SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fsk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_D_TC9D1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1fsk ANTIBODY HEAVY CHAIN
FAB
(Mus
musculus) 		4 / 8 THR C  71
TYR C  80
GLN C  82
ILE C  19
 None
 0.98A 2xytE-1fskC:
1.3		 2xytE-1fskC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_G_TC9G1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1fsk ANTIBODY HEAVY CHAIN
FAB
(Mus
musculus) 		4 / 8 THR C  71
TYR C  80
GLN C  82
ILE C  19
 None
 0.81A 2xytH-1fskC:
0.0		 2xytH-1fskC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1fsk ANTIBODY HEAVY CHAIN
FAB
(Mus
musculus) 		4 / 7 THR C  71
TYR C  80
GLN C  82
ILE C  19
 None
 0.83A 2xytI-1fskC:
1.3		 2xytI-1fskC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_A_5FWA601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1fsk ANTIBODY HEAVY CHAIN
FAB
(Mus
musculus) 		5 / 12 VAL C 168
VAL C 186
SER C 184
ASN C 201
ASN C 160
 None
 1.42A 2y03A-1fskC:
undetectable		 2y03A-1fskC:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y03_B_5FWB601_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1fsk ANTIBODY HEAVY CHAIN
FAB
(Mus
musculus) 		5 / 12 VAL C 168
VAL C 186
SER C 184
ASN C 201
ASN C 160
 None
 1.45A 2y03B-1fskC:
undetectable		 2y03B-1fskC:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1fsk ANTIBODY HEAVY CHAIN
FAB
(Mus
musculus) 		5 / 12 GLN C   6
GLN C  82
LEU C  20
THR C 112
LEU C  70
 None
 1.43A 3fsuA-1fskC:
undetectable		 3fsuA-1fskC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 1fsk ANTIBODY HEAVY CHAIN
FAB
(Mus
musculus) 		5 / 11 GLN C   6
GLN C  82
LEU C  20
THR C 112
LEU C  70
 None
 1.40A 3fsuE-1fskC:
0.0		 3fsuE-1fskC:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 1fsk ANTIBODY HEAVY CHAIN
FAB
(Mus
musculus) 		5 / 12 VAL C 168
VAL C 186
SER C 184
ASN C 201
ASN C 160
 None
 1.39A 3nyaA-1fskC:
undetectable		 3nyaA-1fskC:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1fsk ANTIBODY HEAVY CHAIN
FAB
(Mus
musculus) 		4 / 6 THR C  71
TYR C  80
GLN C  82
ILE C  19
 None
 0.88A 3peoG-1fskC:
1.2		 3peoG-1fskC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 1fsk ANTIBODY HEAVY CHAIN
FAB
(Mus
musculus) 		5 / 10 VAL C 168
VAL C 186
SER C 184
ASN C 201
ASN C 160
 None
 1.43A 4ldoA-1fskC:
undetectable		 4ldoA-1fskC:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_2
(CYP51 VARIANT1)		 1fsk ANTIBODY HEAVY CHAIN
FAB
(Mus
musculus) 		3 / 3 PRO C  86
LEU C  11
SER C  17
 None
 0.55A 5fsaB-1fskC:
0.0		 5fsaB-1fskC:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_1
(PROTEIN CYP51)		 1fsk ANTIBODY HEAVY CHAIN
FAB
(Mus
musculus) 		5 / 12 ALA C  16
PHE C 151
TYR C 150
LEU C 113
THR C  87
 None
 1.15A 5tl8A-1fskC:
undetectable		 5tl8A-1fskC:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 1fsk ANTIBODY HEAVY CHAIN
FAB
(Mus
musculus) 		3 / 3 PRO C 189
SER C 190
SER C 191
 None
 0.67A 6bpyA-1fskC:
0.0		 6bpyA-1fskC:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 1fsk ANTIBODY HEAVY CHAIN
FAB
(Mus
musculus) 		5 / 12 VAL C 168
VAL C 186
SER C 184
ASN C 201
ASN C 160
 None
 1.45A 6h7mB-1fskC:
undetectable		 6h7mB-1fskC:
19.29