SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1fta'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 12 LEU A 173
PHE A 193
LEU A 175
ILE A  44
LEU A  30
 None
None
None
None
AMP  A 338 ( 4.2A)
 1.20A 1hrkA-1ftaA:
undetectable		 1hrkA-1ftaA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 12 GLY A 319
GLY A 260
GLY A 259
VAL A 324
ASN A 282
 None
 0.65A 1n2xB-1ftaA:
undetectable		 1n2xB-1ftaA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 11 ARG A 276
GLY A 122
GLU A 280
SER A 124
ASN A 125
 None
 1.30A 1odiA-1ftaA:
0.0		 1odiA-1ftaA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 11 ARG A 276
GLY A 122
GLU A 280
SER A 124
ASN A 125
 None
 1.28A 1odiC-1ftaA:
undetectable		 1odiC-1ftaA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		4 / 7 TYR A 264
TYR A 215
GLY A 273
ASP A 309
 None
 1.09A 2g72B-1ftaA:
undetectable		 2g72B-1ftaA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 12 LEU A 173
PHE A 193
LEU A 175
ILE A  44
LEU A  30
 None
None
None
None
AMP  A 338 ( 4.2A)
 1.21A 2hrcA-1ftaA:
undetectable		 2hrcA-1ftaA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1605_0
(FERROCHELATASE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 12 LEU A 173
PHE A 193
LEU A 175
ILE A  44
LEU A  30
 None
None
None
None
AMP  A 338 ( 4.2A)
 1.21A 2hrcB-1ftaA:
undetectable		 2hrcB-1ftaA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 12 LEU A 173
PHE A 193
LEU A 175
ILE A  44
LEU A  30
 None
None
None
None
AMP  A 338 ( 4.2A)
 1.19A 2po7B-1ftaA:
0.4		 2po7B-1ftaA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_A_BCZA1001_0
(NEURAMINIDASE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 12 ARG A 313
LEU A 275
GLU A 280
GLU A  98
GLU A  97
 None
 1.48A 3k39A-1ftaA:
undetectable		 3k39A-1ftaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_C_BCZC1001_0
(NEURAMINIDASE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 12 ARG A 313
LEU A 275
GLU A 280
GLU A  98
GLU A  97
 None
 1.48A 3k39C-1ftaA:
0.7		 3k39C-1ftaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_E_BCZE1001_0
(NEURAMINIDASE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 12 ARG A 313
LEU A 275
GLU A 280
GLU A  98
GLU A  97
 None
 1.47A 3k39E-1ftaA:
undetectable		 3k39E-1ftaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_G_BCZG1001_0
(NEURAMINIDASE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 12 ARG A 313
LEU A 275
GLU A 280
GLU A  98
GLU A  97
 None
 1.47A 3k39G-1ftaA:
undetectable		 3k39G-1ftaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_H_BCZH1001_0
(NEURAMINIDASE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 12 ARG A 313
LEU A 275
GLU A 280
GLU A  98
GLU A  97
 None
 1.47A 3k39H-1ftaA:
undetectable		 3k39H-1ftaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_K_BCZK1001_0
(NEURAMINIDASE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 12 ARG A 313
LEU A 275
GLU A 280
GLU A  98
GLU A  97
 None
 1.47A 3k39K-1ftaA:
0.8		 3k39K-1ftaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K39_L_BCZL1001_0
(NEURAMINIDASE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 12 ARG A 313
LEU A 275
GLU A 280
GLU A  98
GLU A  97
 None
 1.49A 3k39L-1ftaA:
0.8		 3k39L-1ftaA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 10 VAL A 302
ILE A 316
THR A 255
ILE A 261
VAL A 324
 None
 1.01A 3me6A-1ftaA:
0.0		 3me6A-1ftaA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 12 TYR A 264
ILE A 317
TYR A 215
TYR A 226
ILE A 261
 None
 1.21A 3vrjA-1ftaA:
undetectable
3vrjC-1ftaA:
undetectable		 3vrjA-1ftaA:
22.10
3vrjC-1ftaA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		4 / 7 GLY A 133
ARG A  49
GLY A 168
ALA A 165
 None
 0.77A 5e26A-1ftaA:
undetectable
5e26B-1ftaA:
undetectable		 5e26A-1ftaA:
23.88
5e26B-1ftaA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		4 / 7 ALA A 165
GLY A 133
ARG A  49
GLY A 168
 None
 0.80A 5e26A-1ftaA:
0.0
5e26B-1ftaA:
undetectable		 5e26A-1ftaA:
23.88
5e26B-1ftaA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		4 / 7 GLY A 133
ARG A  49
GLY A 168
ALA A 165
 None
 0.81A 5e26C-1ftaA:
0.0
5e26D-1ftaA:
0.0		 5e26C-1ftaA:
23.88
5e26D-1ftaA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		4 / 8 ALA A 165
GLY A 133
ARG A  49
GLY A 168
 None
 0.80A 5e26C-1ftaA:
undetectable
5e26D-1ftaA:
undetectable		 5e26C-1ftaA:
23.88
5e26D-1ftaA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		4 / 6 GLY A 273
ASP A 251
ILE A 261
TYR A 215
 None
 1.08A 5iwuA-1ftaA:
0.6		 5iwuA-1ftaA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		4 / 5 HIS A 311
ILE A 310
SER A  96
ALA A 152
 None
 1.16A 5msdA-1ftaA:
undetectable		 5msdA-1ftaA:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		3 / 3 ALA A  47
VAL A 132
TYR A 167
 None
 0.72A 5zmqH-1ftaA:
0.0		 5zmqH-1ftaA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYB_A_KKKA508_1
(CYP51, STEROL
14ALPHA-DEMETHYLASE)		 1fta FRUCTOSE-1,6-BISPHOS
PHATASE
(Homo
sapiens) 		5 / 12 TYR A 244
PHE A 327
ALA A 250
LEU A 275
LEU A 318
 None
 1.17A 6aybA-1ftaA:
undetectable		 6aybA-1ftaA:
20.62