SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fq3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1fq3 GRANZYME B
(Homo
sapiens) 		5 / 8 HIS A  57
SER A 190
SER A 195
VAL A 213
GLY A 216
 SO4  A 800 (-4.3A)
None
SO4  A 800 (-2.4A)
None
None
 0.85A 1aq7A-1fq3A:
34.9		 1aq7A-1fq3A:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1fq3 GRANZYME B
(Homo
sapiens) 		4 / 8 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
SO4  A 800 (-2.4A)
None
None
 0.61A 1f5lA-1fq3A:
9.7		 1f5lA-1fq3A:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1fq3 GRANZYME B
(Homo
sapiens) 		4 / 6 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
SO4  A 800 (-2.4A)
None
None
 0.69A 1tnlA-1fq3A:
11.4		 1tnlA-1fq3A:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1fq3 GRANZYME B
(Homo
sapiens) 		4 / 6 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
SO4  A 800 (-2.4A)
None
None
 0.68A 2otvA-1fq3A:
11.6		 2otvA-1fq3A:
36.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1fq3 GRANZYME B
(Homo
sapiens) 		4 / 8 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
SO4  A 800 (-2.4A)
None
None
 0.70A 2vinA-1fq3A:
5.3		 2vinA-1fq3A:
32.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 1fq3 GRANZYME B
(Homo
sapiens) 		4 / 8 VAL A 208
LEU A 181
LYS A 230
GLY A 211
 None
 0.80A 3af0A-1fq3A:
undetectable		 3af0A-1fq3A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_A_SAMA201_0
(YAEB-LIKE PROTEIN
RPA0152)		 1fq3 GRANZYME B
(Homo
sapiens) 		5 / 12 TYR A 215
LEU A 171
ARG A 172
GLY A 216
SER A 214
 None
 1.34A 3okxA-1fq3A:
0.5		 3okxA-1fq3A:
19.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1fq3 GRANZYME B
(Homo
sapiens) 		4 / 6 SER A 190
SER A 195
VAL A 213
GLY A 216
 None
SO4  A 800 (-2.4A)
None
None
 0.73A 3rxfA-1fq3A:
12.6		 3rxfA-1fq3A:
36.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 1fq3 GRANZYME B
(Homo
sapiens) 		4 / 5 ILE A  89
VAL A  52
LEU A  46
ASP A  50
 None
 1.23A 3wzdA-1fq3A:
undetectable		 3wzdA-1fq3A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJQ_A_27RA401_1
(DNA POLYMERASE III
SUBUNIT BETA)		 1fq3 GRANZYME B
(Homo
sapiens) 		4 / 5 ARG A  27
TYR A  29
PRO A 198
VAL A 213
 None
 1.49A 4mjqA-1fq3A:
0.0		 4mjqA-1fq3A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 1fq3 GRANZYME B
(Homo
sapiens) 		5 / 12 VAL A 231
GLY A  44
ILE A 103
LEU A 105
LEU A  46
 None
 1.03A 4qdjA-1fq3A:
undetectable		 4qdjA-1fq3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 1fq3 GRANZYME B
(Homo
sapiens) 		4 / 8 LYS A  86
VAL A  66
GLN A 107
GLU A 109
 None
 1.04A 5dqyA-1fq3A:
0.0		 5dqyA-1fq3A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 1fq3 GRANZYME B
(Homo
sapiens) 		6 / 12 GLY A 142
GLY A  44
GLY A 196
GLY A 193
THR A  54
VAL A  52
 None
None
None
SO4  A 800 (-4.1A)
None
None
 1.34A 5eiwC-1fq3A:
undetectable		 5eiwC-1fq3A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JO9_A_SORA302_0
(RIBITOL
2-DEHYDROGENASE)		 1fq3 GRANZYME B
(Homo
sapiens) 		5 / 12 GLY A 197
PRO A 198
VAL A 138
PHE A  45
LEU A  53
 None
 1.28A 5jo9A-1fq3A:
undetectable		 5jo9A-1fq3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QPA613_1
(SERUM ALBUMIN)		 1fq3 GRANZYME B
(Homo
sapiens) 		4 / 8 ALA A 139
VAL A 138
THR A 189
GLY A 197
 None
 0.98A 5v0vA-1fq3A:
undetectable		 5v0vA-1fq3A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWP_A_FVXA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1fq3 GRANZYME B
(Homo
sapiens) 		5 / 9 ASN A  98
SER A 100
SER A 214
SER A 195
GLY A 196
 None
None
None
SO4  A 800 (-2.4A)
None
 1.39A 6awpA-1fq3A:
undetectable		 6awpA-1fq3A:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 1fq3 GRANZYME B
(Homo
sapiens) 		4 / 7 ALA A  70
GLY A  69
LEU A  68
GLY A 140
 None
 0.82A 6nm4A-1fq3A:
undetectable		 6nm4A-1fq3A:
22.49