SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fr9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_B_017B203_1
(HIV-1 PROTEASE)		 1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
(Escherichia
coli) 		4 / 7 GLU A 129
PRO A 133
ARG A 130
GLY A 128
 None
 1.30A 2hs1B-1fr9A:
undetectable		 2hs1B-1fr9A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R24_A_SAMA302_1
(2'-O-METHYL
TRANSFERASE)		 1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
(Escherichia
coli) 		3 / 3 TYR A  61
ASP A 101
ASP A  24
 None
 0.84A 3r24A-1fr9A:
undetectable		 3r24A-1fr9A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_1
(PROTEASE)		 1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
(Escherichia
coli) 		5 / 9 ALA A  42
VAL A  11
GLY A   9
ILE A   7
ILE A 105
 None
 0.93A 3s43A-1fr9A:
undetectable		 3s43A-1fr9A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S54_B_017B201_1
(PROTEASE)		 1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
(Escherichia
coli) 		6 / 12 ALA A  42
ASP A  41
GLY A   9
ILE A   7
ILE A 135
ILE A 105
 None
 1.49A 3s54A-1fr9A:
undetectable		 3s54A-1fr9A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
(Escherichia
coli) 		6 / 12 PHE A 171
PHE A 178
ALA A 136
THR A 102
VAL A  39
LEU A  43
 None
 1.48A 4j6dA-1fr9A:
0.0		 4j6dA-1fr9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
(Escherichia
coli) 		6 / 12 PHE A 171
PHE A 178
ALA A 136
THR A 102
VAL A  39
LEU A  43
 None
 1.47A 4j6dB-1fr9A:
0.0		 4j6dB-1fr9A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E5J_A_017A201_2
(PROTEASE)		 1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
(Escherichia
coli) 		6 / 12 ALA A  42
ASP A  41
GLY A   9
ILE A   7
ILE A 135
ILE A 105
 None
 1.42A 5e5jB-1fr9A:
undetectable		 5e5jB-1fr9A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8D_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
(Escherichia
coli) 		3 / 3 THR A 134
PRO A  99
ASP A 101
 None
 0.72A 5l8dB-1fr9A:
undetectable		 5l8dB-1fr9A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWU_B_ACTB601_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
(Escherichia
coli) 		3 / 3 THR A 134
PRO A  99
ASP A 101
 None
 0.72A 5mwuB-1fr9A:
undetectable		 5mwuB-1fr9A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8H_B_478B401_2
(PROTEASE)		 1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
(Escherichia
coli) 		5 / 12 ALA A  42
VAL A  11
GLY A   9
ILE A   7
ILE A 105
 None
 0.90A 5t8hB-1fr9A:
undetectable		 5t8hB-1fr9A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
(Escherichia
coli) 		5 / 9 VAL A 169
HIS A 126
ARG A 112
ALA A 110
ASP A 108
 None
 1.11A 6c2mA-1fr9A:
0.0		 6c2mA-1fr9A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
(Escherichia
coli) 		5 / 9 VAL A 169
HIS A 126
ARG A 112
ALA A 110
ASP A 108
 None
 1.13A 6c2mB-1fr9A:
undetectable		 6c2mB-1fr9A:
17.44