SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fpq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		4 / 7 ILE A 308
TYR A 343
PHE A 355
PHE A 370
 None
 1.24A 1e71M-1fpqA:
undetectable		 1e71M-1fpqA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		4 / 7 ILE A 308
TYR A 343
PHE A 355
PHE A 370
 None
 1.25A 1e72M-1fpqA:
undetectable		 1e72M-1fpqA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		4 / 8 MET A 189
PHE A 185
THR A 332
LEU A 328
 SAM  A1699 ( 4.2A)
None
None
None
 1.01A 1ea1A-1fpqA:
undetectable		 1ea1A-1fpqA:
22.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		10 / 10 CYH A 193
GLY A 217
ASN A 223
ASP A 240
LEU A 241
VAL A 244
ASP A 260
ALA A 275
ASN A 279
TRP A 280
 SAM  A1699 ( 3.7A)
SAM  A1699 (-3.6A)
SAM  A1699 (-4.1A)
SAM  A1699 (-2.9A)
SAM  A1699 (-4.2A)
SAM  A1699 (-4.7A)
SAM  A1699 (-3.8A)
SAM  A1699 (-3.5A)
SAM  A1699 (-4.0A)
None
 0.00A 1fpqA-1fpqA:
51.8		 1fpqA-1fpqA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		5 / 10 GLY A 218
ASP A 240
LEU A 241
VAL A 244
ALA A 275
 None
SAM  A1699 (-2.9A)
SAM  A1699 (-4.2A)
SAM  A1699 (-4.7A)
SAM  A1699 (-3.5A)
 1.13A 1fpqA-1fpqA:
51.8		 1fpqA-1fpqA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		5 / 11 LEU A 201
ILE A 303
GLU A 196
LYS A 274
ILE A 272
 None
None
None
SAM  A1699 (-4.4A)
None
 1.28A 1gx9A-1fpqA:
0.0		 1gx9A-1fpqA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		3 / 3 CYH A 277
ARG A 338
CYH A 285
 None
 1.41A 1p9gA-1fpqA:
undetectable		 1p9gA-1fpqA:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		4 / 8 ASP A 215
GLY A 218
GLY A 221
LEU A 224
 None
 0.36A 1qzzA-1fpqA:
21.3		 1qzzA-1fpqA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		7 / 12 GLY A 217
GLY A 218
GLY A 219
LEU A 241
ASP A 260
ASN A 279
TRP A 280
 SAM  A1699 (-3.6A)
None
None
SAM  A1699 (-4.2A)
SAM  A1699 (-3.8A)
SAM  A1699 (-4.0A)
None
 0.53A 1qzzA-1fpqA:
10.0		 1qzzA-1fpqA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		4 / 5 LEU A 321
ALA A  28
LEU A  26
SER A  23
 None
 1.13A 1tt6B-1fpqA:
0.0		 1tt6B-1fpqA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		7 / 12 GLY A 217
GLY A 218
GLY A 219
LEU A 241
ASP A 260
ASN A 279
TRP A 280
 SAM  A1699 (-3.6A)
None
None
SAM  A1699 (-4.2A)
SAM  A1699 (-3.8A)
SAM  A1699 (-4.0A)
None
 0.42A 1xdsA-1fpqA:
12.7		 1xdsA-1fpqA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		7 / 12 GLY A 217
GLY A 218
GLY A 219
LEU A 241
ASP A 260
ASN A 279
TRP A 280
 SAM  A1699 (-3.6A)
None
None
SAM  A1699 (-4.2A)
SAM  A1699 (-3.8A)
SAM  A1699 (-4.0A)
None
 0.45A 1xdsB-1fpqA:
20.4		 1xdsB-1fpqA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		5 / 12 GLY A 217
GLY A 219
GLY A 221
LEU A 241
VAL A 276
 SAM  A1699 (-3.6A)
None
None
SAM  A1699 (-4.2A)
SAM  A1699 ( 4.7A)
 0.86A 2oxtB-1fpqA:
8.5		 2oxtB-1fpqA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		5 / 12 ASP A 215
GLY A 217
GLY A 219
LEU A 241
VAL A 276
 None
SAM  A1699 (-3.6A)
None
SAM  A1699 (-4.2A)
SAM  A1699 ( 4.7A)
 0.74A 2oxtD-1fpqA:
7.8		 2oxtD-1fpqA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UYQ_A_SAMA1311_0
(HYPOTHETICAL PROTEIN
ML2640)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		4 / 7 GLY A 219
ASP A 240
VAL A 244
ASP A 260
 None
SAM  A1699 (-2.9A)
SAM  A1699 (-4.7A)
SAM  A1699 (-3.8A)
 0.60A 2uyqA-1fpqA:
11.2		 2uyqA-1fpqA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		3 / 3 ASN A 279
