SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fok'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H1D_A_SAMA301_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 12 MET A 433
GLY A 451
TYR A 436
TYR A 454
HIS A 442
 None
 1.37A 1h1dA-1fokA:
undetectable		 1h1dA-1fokA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		4 / 7 PHE A 129
TYR A 122
THR A  67
VAL A  72
 None
 0.98A 1p7rA-1fokA:
0.0		 1p7rA-1fokA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC339_0
(ADP-RIBOSYL CYCLASE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		3 / 3 GLU A 214
ASN A 218
TRP A 219
 None
 0.94A 1r15C-1fokA:
3.5		 1r15C-1fokA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_D_NCAD349_0
(ADP-RIBOSYL CYCLASE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		3 / 3 GLU A 214
ASN A 218
TRP A 219
 None
 0.95A 1r15D-1fokA:
2.9		 1r15D-1fokA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_E_NCAE359_0
(ADP-RIBOSYL CYCLASE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		3 / 3 GLU A 214
ASN A 218
TRP A 219
 None
 0.94A 1r15E-1fokA:
3.3		 1r15E-1fokA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF369_0
(ADP-RIBOSYL CYCLASE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		3 / 3 GLU A 214
ASN A 218
TRP A 219
 None
 0.94A 1r15F-1fokA:
2.8		 1r15F-1fokA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		4 / 8 LEU A 168
ALA A 227
ILE A 230
GLY A 185
 None
 0.84A 1sv9A-1fokA:
undetectable		 1sv9A-1fokA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA602_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		4 / 8 ILE A  87
PHE A  27
LEU A  64
ILE A  65
 None
 0.80A 2azxA-1fokA:
undetectable		 2azxA-1fokA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_A_SAMA1217_0
(CATECHOL
O-METHYLTRANSFERASE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 12 MET A 433
GLY A 451
TYR A 436
TYR A 454
HIS A 442
 None
 1.40A 2cl5A-1fokA:
0.0		 2cl5A-1fokA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		4 / 6 LEU A 565
GLU A 514
ILE A 460
PRO A 459
 None
 0.90A 2fcnA-1fokA:
undetectable
2fcnB-1fokA:
undetectable		 2fcnA-1fokA:
9.14
2fcnB-1fokA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		4 / 7 TYR A 462
GLY A 457
THR A 455
TYR A 438
 None
 0.96A 2g70A-1fokA:
undetectable		 2g70A-1fokA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		4 / 7 TYR A 462
GLY A 457
THR A 455
TYR A 438
 None
 0.97A 2g70B-1fokA:
undetectable		 2g70B-1fokA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		4 / 6 THR A 298
ARG A 307
ASN A 104
ASP A 103
 None
 1.19A 2okcA-1fokA:
undetectable		 2okcA-1fokA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		4 / 6 ILE A 352
ARG A 310
ARG A 309
ILE A 344
 None
 0.95A 2q72A-1fokA:
0.0		 2q72A-1fokA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		3 / 3 ASN A 502
ARG A 447
ASP A 467
 None
 0.98A 2qe6A-1fokA:
undetectable		 2qe6A-1fokA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		3 / 3 ASN A 502
ARG A 447
ASP A 467
 None
 0.95A 2qe6B-1fokA:
undetectable		 2qe6B-1fokA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 12 TYR A 438
PHE A 572
VAL A 464
PHE A 431
TYR A 436
 None
 1.27A 3apwA-1fokA:
0.2		 3apwA-1fokA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 12 ILE A 423
LEU A 424
LEU A 411
THR A 203
VAL A 428
 None
 1.22A 3dcjA-1fokA:
undetectable
3dcjB-1fokA:
undetectable		 3dcjA-1fokA:
16.93
3dcjB-1fokA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 12 THR A 301
SER A 472
ILE A 412
ASP A 302
LEU A 390
 None
 1.13A 3iv6D-1fokA:
undetectable		 3iv6D-1fokA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 7 GLN A 420
SER A 190
LEU A 552
ARG A 416
ILE A 414
 None
 1.47A 3ln1C-1fokA:
