SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1foh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 8 LEU A 380
ALA A  18
GLY A  14
ILE A  40
PHE A 353
 None
FAD  A 801 (-3.3A)
FAD  A 801 (-3.1A)
None
None
 1.10A 1d4sB-1fohA:
0.0		 1d4sB-1fohA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_1
(PROTEIN (HIV-1
PROTEASE))		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 10 LEU A 235
ALA A 358
ASP A 357
GLY A  14
ILE A  12
 None
None
FAD  A 801 (-2.9A)
FAD  A 801 (-3.1A)
None
 0.97A 1d4yA-1fohA:
undetectable		 1d4yA-1fohA:
9.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
ILE A 279
ARG A 287
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 (-4.0A)
FAD  A 801 (-3.9A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.00A 1fohA-1fohA:
70.0		 1fohA-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_A_IPHA802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 10 GLY A 367
ARG A 287
ILE A 279
ARG A 265
GLY A  55
 IPH  A 802 (-3.7A)
FAD  A 801 (-3.9A)
IPH  A 802 (-4.0A)
IPH  A 802 (-3.6A)
IPH  A 802 ( 3.8A)
 1.24A 1fohA-1fohA:
70.0		 1fohA-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
ILE A 279
ARG A 287
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 (-4.0A)
FAD  A 801 (-3.9A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.00A 1fohB-1fohA:
68.1		 1fohB-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_B_IPHB802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 10 GLY A 367
ARG A 287
ILE A 279
ARG A 265
GLY A  55
 IPH  A 802 (-3.7A)
FAD  A 801 (-3.9A)
IPH  A 802 (-4.0A)
IPH  A 802 (-3.6A)
IPH  A 802 ( 3.8A)
 1.23A 1fohB-1fohA:
68.1		 1fohB-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
ILE A 279
ARG A 287
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 (-4.0A)
FAD  A 801 (-3.9A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.14A 1fohC-1fohA:
57.0		 1fohC-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_C_IPHC802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 10 GLY A 367
ARG A 287
ILE A 279
ARG A 265
GLY A  55
 IPH  A 802 (-3.7A)
FAD  A 801 (-3.9A)
IPH  A 802 (-4.0A)
IPH  A 802 (-3.6A)
IPH  A 802 ( 3.8A)
 1.24A 1fohC-1fohA:
57.0		 1fohC-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
ILE A 279
ARG A 287
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 (-4.0A)
FAD  A 801 (-3.9A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.18A 1fohD-1fohA:
57.1		 1fohD-1fohA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 10 GLY A 367
ARG A 287
ILE A 279
ARG A 265
GLY A  55
 IPH  A 802 (-3.7A)
FAD  A 801 (-3.9A)
IPH  A 802 (-4.0A)
IPH  A 802 (-3.6A)
IPH  A 802 ( 3.8A)
 1.26A 1fohD-1fohA:
57.1		 1fohD-1fohA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 12 PHE A 445
PHE A 418
LEU A 104
PHE A 414
GLY A 367
 None
None
None
None
IPH  A 802 (-3.7A)
 1.11A 1igxA-1fohA:
0.0		 1igxA-1fohA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PN0_A_IPHA6012_0
(PHENOL
2-MONOOXYGENASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
MET A 277
ILE A 279
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 ( 4.3A)
IPH  A 802 (-4.0A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.12A 1pn0A-1fohA:
66.8		 1pn0A-1fohA:
98.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PN0_B_IPHB6022_0
(PHENOL
2-MONOOXYGENASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
MET A 277
ILE A 279
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 ( 4.3A)
IPH  A 802 (-4.0A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.08A 1pn0B-1fohA:
66.5		 1pn0B-1fohA:
98.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PN0_C_IPHC6032_0
