryA-1fnzA:
undetectable		 6dryA-1fnzA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_A_FFOA403_0
(THYMIDYLATE SYNTHASE)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		5 / 12 ILE A 121
LEU A  51
LEU A 101
GLY A 108
PHE A 110
 None
 1.13A 6r2eA-1fnzA:
0.0		 6r2eA-1fnzA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_G_FFOG403_0
(THYMIDYLATE SYNTHASE)		 1fnz BARK AGGLUTININ I,
POLYPEPTIDE A
(Robinia
pseudoacacia) 		5 / 11 ILE A 121
LEU A  51
LEU A 101
GLY A 108
PHE A 110
 None
 1.16A 6r2eG-1fnzA:
0.0		 6r2eG-1fnzA:
22.09