SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fpw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1fpw CALCIUM-BINDING
PROTEIN NCS-1
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  68
TYR A 108
PHE A  64
GLY A 188
GLY A  95
 None
 1.01A 1fe2A-1fpwA:
undetectable		 1fe2A-1fpwA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_A_CHCA1001_1
(BILE ACID RECEPTOR)		 1fpw CALCIUM-BINDING
PROTEIN NCS-1
(Saccharomyces
cerevisiae) 		5 / 12 ILE A 164
PHE A 169
ILE A 152
TYR A 186
HIS A  67
 CA  A 502 (-4.0A)
None
None
None
None
 1.37A 1ot7A-1fpwA:
0.0		 1ot7A-1fpwA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 1fpw CALCIUM-BINDING
PROTEIN NCS-1
(Saccharomyces
cerevisiae) 		3 / 3 PRO A  61
MET A 131
TYR A  52
 None
 1.01A 4qa0B-1fpwA:
undetectable		 4qa0B-1fpwA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 1fpw CALCIUM-BINDING
PROTEIN NCS-1
(Saccharomyces
cerevisiae) 		3 / 3 PRO A  61
MET A 131
TYR A  52
 None
 1.01A 4qa0A-1fpwA:
undetectable		 4qa0A-1fpwA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 1fpw CALCIUM-BINDING
PROTEIN NCS-1
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 110
SER A 127
VAL A  71
PHE A  69
 None
 1.04A 4wnvD-1fpwA:
0.0		 4wnvD-1fpwA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 1fpw CALCIUM-BINDING
PROTEIN NCS-1
(Saccharomyces
cerevisiae) 		4 / 6 ILE A  51
TYR A  52
THR A  91
TRP A 103
 None
 1.15A 5g08A-1fpwA:
16.0		 5g08A-1fpwA:
56.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 1fpw CALCIUM-BINDING
PROTEIN NCS-1
(Saccharomyces
cerevisiae) 		4 / 6 TYR A  52
PHE A  55
THR A  91
TRP A 103
 None
 1.28A 5g08A-1fpwA:
16.0		 5g08A-1fpwA:
56.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1fpw CALCIUM-BINDING
PROTEIN NCS-1
(Saccharomyces
cerevisiae) 		5 / 12 MET A 121
ILE A 116
ASP A 187
VAL A 125
ALA A 182
 None
CA  A 501 (-4.6A)
None
None
None
 0.99A 5igiA-1fpwA:
undetectable		 5igiA-1fpwA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1fpw CALCIUM-BINDING
PROTEIN NCS-1
(Saccharomyces
cerevisiae) 		5 / 12 MET A 121
ILE A 116
ASP A 187
VAL A 125
ALA A 182
 None
CA  A 501 (-4.6A)
None
None
None
 0.98A 5igjA-1fpwA:
undetectable		 5igjA-1fpwA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1fpw CALCIUM-BINDING
PROTEIN NCS-1
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 129
VAL A 149
TYR A 186
ILE A 124
 None
 0.84A 5mzrE-1fpwA:
undetectable		 5mzrE-1fpwA:
19.02