MET A 271
PHE A 288
 SAM  A1699 (-4.0A)
None
None
 0.98A 3g4lD-1fpqA:
undetectable		 3g4lD-1fpqA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		5 / 12 GLY A 218
GLY A 219
LEU A 241
ALA A 275
TRP A 280
 None
None
SAM  A1699 (-4.2A)
SAM  A1699 (-3.5A)
None
 0.32A 3i5uA-1fpqA:
14.8		 3i5uA-1fpqA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		5 / 12 GLY A 218
GLY A 219
LEU A 241
ALA A 275
TRP A 280
 None
None
SAM  A1699 (-4.2A)
SAM  A1699 (-3.5A)
None
 0.28A 3i5uB-1fpqA:
14.5		 3i5uB-1fpqA:
27.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		5 / 11 LEU A  49
PHE A  50
ALA A 133
THR A 137
ALA A  43
 None
 1.11A 3mdtB-1fpqA:
undetectable		 3mdtB-1fpqA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		3 / 3 GLY A 219
ASP A 240
ASP A 260
 None
SAM  A1699 (-2.9A)
SAM  A1699 (-3.8A)
 0.37A 3ou7C-1fpqA:
15.5		 3ou7C-1fpqA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_0
(2'-O-METHYL
TRANSFERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		5 / 12 ASN A 223
GLY A 217
SER A 220
LEU A 241
ASP A 260
 SAM  A1699 (-4.1A)
SAM  A1699 (-3.6A)
None
SAM  A1699 (-4.2A)
SAM  A1699 (-3.8A)
 1.49A 3r24A-1fpqA:
8.0		 3r24A-1fpqA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_1
(HIV-1 PROTEASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		5 / 11 LEU A 273
ALA A 270
ILE A 234
GLY A 236
ILE A 237
 None
 1.15A 3spkA-1fpqA:
undetectable		 3spkA-1fpqA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		4 / 4 ASN A  42
SER A  94
LEU A  91
THR A 136
 None
 1.32A 4an2A-1fpqA:
0.7		 4an2A-1fpqA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HTF_A_SAMA301_0
(S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		5 / 12 GLY A 219
GLY A 218
GLY A 217
HIS A 256
VAL A 244
 None
None
SAM  A1699 (-3.6A)
None
SAM  A1699 (-4.7A)
 0.87A 4htfA-1fpqA:
13.8		 4htfA-1fpqA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		4 / 4 LYS A 320
LEU A 321
GLU A 317
LEU A  26
 None
 1.44A 4k4yE-1fpqA:
0.0		 4k4yE-1fpqA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		5 / 11 PHE A  50
GLY A 115
ALA A  93
GLY A 120
LEU A 145
 None
 1.09A 4kt0A-1fpqA:
undetectable
4kt0J-1fpqA:
0.0		 4kt0A-1fpqA:
19.61
4kt0J-1fpqA:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		5 / 12 GLY A 217
GLY A 219
ASP A 240
LEU A 241
ALA A 275
 SAM  A1699 (-3.6A)
None
SAM  A1699 (-2.9A)
SAM  A1699 (-4.2A)
SAM  A1699 (-3.5A)
 1.12A 4lg1A-1fpqA:
11.7		 4lg1A-1fpqA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		5 / 12 GLY A 217
GLY A 219
ASP A 240
LEU A 241
ALA A 275
 SAM  A1699 (-3.6A)
None
SAM  A1699 (-2.9A)
SAM  A1699 (-4.2A)
SAM  A1699 (-3.5A)
 1.14A 4lg1C-1fpqA:
11.6		 4lg1C-1fpqA:
21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		8 / 11 GLY A 217
GLY A 218
ASP A 240
LEU A 241
VAL A 244
ASP A 260
MET A 261
LYS A 274
 SAM  A1699 (-3.6A)
None
SAM  A1699 (-2.9A)
SAM  A1699 (-4.2A)
SAM  A1699 (-4.7A)
SAM  A1699 (-3.8A)
SAM  A1699 (-3.9A)
SAM  A1699 (-4.4A)
 0.57A 4pghA-1fpqA:
13.5		 4pghA-1fpqA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_A_SAMA401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		5 / 11 GLY A 219
ASP A 240
LEU A 241
ASP A 260
MET A 261
 None
SAM  A1699 (-2.9A)
SAM  A1699 (-4.2A)
SAM  A1699 (-3.8A)
SAM  A1699 (-3.9A)
 1.12A 4pghA-1fpqA:
13.5		 4pghA-1fpqA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		7 / 12 ASP A 215
GLY A 217
ASP A 240
LEU A 241
ASP A 260
MET A 261
TRP A 280
