SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fs5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		5 / 12 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
 None
 1.08A 1fbyA-1fs5A:
undetectable		 1fbyA-1fs5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		5 / 12 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
 None
 1.01A 1fm6A-1fs5A:
undetectable		 1fm6A-1fs5A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_A_NOVA400_2
(DNA GYRASE SUBUNIT B)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		3 / 3 ASN A 147
PHE A 134
VAL A 188
 None
 0.77A 1kijA-1fs5A:
0.0		 1kijA-1fs5A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		3 / 3 THR A   8
LEU A   6
VAL A 238
 None
 0.66A 1mz9E-1fs5A:
undetectable		 1mz9E-1fs5A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		5 / 12 CYH A 239
MET A 237
ALA A 215
THR A 251
LEU A 247
 None
 1.32A 2bjfA-1fs5A:
undetectable		 2bjfA-1fs5A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		4 / 7 ILE A  20
PHE A  63
ILE A  99
PHE A  93
 None
 1.09A 2q6hA-1fs5A:
0.0		 2q6hA-1fs5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QB4_A_DSMA802_1
(TRANSPORTER)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		4 / 7 ILE A  20
PHE A  63
ILE A  99
PHE A  93
 None
 1.09A 2qb4A-1fs5A:
0.0		 2qb4A-1fs5A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		5 / 10 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
 None
 1.03A 3falC-1fs5A:
undetectable		 3falC-1fs5A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_A_486A3_1
(GLUCOCORTICOID
RECEPTOR)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		5 / 12 GLY A 136
VAL A 199
MET A 237
LEU A 212
ILE A 226
 None
 1.40A 3h52A-1fs5A:
undetectable		 3h52A-1fs5A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		5 / 12 ASN A  22
LEU A   6
ALA A  17
MET A  55
GLY A 265
 None
 1.31A 4qckA-1fs5A:
0.0		 4qckA-1fs5A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		5 / 9 THR A  44
ALA A 169
VAL A 203
GLY A 137
ASP A 141
 TLA  A1268 (-3.5A)
None
None
None
None
 1.03A 4qvnK-1fs5A:
undetectable
4qvnL-1fs5A:
undetectable		 4qvnK-1fs5A:
20.86
4qvnL-1fs5A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		5 / 9 THR A  44
ALA A 169
VAL A 203
GLY A 137
ASP A 141
 TLA  A1268 (-3.5A)
None
None
None
None
 1.03A 4qvnY-1fs5A:
undetectable
4qvnZ-1fs5A:
undetectable		 4qvnY-1fs5A:
20.86
4qvnZ-1fs5A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		5 / 10 TRP A  15
LEU A 133
LEU A 229
ALA A 235
GLY A 136
 None
 1.47A 4rn6A-1fs5A:
0.0		 4rn6A-1fs5A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		3 / 3 HIS A  19
ASN A  22
ALA A  26
 None
 0.30A 5n4tB-1fs5A:
undetectable		 5n4tB-1fs5A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_A_9CRA503_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		5 / 12 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
 None
 0.94A 5uanA-1fs5A:
undetectable		 5uanA-1fs5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		5 / 12 ILE A  20
ALA A  17
ALA A  16
LEU A  52
ALA A  51
 None
 1.03A 5z12C-1fs5A:
undetectable		 5z12C-1fs5A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6E8Q_A_X2NA602_0
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE
(Escherichia
coli) 		5 / 12 PHE A  63
ILE A  24
PHE A  93
THR A  48
PHE A 134
 None
 1.19A 6e8qA-1fs5A:
0.0		 6e8qA-1fs5A:
14.90