0.0		 3ln1C-1fokA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		4 / 4 VAL A 568
PHE A 572
PHE A 515
VAL A 512
 None
 1.46A 3rv5C-1fokA:
1.0
3rv5D-1fokA:
1.3		 3rv5C-1fokA:
13.53
3rv5D-1fokA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		4 / 6 VAL A 520
PHE A 432
VAL A 464
PHE A 579
 None
 1.04A 3soaA-1fokA:
0.0		 3soaA-1fokA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 9 ILE A 313
LEU A 317
ILE A 358
ILE A 356
ILE A 352
 None
 1.02A 3zosA-1fokA:
undetectable		 3zosA-1fokA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		4 / 8 ILE A 465
GLY A 444
ASN A 502
GLU A 425
 None
 0.91A 4fgjA-1fokA:
2.5
4fgjB-1fokA:
3.0		 4fgjA-1fokA:
18.06
4fgjB-1fokA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 11 LEU A 551
VAL A 435
ILE A 558
PHE A 432
LEU A 565
 None
 1.42A 4lhmA-1fokA:
undetectable		 4lhmA-1fokA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 12 ILE A 453
ILE A 558
PHE A 432
LEU A 546
TYR A 462
 None
 0.94A 4m2xA-1fokA:
undetectable		 4m2xA-1fokA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKT_A_198A1001_1
(ANDROGEN RECEPTOR)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 12 LEU A 443
GLY A 444
MET A 433
THR A 203
ILE A 215
 None
 1.30A 4oktA-1fokA:
undetectable		 4oktA-1fokA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_H_377H401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		4 / 6 ASN A 573
GLU A 576
GLU A 550
PHE A 579
 None
 1.47A 4twdG-1fokA:
undetectable
4twdH-1fokA:
undetectable		 4twdG-1fokA:
19.32
4twdH-1fokA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_J_377J401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		4 / 6 GLU A 339
TYR A 305
LEU A 385
PHE A 337
 None
 0.88A 4twdI-1fokA:
undetectable
4twdJ-1fokA:
0.0		 4twdI-1fokA:
19.32
4twdJ-1fokA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FEP_A_SAMA407_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 12 TYR A  66
GLN A  25
SER A 139
GLY A 135
LEU A 136
 None
 1.45A 5fepA-1fokA:
undetectable		 5fepA-1fokA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FES_A_SAMA408_0
([FEFE] HYDROGENASE
MATURASE SUBUNIT
HYDE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 12 TYR A  66
GLN A  25
SER A 139
GLY A 135
LEU A 136
 None
 1.48A 5fesA-1fokA:
undetectable		 5fesA-1fokA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 12 MET A 433
GLY A 451
TYR A 436
TYR A 454
HIS A 442
 None
 1.37A 5fhrB-1fokA:
1.4		 5fhrB-1fokA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 10 ILE A 267
LEU A 275
ALA A 162
ILE A 163
ILE A 230
 None
 0.94A 5mvmD-1fokA:
undetectable
5mvmE-1fokA:
0.0		 5mvmD-1fokA:
11.04
5mvmE-1fokA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		4 / 8 ASN A  13
PRO A  14
PHE A 110
TYR A  68
 None
 1.24A 5oh1C-1fokA:
0.0		 5oh1C-1fokA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		3 / 3 TYR A 305
ALA A 311
LEU A 312
 None
 0.61A 6ag0C-1fokA:
undetectable		 6ag0C-1fokA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 12 VAL A 548
ILE A 453
VAL A 464
VAL A 428
PHE A 432
 None
 1.22A 6ap6A-1fokA:
undetectable		 6ap6A-1fokA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 12 VAL A 548
ILE A 453
VAL A 464
VAL A 428
PHE A 432
 None
 1.23A 6ap6B-1fokA:
undetectable		 6ap6B-1fokA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		4 / 5 THR A 468
THR A 193
GLN A 420
ASP A 224
 None
 1.43A 6ecxA-1fokA:
undetectable		 6ecxA-1fokA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_H_FFOH403_0
(THYMIDYLATE SYNTHASE)		 1fok PROTEIN (FOKI
RESTRICTION
ENDONUCLEASE)
(Planomicrobium
okeanokoites) 		5 / 12 PHE A 119
TYR A 226
ASP A 108
LEU A 111
GLY A 109
 None
 1.28A 6r2eH-1fokA:
0.8		 6r2eH-1fokA:
19.58