(PHENOL
2-MONOOXYGENASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
MET A 277
ILE A 279
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 ( 4.3A)
IPH  A 802 (-4.0A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.19A 1pn0C-1fohA:
56.6		 1pn0C-1fohA:
98.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PN0_D_IPHD6042_0
(PHENOL
2-MONOOXYGENASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		10 / 10 ASP A  54
GLY A  55
MET A  80
GLN A 112
VAL A 114
ARG A 265
MET A 277
ILE A 279
TYR A 289
GLY A 367
 IPH  A 802 (-2.9A)
IPH  A 802 ( 3.8A)
IPH  A 802 ( 4.8A)
IPH  A 802 (-3.8A)
None
IPH  A 802 (-3.6A)
IPH  A 802 ( 4.3A)
IPH  A 802 (-4.0A)
FAD  A 801 ( 4.6A)
IPH  A 802 (-3.7A)
 0.18A 1pn0D-1fohA:
56.6		 1pn0D-1fohA:
98.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 8 ALA A 358
ASP A 357
GLY A  14
ILE A  12
PRO A 144
 None
FAD  A 801 (-2.9A)
FAD  A 801 (-3.1A)
None
FAD  A 801 (-4.3A)
 1.38A 1sh9A-1fohA:
undetectable		 1sh9A-1fohA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 5 ALA A 366
PHE A 418
ILE A  83
ASP A 102
 None
 0.88A 1yc2D-1fohA:
2.4		 1yc2D-1fohA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		3 / 3 ARG A 394
VAL A 464
THR A 399
 None
 0.64A 2nmzA-1fohA:
0.0		 2nmzA-1fohA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		3 / 3 ARG A 394
VAL A 464
THR A 399
 None
 0.68A 2nnkA-1fohA:
0.0		 2nnkA-1fohA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		3 / 3 ARG A 109
ASN A 449
THR A 455
 None
 0.76A 2q63A-1fohA:
0.0		 2q63A-1fohA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_A_QPSA1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 12 THR A 372
PHE A 414
GLY A 454
ALA A 452
GLN A 368
 None
 1.21A 2x2iA-1fohA:
0.0		 2x2iA-1fohA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 10 THR A 372
PHE A 414
GLY A 454
ALA A 452
GLN A 368
 None
 1.19A 2x2iB-1fohA:
0.6		 2x2iB-1fohA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 8 VAL A 514
SER A 469
VAL A 541
VAL A 617
 None
 0.97A 2y05A-1fohA:
undetectable
2y05B-1fohA:
undetectable		 2y05A-1fohA:
18.20
2y05B-1fohA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 11 PHE A 325
ILE A 262
PHE A 320
PHE A 288
LEU A 330
 None
 1.35A 3a9eB-1fohA:
0.0		 3a9eB-1fohA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BU1_A_HSMA301_1
(LIPOCALIN)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 7 SER A 419
TYR A 336
ILE A 338
ASP A 415
 None
 1.13A 3bu1A-1fohA:
undetectable		 3bu1A-1fohA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 12 VAL A 250
TYR A 336
ILE A 120
HIS A 116
ARG A 119
 FAD  A 801 ( 4.8A)
None
None
None
None
 1.36A 3bwyA-1fohA:
4.1		 3bwyA-1fohA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_1
(PROTEASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 9 LEU A 235
ALA A 358
ASP A 357
GLY A  14
ILE A  12
 None
None
FAD  A 801 (-2.9A)
FAD  A 801 (-3.1A)
None
 1.02A 3ektA-1fohA:
undetectable		 3ektA-1fohA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 7 GLY A 118
GLN A  52
VAL A  48
ILE A 124
 None
FAD  A 801 ( 3.8A)
None
None
 0.93A 3fi0P-1fohA:
undetectable		 3fi0P-1fohA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_B_TMQB612_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 9 VAL A 558
ALA A 578
THR A 546
SER A 651
ILE A 556
 None
 1.47A 3hbbB-1fohA:
undetectable		 3hbbB-1fohA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW2_A_017A401_1
(GAG-POL POLYPROTEIN)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		6 / 12 GLY A 356
ALA A 358
GLY A  14
ILE A  12
VAL A 352
ILE A 354
 FAD  A 801 (-3.4A)
