SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fpr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C
(Homo
sapiens) 		4 / 8 THR A 464
VAL A 467
LEU A 471
ALA A 513
 None
 0.86A 1fiqC-1fprA:
undetectable		 1fiqC-1fprA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C
(Homo
sapiens) 		4 / 8 SER A 455
VAL A 424
GLY A 423
TRP A 419
 None
 0.63A 2qd3A-1fprA:
undetectable		 2qd3A-1fprA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C
(Homo
sapiens) 		3 / 3 ASN A 276
ASN A 305
ARG A 497
 None
 0.86A 2rlcA-1fprA:
undetectable		 2rlcA-1fprA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C
(Homo
sapiens) 		4 / 8 TYR A 511
TYR A 507
ILE A 490
ILE A 468
 None
 0.74A 3p4wC-1fprA:
undetectable		 3p4wC-1fprA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_2
(THYROXINE-BINDING
GLOBULIN)		 1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C
(Homo
sapiens) 		3 / 3 LEU A 265
ARG A 288
ARG A 269
 None
 0.96A 4yiaB-1fprA:
0.0		 4yiaB-1fprA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C
(Homo
sapiens) 		5 / 12 TYR A 366
PHE A 509
ILE A 468
GLY A 430
HIS A 413
 None
 1.12A 5esgA-1fprA:
0.0		 5esgA-1fprA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_A_6ZPA902_1
(GLUTAMATE RECEPTOR 2)		 1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C
(Homo
sapiens) 		4 / 8 PRO A 283
TYR A 303
SER A 455
SER A 287
 None
 1.13A 5l1fA-1fprA:
undetectable
5l1fB-1fprA:
undetectable		 5l1fA-1fprA:
17.66
5l1fB-1fprA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C
(Homo
sapiens) 		4 / 8 TYR A 511
TYR A 507
ILE A 490
ILE A 468
 None
 0.75A 5mzrE-1fprA:
0.0		 5mzrE-1fprA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C
(Homo
sapiens) 		5 / 9 GLN A 440
MET A 472
ASP A 469
ILE A 468
VAL A 431
 None
 1.42A 5v0iA-1fprA:
undetectable		 5v0iA-1fprA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C
(Homo
sapiens) 		5 / 9 GLN A 440
MET A 472
ASP A 469
ILE A 468
VAL A 431
 None
 1.45A 5v0iB-1fprA:
undetectable		 5v0iB-1fprA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_2
(PROTEASE)		 1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C
(Homo
sapiens) 		3 / 3 GLY A 300
ASP A 302
ILE A 304
 None
 0.58A 6dgxB-1fprA:
0.0		 6dgxB-1fprA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1fpr PROTEIN-TYROSINE
PHOSPHATASE 1C
(Homo
sapiens) 		4 / 5 TYR A 376
ARG A 374
THR A 382
LEU A 397
 None
 1.36A 6nknW-1fprA:
0.0		 6nknW-1fprA:
11.87