 None
SAM  A1699 (-3.6A)
SAM  A1699 (-2.9A)
SAM  A1699 (-4.2A)
SAM  A1699 (-3.8A)
SAM  A1699 (-3.9A)
None
 0.46A 4pghB-1fpqA:
12.5		 4pghB-1fpqA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		7 / 12 GLY A 217
ASP A 240
LEU A 241
ASP A 260
MET A 261
LYS A 274
TRP A 280
 SAM  A1699 (-3.6A)
SAM  A1699 (-2.9A)
SAM  A1699 (-4.2A)
SAM  A1699 (-3.8A)
SAM  A1699 (-3.9A)
SAM  A1699 (-4.4A)
None
 0.59A 4pghB-1fpqA:
12.5		 4pghB-1fpqA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_C_SAMC401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		8 / 11 GLY A 217
ASP A 240
LEU A 241
VAL A 244
ASP A 260
MET A 261
LYS A 274
TRP A 280
 SAM  A1699 (-3.6A)
SAM  A1699 (-2.9A)
SAM  A1699 (-4.2A)
SAM  A1699 (-4.7A)
SAM  A1699 (-3.8A)
SAM  A1699 (-3.9A)
SAM  A1699 (-4.4A)
None
 0.55A 4pghC-1fpqA:
28.3		 4pghC-1fpqA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		7 / 12 GLY A 217
GLY A 218
ASP A 240
LEU A 241
ASP A 260
PHE A 262
LYS A 274
 SAM  A1699 (-3.6A)
None
SAM  A1699 (-2.9A)
SAM  A1699 (-4.2A)
SAM  A1699 (-3.8A)
SAM  A1699 (-4.4A)
SAM  A1699 (-4.4A)
 0.97A 4pghD-1fpqA:
25.1		 4pghD-1fpqA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		8 / 12 GLY A 217
GLY A 218
ASP A 240
LEU A 241
MET A 261
PHE A 262
LYS A 274
TRP A 280
 SAM  A1699 (-3.6A)
None
SAM  A1699 (-2.9A)
SAM  A1699 (-4.2A)
SAM  A1699 (-3.9A)
SAM  A1699 (-4.4A)
SAM  A1699 (-4.4A)
None
 0.84A 4pghD-1fpqA:
25.1		 4pghD-1fpqA:
38.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		6 / 12 GLY A 219
ASP A 240
LEU A 241
MET A 261
PHE A 262
TRP A 280
 None
SAM  A1699 (-2.9A)
SAM  A1699 (-4.2A)
SAM  A1699 (-3.9A)
SAM  A1699 (-4.4A)
None
 1.05A 4pghD-1fpqA:
25.1		 4pghD-1fpqA:
38.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		4 / 7 GLY A 217
GLY A 219
SER A 220
ASP A 260
 SAM  A1699 (-3.6A)
None
None
SAM  A1699 (-3.8A)
 0.70A 5ergB-1fpqA:
10.2		 5ergB-1fpqA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_C_ACTC1740_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGS
FAD-BINDING SUBUNIT)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		4 / 4 VAL A 305
GLU A 306
GLY A 366
LEU A 365
 None
 1.16A 5g5gC-1fpqA:
0.0		 5g5gC-1fpqA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		3 / 3 ARG A  90
PRO A 310
ASN A 314
 None
 0.96A 5jwaA-1fpqA:
2.7
5jwaH-1fpqA:
2.7		 5jwaA-1fpqA:
21.02
5jwaH-1fpqA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		3 / 3 TRP A 148
MET A 149
ASN A 150
 None
 0.93A 5uc1B-1fpqA:
0.0		 5uc1B-1fpqA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		3 / 3 TRP A 148
MET A 149
ASN A 150
 None
 0.90A 5uc1A-1fpqA:
0.7		 5uc1A-1fpqA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		4 / 5 LEU A 321
PHE A 362
PHE A 307
LEU A 325
 None
 1.07A 5x1bP-1fpqA:
1.9		 5x1bP-1fpqA:
19.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		8 / 11 GLY A 217
GLY A 219
ASP A 240
LEU A 241
VAL A 244
ASP A 260
MET A 261
LYS A 274
 SAM  A1699 (-3.6A)
None
SAM  A1699 (-2.9A)
SAM  A1699 (-4.2A)
SAM  A1699 (-4.7A)
SAM  A1699 (-3.8A)
SAM  A1699 (-3.9A)
SAM  A1699 (-4.4A)
 0.66A 6i5zD-1fpqA:
25.0		 6i5zD-1fpqA:
39.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 1fpq ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE
(Medicago
sativa) 		5 / 11 GLY A 218
ASP A 240
LEU A 241
ASP A 260
MET A 261
 None
SAM  A1699 (-2.9A)
SAM  A1699 (-4.2A)
SAM  A1699 (-3.8A)
SAM  A1699 (-3.9A)
 0.95A 6i5zD-1fpqA:
25.0		 6i5zD-1fpqA:
39.44