None
FAD  A 801 (-3.1A)
None
None
None
 1.48A 3jw2A-1fohA:
undetectable		 3jw2A-1fohA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_B_THHB643_0
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 12 ASN A 449
GLY A 448
ASP A 102
VAL A 114
GLY A 367
 None
None
None
None
IPH  A 802 (-3.7A)
 1.27A 3k13B-1fohA:
undetectable		 3k13B-1fohA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		3 / 3 ARG A 394
VAL A 464
THR A 399
 None
 0.73A 3k4vA-1fohA:
0.0		 3k4vA-1fohA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 6 ARG A 420
SER A 419
GLY A 241
GLU A 344
 None
 0.79A 3k9fA-1fohA:
0.0
3k9fB-1fohA:
0.0
3k9fD-1fohA:
undetectable		 3k9fA-1fohA:
22.65
3k9fB-1fohA:
22.65
3k9fD-1fohA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_2
(PROTEASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		3 / 3 ARG A 394
VAL A 464
THR A 399
 None
 0.62A 3ndtA-1fohA:
0.0		 3ndtA-1fohA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_3
(PROTEASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		3 / 3 ARG A 394
VAL A 464
THR A 399
 None
 0.75A 3nduD-1fohA:
0.0		 3nduD-1fohA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 7 PHE A 531
VAL A 558
ILE A 512
SER A 543
 None
 0.98A 3pglA-1fohA:
3.1		 3pglA-1fohA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 12 ILE A 131
ILE A 559
ASP A 557
ARG A 509
ASP A 507
 None
 1.31A 3phaB-1fohA:
undetectable		 3phaB-1fohA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		3 / 3 ARG A 394
VAL A 464
THR A 399
 None
 0.67A 3pwrA-1fohA:
0.0		 3pwrA-1fohA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		3 / 4 SER A 419
GLY A 241
GLU A 344
 None
 0.47A 3raeA-1fohA:
0.0
3raeC-1fohA:
0.2		 3raeA-1fohA:
22.65
3raeC-1fohA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 12 VAL A 617
ILE A 528
LEU A 535
VAL A 541
TYR A 603
 None
 1.24A 3sp9B-1fohA:
0.0		 3sp9B-1fohA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		3 / 3 ARG A 394
VAL A 464
THR A 399
 None
 0.68A 3tl9A-1fohA:
0.0		 3tl9A-1fohA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 6 HIS A 172
ASP A 171
SER A  45
PRO A 176
 None
 1.26A 4apjA-1fohA:
0.0
4apjP-1fohA:
undetectable		 4apjA-1fohA:
21.72
4apjP-1fohA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DPR_A_X8ZA702_1
(LEUKOTRIENE A-4
HYDROLASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 9 TYR A 168
GLY A 211
GLU A 173
GLU A 145
LYS A   1
 None
 1.48A 4dprA-1fohA:
undetectable		 4dprA-1fohA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_A_CCSA109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 8 VAL A 489
HIS A 562
ILE A 561
ALA A 519
 None
 0.96A 4eyzA-1fohA:
0.0		 4eyzA-1fohA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 8 VAL A 489
HIS A 562
ILE A 561
ALA A 519
 None
 0.97A 4eyzB-1fohA:
0.0		 4eyzB-1fohA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_B_STRB301_1
(STEROID RECEPTOR 2)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 12 LEU A  67
LEU A  64
LEU A  61
MET A  21
THR A 506
 None
 1.19A 4fn9B-1fohA:
undetectable		 4fn9B-1fohA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JUO_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		3 / 4 SER A 419
GLY A 241
GLU A 344
 None
 0.50A 4juoA-1fohA:
undetectable
4juoC-1fohA:
undetectable		 4juoA-1fohA:
22.65
4juoC-1fohA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 8 ASN A  78
ARG A 281
ASP A 102
ILE A  83
 None
 0.84A 4k0bA-1fohA:
0.0		 4k0bA-1fohA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 8 ASN A  78
ARG A 281
ASP A 102
ILE A  83
 None
 0.77A 4l7iA-1fohA:
