SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fpt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.13A 1usqA-1fptH:
1.3		 1usqA-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		4 / 6 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.74A 1usqB-1fptH:
1.3		 1usqB-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		4 / 6 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.74A 1usqC-1fptH:
undetectable		 1usqC-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		4 / 6 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.74A 1usqD-1fptH:
1.3		 1usqD-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		4 / 6 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.74A 1usqE-1fptH:
1.2		 1usqE-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.12A 1usqF-1fptH:
undetectable		 1usqF-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		4 / 6 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.81A 2jkjA-1fptH:
undetectable		 2jkjA-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		4 / 6 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.81A 2jkjB-1fptH:
1.3		 2jkjB-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		4 / 6 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.81A 2jkjC-1fptH:
1.3		 2jkjC-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.13A 2jkjE-1fptH:
1.4		 2jkjE-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.13A 2jklA-1fptH:
1.3		 2jklA-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		4 / 6 GLY H  53
PRO H  52
ILE H  51
GLY H  55
 None
 0.80A 2jklB-1fptH:
1.3		 2jklB-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.14A 2jklC-1fptH:
1.3		 2jklC-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.13A 2jklD-1fptH:
1.2		 2jklD-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.13A 2jklE-1fptH:
1.3		 2jklE-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		5 / 7 GLY H  53
PRO H  52
THR H  57
ILE H  51
GLY H  55
 None
 1.13A 2jklF-1fptH:
undetectable		 2jklF-1fptH:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		5 / 12 VAL H 171
VAL H 189
SER H 187
ASN H 209
ASN H 162
 None
 1.42A 3nyaA-1fptH:
undetectable		 3nyaA-1fptH:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		3 / 3 SER H 216
ALA H 211
VAL H 210
 None
 0.62A 4o2bA-1fptH:
undetectable		 4o2bA-1fptH:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		3 / 3 SER H 216
ALA H 211
VAL H 210
 None
 0.61A 4o2bC-1fptH:
undetectable		 4o2bC-1fptH:
18.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5MTH_A_ACTA302_0
(ANTIBODY FAB HEAVY
CHAIN)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		5 / 5 SER H 112
ALA H 114
PHE H 148
LEU H 178
ASP H 181
 None
 0.44A 5mthA-1fptH:
28.6		 5mthA-1fptH:
79.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA CHAIN)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		3 / 3 SER H 216
ALA H 211
VAL H 210
 None
 0.50A 5xiwC-1fptH:
0.0		 5xiwC-1fptH:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)
(Mus
musculus) 		4 / 7 VAL H  20
ILE H  48
GLY H 100
ALA H  93
 None
 0.90A 6hd6B-1fptH:
undetectable		 6hd6B-1fptH:
13.55