SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fot'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_E_ESTE600_1
(ESTROGEN RECEPTOR)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 192
GLU A 193
LEU A 349
LEU A 350
 None
 0.96A 1ereE-1fotA:
undetectable		 1ereE-1fotA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERE_F_ESTF600_1
(ESTROGEN RECEPTOR)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		4 / 8 ALA A 192
GLU A 193
LEU A 349
LEU A 350
 None
 0.98A 1ereF-1fotA:
undetectable		 1ereF-1fotA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 272
LEU A 172
LEU A 196
ALA A 197
PHE A 189
 None
 1.20A 1g5yB-1fotA:
undetectable		 1g5yB-1fotA:
19.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		5 / 9 LEU A  93
GLY A  94
VAL A 101
ALA A 114
TYR A 166
 None
 0.43A 1muoA-1fotA:
23.2		 1muoA-1fotA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 218
GLY A 222
HIS A 223
ILE A 224
 None
 0.88A 1xf1A-1fotA:
undetectable		 1xf1A-1fotA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 101
ALA A 114
GLU A 135
LEU A 139
ILE A 148
 None
 0.89A 3gcsA-1fotA:
22.6		 3gcsA-1fotA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GCS_A_BAXA401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		5 / 12 VAL A 101
ALA A 114
LEU A 139
ILE A 148
ASP A 228
 None
 1.00A 3gcsA-1fotA:
22.6		 3gcsA-1fotA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 147
ILE A 148
MET A 162
TYR A 166
ILE A 226
 None
 0.63A 3zosA-1fotA:
21.3		 3zosA-1fotA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		7 / 12 VAL A 101
ALA A 114
ILE A 148
MET A 162
TYR A 166
LEU A 217
ASP A 228
 None
 1.02A 4bkjA-1fotA:
21.2		 4bkjA-1fotA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CKI_A_ADNA2022_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		6 / 11 LEU A  93
GLY A  94
GLY A  96
VAL A 101
ALA A 114
TYR A 166
 None
 0.62A 4ckiA-1fotA:
24.0		 4ckiA-1fotA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 396
ARG A 395
ASP A 134
 None
 0.65A 4fp9A-1fotA:
undetectable		 4fp9A-1fotA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 396
ARG A 395
ASP A 134
 None
 0.71A 4fp9C-1fotA:
undetectable		 4fp9C-1fotA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		3 / 3 ASP A 396
ARG A 395
ASP A 134
 None
 0.74A 4fp9F-1fotA:
undetectable		 4fp9F-1fotA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 167
TYR A 190
VAL A 186
LEU A 218
LEU A 349
 None
 1.31A 4qynA-1fotA:
undetectable		 4qynA-1fotA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WBO_C_ANWC601_0
(RHODOPSIN KINASE)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		5 / 6 ARG A  91
LEU A  93
ALA A 114
MET A 164
LEU A 217
 None
 0.92A 4wboC-1fotA:
33.6		 4wboC-1fotA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		5 / 6 CYH A 195
GLU A 333
GLY A 331
GLY A 326
ASP A 334
 None
 1.42A 5a06D-1fotA:
undetectable		 5a06D-1fotA:
22.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		5 / 7 GLY A  94
GLY A  96
SER A  97
PHE A  98
LEU A 118
 None
 1.16A 5izfA-1fotA:
38.8		 5izfA-1fotA:
45.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		4 / 7 GLY A  94
SER A  97
LYS A 116
LEU A 118
 None
 0.80A 5izfA-1fotA:
38.8		 5izfA-1fotA:
45.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IZJ_F_AZ1F2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR-DAR)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		5 / 7 GLY A  94
GLY A  96
SER A  97
GLY A  99
LEU A 118
 None
 0.83A 5izjB-1fotA:
39.6		 5izjB-1fotA:
45.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		4 / 5 ILE A 216
LEU A 316
GLY A 269
PHE A 268
 None
 0.91A 5kmdC-1fotA:
2.6
5kmdD-1fotA:
1.8		 5kmdC-1fotA:
20.66
5kmdD-1fotA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_A_ECLA1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 317
PHE A 305
LEU A 313
ALA A 187
 None
 0.81A 6b5vA-1fotA:
undetectable
6b5vC-1fotA:
undetectable		 6b5vA-1fotA:
13.31
6b5vC-1fotA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 187
ILE A 317
PHE A 305
LEU A 313
 None
 0.77A 6b5vA-1fotA:
0.0
6b5vB-1fotA:
0.0		 6b5vA-1fotA:
13.31
6b5vB-1fotA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_C_ECLC1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		4 / 7 ILE A 317
PHE A 305
LEU A 313
ALA A 187
 None
 0.82A 6b5vC-1fotA:
undetectable
6b5vD-1fotA:
undetectable		 6b5vC-1fotA:
13.31
6b5vD-1fotA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_D_ECLD1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1fot CAMP-DEPENDENT
PROTEIN KINASE TYPE
1
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 187
ILE A 317
PHE A 305
LEU A 313
 None
 0.82A 6b5vB-1fotA:
0.0
6b5vD-1fotA:
undetectable		 6b5vB-1fotA:
13.31
6b5vD-1fotA:
13.31