SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fs2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_1
(MODIFICATION
METHYLASE RSRI)		 1fs2 SKP2
(Homo
sapiens) 		3 / 3 ASP A 232
HIS A 285
ASP A 280
 None
 0.87A 1nw5A-1fs2A:
undetectable		 1nw5A-1fs2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)		 1fs2 SKP2
(Homo
sapiens) 		4 / 7 SER A 303
ASP A 331
SER A 276
ASN A 301
 None
 1.15A 2cmlA-1fs2A:
undetectable		 2cmlA-1fs2A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 1fs2 SKP2
(Homo
sapiens) 		4 / 8 SER A 276
SER A 250
ASN A 248
GLN A 196
 None
 1.13A 2cmlB-1fs2A:
undetectable		 2cmlB-1fs2A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_B_ZMRB2478_1
(NEURAMINIDASE)		 1fs2 SKP2
(Homo
sapiens) 		4 / 8 SER A 303
ASP A 331
SER A 276
ASN A 301
 None
 1.06A 2cmlB-1fs2A:
undetectable		 2cmlB-1fs2A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_J_BEZJ3352_0
(D-AMINO-ACID OXIDASE)		 1fs2 SKP2
(Homo
sapiens) 		4 / 5 TYR A 358
ILE A 382
ARG A 306
GLY A 304
 None
 1.28A 2du8J-1fs2A:
undetectable		 2du8J-1fs2A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_D_NILD600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1fs2 SKP2
(Homo
sapiens) 		4 / 6 LEU A 263
VAL A 235
LEU A 275
ASP A 280
 None
 0.76A 3cs9D-1fs2A:
undetectable		 3cs9D-1fs2A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1fs2 SKP2
(Homo
sapiens) 		5 / 8 LEU A 247
LEU A 275
ILE A 297
VAL A 293
LEU A 264
 None
 0.94A 3kp6A-1fs2A:
undetectable
3kp6B-1fs2A:
undetectable		 3kp6A-1fs2A:
19.41
3kp6B-1fs2A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 1fs2 SKP2
(Homo
sapiens) 		5 / 10 GLY A 369
GLU A 367
LEU A 377
LEU A 398
ILE A 400
 None
 1.05A 3kvrA-1fs2A:
undetectable		 3kvrA-1fs2A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 1fs2 SKP2
(Homo
sapiens) 		5 / 10 GLY A 369
GLU A 367
LEU A 377
LEU A 398
ILE A 400
 None
 1.06A 3kvrB-1fs2A:
undetectable		 3kvrB-1fs2A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_A_URFA400_1
(URIDINE
PHOSPHORYLASE 1)		 1fs2 SKP2
(Homo
sapiens) 		5 / 9 GLY A 369
GLU A 367
LEU A 377
LEU A 398
ILE A 400
 None
 1.06A 3nbqA-1fs2A:
undetectable		 3nbqA-1fs2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1fs2 SKP2
(Homo
sapiens) 		5 / 11 LEU A 300
LEU A 327
LEU A 302
SER A 332
LEU A 314
 None
 1.16A 3ndvA-1fs2A:
0.0
3ndvB-1fs2A:
undetectable		 3ndvA-1fs2A:
19.74
3ndvB-1fs2A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 1fs2 SKP2
(Homo
sapiens) 		4 / 4 ASN A 236
SER A 224
LEU A 225
THR A 262
 None
 1.36A 4an2A-1fs2A:
undetectable		 4an2A-1fs2A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 1fs2 SKP2
(Homo
sapiens) 		4 / 7 ILE A 361
PRO A 362
GLY A 381
GLN A 378
 None
 0.95A 4g0uB-1fs2A:
undetectable		 4g0uB-1fs2A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1fs2 SKP2
(Homo
sapiens) 		4 / 5 VAL A 235
PHE A 193
CYH A 267
HIS A 292
 None
 1.17A 4rzvA-1fs2A:
undetectable		 4rzvA-1fs2A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 1fs2 SKP2
(Homo
sapiens) 		4 / 8 GLY A 227
CYH A 252
GLY A 251
SER A 276
 None
 0.50A 5vw9A-1fs2A:
undetectable		 5vw9A-1fs2A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1fs2 SKP2
(Homo
sapiens) 		3 / 3 LEU A 260
ASN A 301
LEU A 270
 None
 0.68A 6exiA-1fs2A:
undetectable		 6exiA-1fs2A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1fs2 SKP2
(Homo
sapiens) 		3 / 3 LEU A 317
ASN A 274
LEU A 264
 None
 0.43A 6exiA-1fs2A:
undetectable		 6exiA-1fs2A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 1fs2 SKP2
(Homo
sapiens) 		3 / 3 THR A 262
ALA A 239
LYS A 240
 None
 0.76A 6fgcA-1fs2A:
0.0		 6fgcA-1fs2A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA817_0
(GEPHYRIN)		 1fs2 SKP2
(Homo
sapiens) 		3 / 3 THR A 262
ALA A 239
LYS A 240
 None
 0.76A 6fgdA-1fs2A:
0.3		 6fgdA-1fs2A:
19.59