0.0		 4l7iA-1fohA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		3 / 3 HIS A 416
VAL A 440
LEU A 421
 None
 0.77A 4m2vA-1fohA:
0.0		 4m2vA-1fohA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 5 ARG A  59
TYR A 623
THR A 506
VAL A  25
 None
 1.46A 4mjqA-1fohA:
0.6		 4mjqA-1fohA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 4 ILE A 457
ASP A 376
ARG A 619
THR A 372
 None
 1.50A 4nx6A-1fohA:
undetectable		 4nx6A-1fohA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_1
(DIHYDROFOLATE
REDUCTASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 4 ILE A 457
ASP A 376
ARG A 619
THR A 372
 None
 1.49A 4nx7A-1fohA:
undetectable		 4nx7A-1fohA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 9 ALA A 578
ILE A 513
VAL A 617
THR A 633
SER A 540
 None
 1.29A 4r20B-1fohA:
undetectable		 4r20B-1fohA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 8 ARG A  31
ARG A  24
VAL A  25
ASP A 507
 None
 1.04A 4xqgA-1fohA:
4.3		 4xqgA-1fohA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQG_B_AG2B505_1
(HOMOSPERMIDINE
SYNTHASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 8 ARG A  31
ARG A  24
VAL A  25
ASP A 507
 None
 1.04A 4xqgB-1fohA:
undetectable		 4xqgB-1fohA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 7 GLU A 139
ILE A  12
LEU A  67
ILE A 128
 None
 0.94A 4xumA-1fohA:
0.0		 4xumA-1fohA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_3
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 12 ARG A  44
VAL A  13
ILE A  12
LEU A 125
ILE A 128
 FAD  A 801 (-3.2A)
FAD  A 801 (-4.8A)
None
None
None
 1.18A 5b8iC-1fohA:
undetectable		 5b8iC-1fohA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		3 / 3 ILE A 100
PRO A 101
ILE A  83
 None
 0.30A 5hw8F-1fohA:
0.3		 5hw8F-1fohA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 12 GLU A 282
LEU A  20
ARG A 281
GLY A  55
LEU A  56
 None
None
None
IPH  A 802 ( 3.8A)
None
 1.28A 5m50E-1fohA:
undetectable		 5m50E-1fohA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MXB_A_ML1A222_1
(CLASS 10 PLANT
PATHOGENESIS-RELATED
PROTEIN)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 10 VAL A 616
ILE A 513
ARG A 511
GLY A 622
PHE A 484
 None
 1.15A 5mxbA-1fohA:
1.0		 5mxbA-1fohA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 8 VAL A 138
THR A 377
ALA A  18
LEU A  20
 None
None
FAD  A 801 (-3.3A)
None
 0.77A 5og9A-1fohA:
0.9		 5og9A-1fohA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 10 TYR A 378
ILE A  12
ILE A  41
LEU A 142
ILE A 128
 None
 1.43A 5vkqA-1fohA:
0.0
5vkqD-1fohA:
0.0		 5vkqA-1fohA:
18.01
5vkqD-1fohA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1808_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 10 ILE A 128
TYR A 378
ILE A  12
ILE A  41
LEU A 142
 None
 1.42A 5vkqA-1fohA:
0.0
5vkqB-1fohA:
0.0		 5vkqA-1fohA:
18.01
5vkqB-1fohA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 10 ILE A 128
TYR A 378
ILE A  12
ILE A  41
LEU A 142
 None
 1.41A 5vkqC-1fohA:
0.0
5vkqD-1fohA:
0.0		 5vkqC-1fohA:
18.01
5vkqD-1fohA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		4 / 6 PHE A 414
LEU A 411
ALA A 452
GLN A 409
 None
 0.92A 6b89B-1fohA:
undetectable		 6b89B-1fohA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_1
(-)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 12 THR A  60
ASP A 376
HIS A 360
LEU A 411
GLY A 454
 None
 1.33A 6f3mA-1fohA:
0.0		 6f3mA-1fohA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_1
(-)		 1foh PHENOL HYDROXYLASE
(Cutaneotrichospo
ron
cutaneum) 		5 / 12 THR A  60
ASP A 376
HIS A 360
LEU A 411
GLY A 454
 None
 1.32A 6f3mC-1fohA:
1.6		 6f3mC-1fohA:
23.02